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201,169 grants found
Showing 198,481 – 198,500 of 201,169 grants
Characterization of Alternative Polyadenylation in Alzheimer's Disease
Abstract Alzheimer's disease (AD) is a slowly progressive brain disorder characterized by cognitive decline, irreversible memory loss, disorientation, and language impairment....
Mechanistic analysis and allellic genome editing of iPSC-derived dominant LCA model
PROJECT SUMMARY Leber congenital amaurosis (LCA) is a group of devastating early-onset retinal dystrophies affecting roughly 1/50,000 to 1/33,000 newborns.LCA-associated variants i...
Synergistic Material-Microbe Interface towards Faster, Deeper, and Air-tolerant Reductive Dehalogenation
Project Summary/Abstract Challenges exist in bioremediation of halogenated contaminants, including low donor utilization efficiency and slow dehalogenation, low dehalogenation acti...
Supplemental request for MAX-TL Ultracentrifuge and rotor
SUMMARY/ABSTRACT (for R35 GM139550) Our research program combines detailed biochemical reconstitution experiments with powerful cell-based assays, with a goal of gaining fundamenta...
New Statistical Methods for Modelling Cancer Outcomes
PROJECT SUMMARY/ABSTRACT Lung cancer is one of the most common causes of mortality worldwide. Radiomic features have been shown to provide prognostic values in predicting lung canc...
Re-engineered Mitochondrially Targeted p53 Gene Therapy in Liver Cancer
Abstract: Hepatocellular carcinoma (HCC), the most common cancer of the liver, is the third leading cause of cancer death worldwide. In the U.S., the overall 5-year survival rate f...
Receptor-mediated glucose sensing and skeletal muscle function
PROJECT SUMMARY Skeletal muscle is central to the development of metabolic dysfunction during type 2 diabetes (T2D) and obesity. In addition, these conditions are often accompanied...
UNDERSTANDING THE MECHANISMS OF UNDERLYING R-LOOP BIOGENESIS AND RESOLUTION IN MAMMALS
Project summary During transcription, the nascent RNA can anneal with the template DNA strand behind the advancing RNA polymerase and cause the formation of alternative DNA structu...
Ultraviolet Photodissociation Mass Spectrometry for Characterization of Biological Molecules
Abstract.Understanding the functions of lipids, proteins and even larger macromolecular assemblies depends on deciphering complex structures of individual molecules as well as decr...
TAK1 signaling pathways
Abstract Innate immune signaling pathways are activated in response to exposure to microorganisms, and generally are effective in preventing pathogen invasion through inducing infl...
Epigenomic mechanisms regulating RGC survival and axon regeneration
Project Summary/Abstract The proposed study is a five-year career development research plan that focuses on dissecting the epigenetic regulation of retinal ganglion cell (RGC) dege...
Tulane StARR Program
Program Summary This is a new application for the Tulane StARR Program with a long-term goal to increase the number and diversity of highly trained, independent, interdisciplinary...
Enterotoxigenic Bacteroides fragilis in modulation of host immunity
PROJECT SUMMARY Humans and other mammals are colonized by a plethora of microorganisms at the time of birth. The constellation of microorganisms that inhabit the gut is key in the...
Regulating transcription of the key neural lineage driver ASCL1 - Diversity Administrative Supplement
The bHLH transcription factor ASCL1 (HASH1/MASH1) is essential for neuronal differentiation and sub-type specification of multiple neuronal cell-types throughout the brain, spinal...
AI/ML Ready appraoches for integrative RNA processing, splicing and spatial genomics
Project Summary/Abstract From parent grant: Cells and organisms, from simple to complex, carry the same genetic DNA sequence organized into genes. Multicellular eukaryotes transcri...
Alzheimer's Disease: New Trial Designs for Emerging Challenges
Project Summary/Abstract Alzheimer?s disease (AD) is characterized by heterogeneity in sex, race, APOE ?4 status, and tau. APOE ?4 status has been used to stratify AD patients in c...
Supplement to: Transcription control of retinal neuron specification and maturation
PROJECT SUMMARY/ABSTRACT Amacrine cells (ACs) are the principle inhibitory neurons of the inner retina, with at least 45 morphologically distinct subtypes that can be distinguished...
Dynamics, Regulation and Function of p53 in Single Cells
The dynamics of signaling systems are critical for controlling gene expression programs and cellular outcomes.The tumor suppressor protein p53 is a transcription factor orchestrati...
Nanochelation Therapies for Iron Overload Disorders
PROJECT SUMMARY/ABSTRACT Iron overload, best represented by hereditary hemochromatosis (primary/genetic iron overload) and transfusional hemoglobinopathy (secondary/acquired iron o...
Network-based algorithms for target identification and drug repositioning from genetic associations
In the field of genetics, genome-wide association studies of common variants (GWAS) and exome sequencing- based analyses are a common strategy to elucidate the relationship between...