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201,169 grants found
Showing 198,601 – 198,620 of 201,169 grants
How do CNS fibroblasts regulate the response to neuroinflammation?
ABSTRACT Fibrosis, defined by the deposition of collagen I, is a devastating pathological event that occurs in many organs including the heart, kidney, liver and lung in response t...
Mechanisms and evolutionary consequences of transposon strategies to counteract host silencing
PROJECT SUMMARY Harboring active transposable elements (TEs) imposes a substantial mutational burden on the host genome. To reduce this burden, most organisms have evolved sophisti...
Impact of brain estrogens on cognition and brain aging in a non-human primate
SUMMARY Aromatase inhibitors (AIs) are drugs that inhibit estrogen synthesis and that are prescribed to prevent the recurrence of estrogen responsive breast cancers. However, AIs,...
Chronic Lung Disease and COVID-19: Understanding Severity, Recovery and Rehabilitation Needs (LAUREL Study)
SARS-CoV-2 (SARS2) infection, which leads to COVID-19, is a global pandemic. Chronic lung disease (CLD), particularly chronic obstructive pulmonary disease (COPD), has emerged as a...
Surfactant Protein C Mouse Models: A Fit For Purpose Preclinical Platform For Advancing Discovery In And Treatment Of Idiopathic Pulmonary Fibrosis
ABSTRACT Idiopathic Pulmonary fibrosis (IPF) is a devastating interstitial lung disease (ILD) of older adults characterized by disruption of distal lung architecture that ultimatel...
Understanding the mechanisms underlying R-loop biogenesis and resolution in mammals
Project summary During transcription, the nascent RNA can anneal with the template DNA strand behind the advancing RNA polymerase and cause the formation of alternative DNA structu...
Telomerase-Mediated Healing of Double-Strand Breaks in Human Cells
PROJECT SUMMARY/ABSTRACT Telomeres—which define and protect the ends of humans’ linear chromosomes—serve as a natural check on carcinogenesis. Genome stability requires cells to di...
Heterochromatin as a barrier to regeneration in the mouse cochlea
PROJECT SUMMARY/ABSTRACT The main cause of hearing loss is damage of cochlear sensory hair cells within the inner ear. The long-term objective of the Segil lab is to treat human de...
Novel population-genetic methods for localizing targets of natural selection in diverse human genomes
PROJECT SUMMARY. The PI's research program in population genetics focuses on the coalescent-based inference of population his- tories from whole genomes, and the determination...
Mechanisms of RNA polymerase II transcription regulation
SUMMARY/ABSTRACT Our research program combines detailed biochemical reconstitution experiments with powerful cell-based assays, with a goal of gaining fundamental mechanistic insig...
Infection Control Measures in Dialysis Facilities after COVID-19: Disparities in Adoption and Impact on Hospitalization and Mortality
PROJECT SUMMARY The COVID-19 pandemic threatens the health of patients with kidney failure because end-stage kidney disease (ESKD) is a risk factor for COVID-19 related death. Most...
Novel small molecule USP7 Inhibitors for p53 activation and cancer therapy
Project Summary: The long-term objective of this project is to develop a novel targeted therapy for human cancers by reactivating the tumor suppression pathways. Although p53 is fr...
cryoEM Studies of Muscle
Project Summary The long term goal of this research project has been and continues to be an understanding of the molecular mechanism of muscle function. The existing project, funde...
Improving CDK 4/6 inhibition in the treatment of medulloblastoma
PROPOSAL ABSTRACT This proposal will develop CDK4/6 inhibitor therapy for medulloblastoma, using a novel, nanoparticle formulation of palbociclib, studied in vivo in transgenic med...
Discovery of myeloid immune features predictive of response to cancer immunotherapy in prostate cancer
PROJECT SUMMARY/ABSTRACT Cancer immunotherapy has been a revolutionary antitumor treatment and is approved to treat a plethora of cancer types. However, in solid tumors the respons...
Investigating the Associations Between Safety Cue Learning and Trauma Exposure in Development
Exposure to trauma throughout the lifespan, and in particular during childhood and adolescence, is prevalent, with more than two-thirds of all children in the United States having...
Development of Blood Delivery Networks for Silicon Nanomembrane-Enabled Low-Volume Membrane Oxygenators
Abstract The overall goal of this project is to optimize performance and hemocompatibility of prototype blood oxygenators enabled by silicon nanomembranes. To achieve this, the pro...
Examining the role of the neighborhood environment on muscle function in older adults
PROJECT SUMMARY/ABSTRACT Poor muscle function is a pressing public health problem: half of all U.S. older adults meet criteria for muscle weakness. Poor muscle function, defined by...
Learning principles from the pyrenoid, a phase-separated organelle
PROJECT ABSTRACT Phase separation is an emerging organizing principle for intracellular biology. Processes that are now understood to exploit phase separation include storage of ge...
Development of Asymmetric Cooperative Gold Catalysis and Beyond
Cooperative catalysis or catalysis involving metal-ligand cooperation is a highly versatile approach in catalysis that have resulted in a myriad of highly efficient synthetic metho...