Browse All Grants
201,169 grants found
Showing 198,581 – 198,600 of 201,169 grants
Diagnosing and predicting risk in children with SARS-CoV-2- related illness
In the wake of COVID-19 pandemic, Multisystem Inflammatory Syndrome in Children (MIS-C) has evolved as a new threat to children exposed to SARS-CoV-2. The emergence of MIS-C is so...
Optimizing SARS-CoV-2 wastewater based surveillance in urban and university campus settings.
The novel coronavirus SARS-CoV-2 is causing significant morbidity and mortality. Current approaches to SARS- CoV-2 testing are costly, inconsistently implemented, and fail to rapid...
Improved scalability, sensitivity, and interpretability of pathogen detection, including SARS-CoV-2, in wastewater using high-throughput, highly multiplexed digital array PCR technology
PROJECT ABSTRACT Presently, the application of molecular technology such as RT-qPCR and digital PCR (dPCR) to quantify SARS-CoV-2 and related targets in wastewater is cumbersome, t...
COVID-19 Network of Networks Expanding Clinical and Translational approaches to Predict Severe Illness in Children (CONNECT to Predict SIck Children)
The SARS-CoV-2 pandemic has manifested in children with a wide spectrum of clinical presentations ranging from asymptomatic infection to devastating acute respiratory symptoms, app...
Wastewater Analysis of SARS CoV-2 in Tribal Communities
ABSTRACT The rapid onset of the COVID-19 pandemic left many across the world unprepared to test, treat, and plan for coronavirus morbidity and mortality. This was true for Tribal n...
Wastewater Assessment for Coronavirus in Kentucky: Implementing Enhanced Surveillance Technology
Wastewater Assessment for Coronavirus in Kentucky – Implementing Enhanced Surveillance Technology Surveillance for SARS-CoV-2 is hindered by the availability of testing, particular...
A data science approach to identify and manage Multisystem Inflammatory Syndrome in Children (MIS-C) associated with SARS-CoV-2 infection and Kawasaki disease in pediatric patients
Summary – Since the SARS-CoV-2 pandemic began, the emergence of an associated novel multisystem inflammatory syndrome in children (MIS-C) has been reported. Interestingly, patients...
Development and Proof-of-Concept Implementation of the South Florida Miami RADx-rad SARS-CoV-2 Wastewater-Based Surveillance Infrastructure
PROJECT SUMMARY The University of Miami (UM), with three primary campuses in Miami, Florida, is geographically spread within one of the worst current COVID-19 hotbeds. UM has deplo...
Dissecting the mechanistic role of multinucleation in breast and trophoblast cancers
Project Summary/Abstract A key driver of cancer is the global deregulation of transcription networks in the cell. Transcriptional output is dependent on chromatin structure and top...
The pursuit of genetic causal mechanisms
Project Summary Recent years have witnessed the development of large research projects that involve genotyping hundreds of thousands of individuals, on which we have available deta...
Discovery and clinical validation of host biomarkers of disease severity and multi-system inflammatory syndrome in children (MIS-C) with Covid-19
ABSTRACT Novel approaches for early and accurate diagnosis of COVID-19 associated syndromes and evaluation of clinical severity and outcomes of COVID-19 disease in children are urg...
Synaptic Architecture and Mechanisms of Direction Selectivity in Primate Retina
A major research challenge for neurobiology is to understand the neural mechanisms that give rise to an extreme diversity of parallel visual pathways and ultimately the contributio...
Early Detection and Diagnosis of Lung Cancer with Endomicroscopy
PROJECT SUMMARY Early diagnosis of lung cancer is critical to patient survival. Unfortunately the vast majority of cases are detected once symptoms arise and the cancer has spread...
The role of type 1 dendritic cells in CD4 and CD8 T cell anti-tumor immunity
PROJECT SUMMARY Cancer immunotherapies have revolutionized the treatment of malignancies, but these therapeutics still face enormous challenges and limited efficacy in many patient...
Modeling Immune Cell Recruitment and its Impact on Triple Negative Breast Cancer Recurrence in the Irradiated Microenvironment
PROJECT SUMMARY Approximately half of triple negative breast cancer (TNBC) patients receive breast conserving therapy, which includes irradiating the primary tumor site. Although t...
Mycobacterial Lung Diseases in Virginia: sequencing and clinical determinants of relapse and outcome
PROJECT SUMMARY / ABSTRACT Nontuberculous mycobacterial lung diseases, primarily due to M. avium complex (MAC), is an increasing clinical problem nationwide and now overtakes domes...
Epigenetic dysregulation in diabetic enteric neuropathy
Diabetic gastroenteropathy includes asymptomatic delayed gastric emptying, dyspepsia with or without mildly delayed gastric emptying, or gastroparesis, which is characterized by mo...
Novel Statistical Methods for Multi-omics Data Integration in Alzheimer's Disease
Novel Statistical Methods for Multi-omics Data Integration in Alzheimer's Disease Principal Investigators: Chong Wu, Ph.D. (contact); Jonathan Bradley, Ph.D. Summary A fundame...
Enabling Technology to Screen and Quantify Sialylated Structures for Activity Against Viral Enzymes and Receptors
Sialylated glycans are involved in complex regulation and signaling and play a critical role in disease. In the virus life cycle, receptor binding and sialic acid cleavage to facil...
Understanding and targeting bone marrow microenvironment in myelofibrosis
Project summary/Abstract Understanding and targeting abnormal tumor microenvironment is critically important for developing effective therapy. Primary myelofibrosis (PMF) is a form...