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201,169 grants found
Showing 198,421 – 198,440 of 201,169 grants
T cell invasion of the stem cell compartment during immune-mediated GI damage
Despite the importance of intestinal stem cells (ISCs) for epithelial maintenance in the gastrointestinal (GI) tract and the clinical significance of inflammatory intestinal disord...
Extrinsic regulation of primitive, myeloid-biased hematopoietic stem cells by Semaphorin 4a
ABSTRACT Despite substantial experimental evidence for the important functional role of myeloid-biased HSC (myHSC) in stress, inflammation and aging, the mechanisms which control m...
Transcriptional Control of Skeletal Muscle Atrophy
Skeletal muscle atrophy results from insufficient nutrition, aging, certain medications, and a wide range of medical illnesses including cancer, diabetes mellitus, heart or renal f...
Neural Substrates of Binge Drinking
Alcohol misuse is responsible for ~88,000 deaths annually and exerts an annual cost of ~$250 billion in the US.Binge drinking, which accounts for ~75% of these costs, is defined by...
Durability of Epithelial Defects in Crohn's Disease Intestine
PROJECT SUMMARY/ABSTRACT Crohn?s disease is a debilitating and progressive inflammatory disease of the gastrointestinal tract. Defects in epithelial cells are thought to contribute...
Targeting Atg5 in platinum-resistant ovarian cancer
Abstract Ovarian cancer is the fifth leading cause of cancer-related death in the United States.The standard first line chemotherapy to treat this deadly disease includes platinum...
Mechanism of Vascular Impairment in Neurocognitive Disorders
Vascular cognitive impairment and dementia (VCID) is the most common etiology of dementia in the elderly including veterans.Since proportion of the elderly population is progressiv...
Cholangiocyte-Derived Endothelin Signaling Mediates Biliary Injury and Liver Fibrosis
The main goal of this application is to clarify the signaling mechanisms mediating biliary senescence and angiogenesis during primary sclerosing cholangitis (PSC).It is known that...
Toxicant Exposure Impacts Host-pathogen interactions within the Reproductive Tract
Project Summary Exposure to persistent environmental toxicants (such as dioxin) is a global problem, but disproportionately affects Veterans who were exposed dioxin derived from bu...
Machine Learning Models for Identifying Neural Predictors of TMS Treatment Response in MDD
Transcranial magnetic stimulation (TMS) is an effective and easy-to-tolerate treatment for major depressive disorder (MDD). TMS is costly and time-intensive so identifying markers...
Foxp transcription factors in regulatory T cells
Regulatory T cells (Tregs) are critical for actively maintaining immune tolerance.The Foxp family of transcription factors is composed of four members; Foxp1, Foxp3 and Foxp4 are e...
Role of the circadian rhythm on endocannabinoid response to an acute stress
Project Summary Cardiovascular (CV) disease is the leading cause of death in the US.Night and rotating shift work, ~20% of the labor force, is associated with a greater incidence o...
Alterations in Ventral Hippocampal CA1 Processing as a Mechanism for Anxiety in Alzheimer’s Disease
PROJECT SUMMARY/ABSTRACT Anxiety is a highly prevalent and burdensome symptom of Alzheimer disease (AD), especially at early stages, and is linked to faster decline.Further mechani...
Multi Biomarker-based prediction tool development to determine risk of infections-related outcomes among severe blunt trauma patients
Severe trauma injury renders patients vulnerable to infections and subsequent risk of infections-related outcomes, including multiple organ failure/dysfunction syndrome (MOF/MODS),...
Emotion Regulation Flexibility and Suicide Risk
PROJECT SUMMARY/ABSTRACT Suicide is the second leading cause of death for adolescents and young adults, with rates of suicide deaths rising in the past two decades.Research examini...
Unpacking the Multi-level Drivers of Cardiotoxicity Disparities in Breast Cancer Survivors
Abstract The improvement in breast cancer survival is partially due to improvements in treatments. However, these treatments are not without mild to life-threatening side effects.F...
Epigenomic mechanisms regulating RGC survival and axon regeneration
Project Summary/Abstract The proposed study is a five-year career development research plan that focuses on dissecting the epigenetic regulation of retinal ganglion cell (RGC) dege...
Redefining hemophagocytic lymphohistiocytosis in hematologic malignancies
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening inflammatory syndrome that is increasingly recognized in patients with malignancies (M-HLH).However, nearly early eve...
Cerebrospinal fluid derived circulating tumor DNA as a clinically relevant biomarker in medulloblastoma
PROJECT SUMMARY Medulloblastoma (MB) is among the most common malignant brain tumors in children.Despite advances in multi-modal patient care and understanding of tumor biology, on...
Angiogenic biomarker discovery to direct bevacizumab therapy in cervical cancer - Blood-based Angiome Profiling: An ancillary analysis of GOG-0240
Project Summary The anti-angiogenic agent bevacizumab (BEV) is one of the most effective forms of biologic therapy developed thus far for cervical cancer (CC). However, response is...