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201,169 grants found
Showing 198,521 – 198,540 of 201,169 grants
Evolution of Cargo Transport
Transporting cellular cargo with spatial and temporal precision is critical for many processes in all cells. Different cell types and organisms use diverse machineries for long-dis...
Mitochondrial pyruvate transport in retinal health and disease
PROJECT SUMMARY/ABSTRACT The retina is the most metabolically active neuronal tissue in the human body. The defect in the energy metabolism of photoreceptor neurons and their suppo...
Targeting polyamines to suppress SARS-CoV-2 related disease
ABSTRACT The pandemic COronaVIrus disease 2019 (COVID-19) is an infectious disease, which is caused by a novel and highly pathogenic virus strain SARS-CoV-2 (Severe acute respirato...
Superresolution Light Sheet Microscopy for imaging model organisms with 200nm resolution
Project Summary Light Sheet Microscopy has become an essential tool for investigating a wide variety of biological problems from developmental questions to mapping neural circuits....
SCH: Advancing Language-based Analyses of Social Media to Reliably Monitor Variation in Population
This proposal seeks to address a key challenge in public health : the ongoing and fine-grained measurement of population mental health. Currently, in the largest population surveys...
Molecular mechanisms of excitatory postsynaptic diversity
Unique patterns of synaptic connectivity between neurons, and the differential strength of those synapses, are fundamental to the information processing capability of the brain. Sy...
Red Blood Cells shuttle beta amyloid between brain and heart: implications for the pathogenesis and the progression of Alzheimer's and Cardiomyopathy
Abstract Alzheimer disease (AD) is the most frequent form of dementia causing a significant reduction of quality of life of affected patients. In the brains of AD patients, β-amylo...
High Resolution Mapping of Foveal Ganglion Cell Receptive Fields in the Living Primate Eye
The importance for vision of the tiny fovea has been established by centuries of investigation as well as observations of the devastating consequences of its damage through injury...
Exploiting convergent evolution to design biomarker extraction tools for the prediction of therapeutic response in cancer
PROJECT SUMMARY/ABSTRACT The effective treatment of drug resistant tumors represents one of the greatest unmet needs in oncology research. The evolution of therapeutic resistance i...
Community Action to Promote Healthy Environments
PROJECT SUMMARY The overarching goals of the Community Action to Promote Healthy Environments (CAPHE) partnership, established in 2014, are to: (1) develop new knowledge on local c...
Dissociable neural mechanisms of reactive versus appetitive aggression
Project Summary Maladaptive aggression characterizes - or is comorbid with - many neuropsychiatric illnesses, and can have devastating effects on individuals, their caretakers, and...
Mechanisms of Sex Determination in Zebrafish
The Problem: Differences in (or Disorders of) Sex Development (DSD) are complex medical issues that involve multiple interacting cell types and organ systems. DSDs impact disease s...
Regulatory mechanisms of the Hsp90 chaperone machinery
PROJECT SUMMARY The molecular chaperone Heat Shock Protein-90 (Hsp90) is essential for the folding and activity of an array of `client' proteins involved in signal transductio...
Identification of genetic and environmental suppressors of mitochondrial dysfunction
Project Summary Mitochondrial diseases, or inherited disorders of oxidative phosphorylation, can be caused by mutations in at least 290 genes and affect approximately 1 in 5,000 li...
A Leukemia Cell-Specific Coiled-Coil Protein for Treatment of Chronic Myeloid Leukemia
Project Summary/Abstract The long-term goals of this proposal are to explore the protein dimerization interface as an area for therapeutic intervention. Protein dimerization/oligom...
Mitochondrial-targeted antioxidant supplementation for improving age-related vascular dysfunction in humans
Project Summary The vast majority of cardiovascular diseases (CVD) occur in men and women ≥60-years of age. Changes in the demographics of aging in the U.S. predict progressive inc...
Neurally targeted group intervention to reduce early childhood anxiety
Clinically significant anxiety affects 20% of preschoolers and can become chronic, leading to depression, substance abuse, school-drop out and even suicide. To reduce anxiety and p...
Genetic and molecular correlates of white matter pathology in Alzheimers disease
PROJECT SUMMARY: Although Alzheimer's disease (AD) is typically defined by the accumulation of beta- amyloid and hyperphosphorylated tau proteins, synaptic loss and neuronal d...
MICROBIOTA-DEPENDENT CONTROL OF CLOSTRIDIUM DIFFICILE: THE ROLE OF ACETATE AND IL-22 BINDING PROTEIN
PROJECT SUMMARY The overall goal of this application is to establish avenues through which we can harness the intestinal microbiota to enhance mucosal immune responses against Clos...
Using Genetic Diversity to Manage Neurological Disease
Project Summary/Abstract Understanding and treating genome abnormalities that lead to rare genetic neurodegenerative diseases such as Niemann-Pick C1 globally managing cholesterol...