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201,169 grants found
Showing 198,621 – 198,640 of 201,169 grants
Multiethnic genomic epigenomic and transcriptomic fine-mapping and functional validation analysis of schizophrenia and bipolar disorder risk loci
PROJECT SUMMARY Serious mental illness (SMI) that includes schizophrenia (SCZ) and bipolar disorder (BD) are common, complex and debilitating psychiatric disorders that together af...
Mechanisms of Advanced NAFLD Disparities in Hispanics: A Multi-level Analysis
PROJECT SUMMARY/ABSTRACT Nonalcoholic fatty liver disease (NAFLD) leading to nonalcoholic steatohepatitis (NASH) is a major cause of chronic liver disease that may progress to cirr...
Base editing and prime editing for sickle cell disease
PROJECT SUMMARY Despite advances in the medical care of sickle cell disease (SCD), most patients continue to experience severe pain, poor quality of life, progressive organ deterio...
Cerebrospinal fluid derived circulating tumor DNA as a clinically relevant biomarker in medulloblastoma
PROJECT SUMMARY Medulloblastoma (MB) is among the most common malignant brain tumors in children. Despite advances in multi-modal patient care and understanding of tumor biology, o...
A Novel Broad-spectrum Antiviral Agent
Summary Accelerating emergence and re-emergence of a wide array of viral epidemics has been a deadly feature of the 21st century. Potent or even effective therapies are rarely avai...
Identifying Protein-Protein Network Interactions between COPD Susceptibility Genes
PROJECT SUMMARY Genome-wide association studies (GWAS) of complex diseases like COPD have identified many genomic regions associated with disease, but the molecular mechanisms by w...
Investigating gene regulatory networks in immune cells of children who differ in susceptibility to malaria infection using single-cell approaches
Project Summary/Abstract Malaria kills over 400,000 people annually, underscoring the need for a highly effective malaria vaccine. A better understanding of immunity to Plasmodium...
The Alabama Cardiovascular Cooperative: Supporting Cardiovascular Risk Reduction in Primary Care
In the United States (U.S.), the last three decades have seen vast improvements in cardiovascular disease (CVD) risk and mortality, however, these gains are not consistent across a...
Responses of the Program of All-Inclusive Care of the Elderly (PACE) Organizations to COVID-19 Challenges: Effects and Lessons Learned
Project Summary/Abstract. PACE (the Program of All-Inclusive Care for the Elderly) is a well-known and respected financing and care delivery model for a very challenging population...
Healthy Hearts for Michigan (HH4M): Providing support to improve the heart health and help reduce CVD disparities by engagement with primary care practices.
Project Abstract. Heart attack and stroke are two of the leading causes of death in the United States, accounting for approximately 800,000 deaths, and over $300 billion in healthc...
Translating research into school-based practice via small-group, language-focused comprehension intervention
PROJECT SUMMARY The long-term goal of this research is to translate years of federally-funded basic science on comprehension processes and interventions to provide elementary-age c...
Action of Lipolytic Enzymes
PROJECT SUMMARY/ABSTRACT The overall goal of this grant in recent years has been to describe in molecular detail the mechanism of action of physiologically important human forms of...
Role of mitophagy in age-related respiratory and vascular diseases
PROJECT SUMMARY/ABSTRACT The overarching theme of my research program is to understand how innate immunity enhances age- associated cardiovascular and pulmonary diseases. As a phys...
Phase 2 Study of Theophylline for the Treatment of Psuedohypoparathyroidism
Pseudohypoparathyroidism (PHP) is a rare, genetic disorder caused by impaired stimulatory G protein (Gsα) signaling through downregulation of the gene, GNAS.The resultant hormone a...
Alzheimer's Disease: New Trial Designs for Emerging Challenges
Project Summary/Abstract Alzheimer’s disease (AD) is characterized by heterogeneity in sex, race, APOE ε4 status, and tau. APOE ε4 status has been used to stratify AD patients in c...
Light regulated vascular development in the eye via the Hippo pathway
Light regulated vascular development in the eye via the Hippo pathway Our recent studies show that opsin-mediated light responses function as developmental timing cues for vascular...
Acoustically-driven optical-interferometric microscope for cell characterization
AbstractThe goal of this proposal to develop a first of its kind acoustically driven quantitative phase microscopy (QPM) rheology system. Mechanical forces play an important role i...
RNA Nanosystem for Posterior Eye Drug Delivery
RNA nanotechnology provides molecules that have the simplicity in design with the characteristics of DNA and can be used in therapies. However, a major problem in RNA nanotechnolog...
Emotion Regulation Flexibility and Suicide Risk
PROJECT SUMMARY/ABSTRACT Suicide is the second leading cause of death for adolescents and young adults, with rates of suicide deaths rising in the past two decades. Research examin...
Dendritic Mechanisms Underlying Behaviorally-Relevant Activity in a Descending Auditory Pathway
Project Summary/Abstract Active listening is central to auditory cognition, supporting critical functions such as stream segregation, linguistic analysis and perceptual learning. T...