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201,169 grants found
Showing 198,461 – 198,480 of 201,169 grants
Tuning CAR-T cell function
Abstract Chimeric antigen receptors (CAR) expressed by T cells recognize tumor cells via single chains antibodies and activate T cell cytotoxic machinery and costimulation. In clin...
Physiology-driven seizure management post-cardiac arrest
PROJECT SUMMARY/ABSTRACT Dr. Edilberto Amorim is a neurologist with subspecialty training in critical care and epilepsy who aims to employ biomedical technology innovations in brai...
The investigation of alcohol's effects on threat sensitivity in social context: An event-related potential study.
Abstract Alcohol’s ability to alleviate stress is theorized to represent a core underlying factor in the development of Alcohol Use Disorder (AUD). Of note, researchers conducting...
The isolated impacts of alcohol policies on birth outcomes
Project Summary Identifying policies to reduce fetal exposure to alcohol during pregnancy is a high public health priority. More than 85% of US states have pregnancy-specific alcoh...
Visualizing and elucidating the FGF-dependent mechanisms of urethral morphogenesis
PROJECT SUMMARY Hypospadias is a birth defect wherein the urethral opening is displaced from the distal end of the penis and instead terminates on the ventral side of the penis, or...
Effects of Acute Exercise on Functional Magnetic Resonance Spectroscopy Measures of GABA in Aging and Chronic Stroke
The current proposal seeks to index the effect of acute aerobic exercise on excitatory and inhibitory balance using magnetic resonance spectroscopy (MRS) in aging and in chronic st...
Mechanisms of Metabolicand GLP-1 receptor signaling on Islet hormone secretion
Project Summary Diabetes is a prominent disease that affects people worldwide and is rapidly becoming more prevalent; it is estimated that 640 million people will be diagnosed with...
Molecular mechanisms of exocytotic vesicle fusion and release.
Fusion of membrane bound vesicles with a target membrane is of ubiquitous importance for cellular function from intracellular trafficking to exocytotic release of various mediators...
Cognate effects in bilingual adults with and without a history of Developmental Language Disorder
Project Summary/Abstract Poor vocabulary is linked to lower educational and vocational attainment. Adults with a history of Developmental Language Disorder (DLD) have reduced vocab...
Astrocyte Calcium Signaling in Neuropathic Pain
PROJECT SUMMARY Chronic pain is a hallmark of many disease conditions, including nerve and spinal cord injury. Current mainstays of pain management include analgesics and anestheti...
Neuromodulation of long-term sequelae of ischemic acute kidney injury
Project Summary Acute kidney injury (AKI) is recognized as a major risk for progressive chronic kidney disease (CKD).However, the mechanism by which AKI leads to fibrogenesis and u...
Identifying Fundamental Mechanisms that Mediate Resistance to Anti-Cancer Therapies
A major obstacle to achieving long-term cancer remission is the ability of some cancer cells to resist therapy.Strikingly, the fundamental cell biology underlying therapy resistanc...
Mechanisms driving the development of threat sensitivity following early life adversity
Project Summary Exposure to early life adversity (ELA) confers significant risk for psychiatric disorders that are often unresponsive to traditional treatments.Importantly, most EL...
Silencing the uroguanylin-GUCY2C gut-brain axis mediates leptin resistance in obesity
PROJECT SUMMARY/ABSTRACT Obesity is a global pandemic with accelerating trends in morbidity, mortality, and medical expenditures. Treatments have been limited in efficacy or burden...
Mentored Education for Dissemination and Implementation Science IS2 Program
Abstract This is an application for an administrative supplement to increase the number of diabetes investigators who can receive mentored training in dissemination and implementat...
MYCOBACTERIUM TUBERCULOSIS (MTB) QUALITY ASSESSMENT PROGRAM (TBQA)
The purpose of the Mycobacterium Tuberculosis (Mtb) Quality Assessment Program (TBQA) is to provide a new resource to assess the ability of laboratories located both in the United...
SUPPORT THE ONGOING OPERATIONS OF THE NATIONAL DATABASE FOR AUTISM RESEARCH - NDAR
The NIH is interested in advancing research to identify common genetic or other factors that influence the prevention, cause, diagnosis, and treatment of autism spectrum disorders....
Mechanisms and evolutionary consequences of transposon strategies to counteract host silencing
PROJECT SUMMARY Harboring active transposable elements (TEs) imposes a substantial mutational burden on the host genome.To reduce this burden, most organisms have evolved sophistic...
4/4: Improving the Part C Early Intervention Service Delivery System for Children with ASD: A Randomized Clinical Trial
PROJECT SUMMARY Despite strong consensus that early, specialized intervention for children with Autism Spectrum Disorder (ASD) can have a dramatic impact on outcomes, the U.S. heal...
Characterizing human-specific expression of ZP2 in the cerebellum
SUMMARY Finding new treatments for neuropsychiatric disorders is a priority, as these disorders affect over 1 in 5 US adults and cost the US health care system over 180 billion dol...