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201,169 grants found
Showing 198,501 – 198,520 of 201,169 grants
The functions of the zinc finger protein ZPR1 in R-loop metabolism and neurodegeneration.
PROJECT SUMMARY The goal of this study is to examine the functions of the zinc finger protein ZPR1 in R-loops metabolism and neurodegeneration. R-loops are formed during transcript...
How do CNS fibroblasts regulate the response to neuroinflammation?
ABSTRACT Fibrosis, defined by the deposition of collagen I, is a devastating pathological event that occurs in many organs including the heart, kidney, liver and lung in response t...
Efficacy of Fenofibrate for COVID-19: A phase II randomized controlled trial
PROJECT SUMMARY Aging, obesity, diabetes, hypertension and other risk factors associated with abnormal lipid and carbohydrate metabolism are risk factors for death in Coronavirus d...
Accelerating Translational Development of Novel Antigens for an Enterotoxigenic E. coli Vaccine
Project Summary/Abstract This proposal addresses the need to improve candidate vaccines for enterotoxigenic Escherichia coli (ETEC), one of the commonest causes of severe bacterial...
TAMU TISSUE CHIP CONSORTIUM (TCC) MEMBERSHIP FEE
Human-relevant complex in vitro modeling systems, often referred to as ?tissue chips? are a rapidly developing area of technology that offer great promise for advancing the ability...
Molecular mechanisms of exocytotic vesicle fusion and release.
Fusion of membrane bound vesicles with a target membrane is of ubiquitous importance for cellular function from intracellular trafficking to exocytotic release of various mediators...
X-ray/optical tomographic guidance and assessment for pre-clinical radiation Research
PROJECT SUMMARY/ABSTRACT Over the past 10-years, our group has made multi-disciplinary efforts to bridge the technological gap between radiation methods for human treatment and pre...
The Effects of Early Psychosocial Deprivation on Cardiometabolic Risk in Early Adulthood
Project Summary/Abstract The Bucharest Early Intervention Project (BEIP)—the only randomized controlled trial (RCT) comparing foster care to institutional care for young children—w...
Molecular mechanisms underlying neuronal integrity
ABSTRACT Neurons have an astonishing ability to maintain their integrity throughout an organism’s lifespan. Both the functional and structural integrity are required for neurons to...
CD28 Regulation of Alternative Splicing Changes in Human T cells
Project Summary Alternative splicing consists of exons that are selectively included or excluded from the mature mRNA transcript. In fact, most protein encoding genes, approximatel...
The Impact of Negative Familial Weight Talk on Weight Bias Internalization and Preliminary Efficacy of Intervention in Early Adolescents
PROJECT SUMMARY Weight stigma undermines the health and quality of life of early adolescents. Negative familial weight talk, which refers to weight teasing and critical comments ab...
Regulation of Monocyte Entry to the Brain During Neuroinflammation
Project Summary Neuroinflammation can have both protective and detrimental outcomes in brain health, depending on the context. Immune cells that traffic to the brain may be critica...
Engineering Brain Cancer in a Dish: Hydrogel-based 3D in vitro Models for Pediatric Brain Tumor
Diffuse intrinsic pontine gliomas (DIPG) are a highly aggressive pediatric brain tumor of the ventral pons (brain stem), with a five-year survival rate of less than 1% and a median...
Multifaceted Home Environment Interacting with Brain Networks Beyond Socioeconomic Circumstances
PROJECT SUMMARY Household socioeconomic status (SES) is a major contributor to child brain and cognitive growth, and related to their future educational and occupational outcomes....
Development of a Tailored Intervention to Increase Veteran Enrollment in Cardiac Rehabilitation
Background: This Veterans Affairs (VA) Health Services Research & Development Career Development Award resubmission is a five-year plan that will enable the candidate, a staff...
Pharmacological Npt2a inhibition as a treatment for hyperphosphatemia in chronic kidney disease
The precise regulation of the body's phosphate homeostasis is a critical task. Treatment of hyperphosphatemia, which becomes inevitable in later stages of chronic kidney disea...
Molecular mechanisms of Gram-negative outer membrane organization
The rising frequency of drug-resistant bacterial infections pose an imminent threat to human health. Attempts to generate novel antibiotics to address this problem often fail becau...
The Striatum and Hippocampus: "Hubs" of White Matter Connections in Parkinson's Disease Cognitive Decline
Due to an aging population and increased lifespan, dementia is an increasing clinical and public health issue.The most common and well-known cause is Alzheimer’s disease (AD), but...
Structure and Function of Primate Retinal Circuits
An understanding of the normal structure and function of the retina is important to appreciate changes that occur during disease, development and aging. To this end, a longstanding...
Regulation of the neuroinflammatory response in autoimmune uveitis
Research Abstract: Autoimmune uveitis is a serious sight-threatening condition defined by an autoreactive immune response against the retina and uveal tissues. In autoimmune uveiti...