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201,169 grants found
Showing 198,661 – 198,680 of 201,169 grants
Molecular mechanisms of Werner syndrome helicase in genome stability and aging
PROJECT SUMMARY Progeroid syndromes mimic aging at an accelerated rate and are key to understanding both premature and normal aging. One class of progeroid syndromes results from d...
Unpacking the Multi-level Drivers of Cardiotoxicity Disparities in Breast Cancer Survivors
Abstract The improvement in breast cancer survival is partially due to improvements in treatments. However, these treatments are not without mild to life-threatening side effects....
T cell invasion of the stem cell compartment during immune-mediated GI damage
Despite the importance of intestinal stem cells (ISCs) for epithelial maintenance in the gastrointestinal (GI) tract and the clinical significance of inflammatory intestinal disord...
Genetic determinants of thoracic aortic stiffness and remodeling
Project Summary / Abstract This is an application for a K24 mentoring award for patient-oriented research (POR) from Julio Chirinos, MD, PhD, Associate Professor of Medicine at the...
Redefining hemophagocytic lymphohistiocytosis in hematologic malignancies
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening inflammatory syndrome that is increasingly recognized in patients with malignancies (M-HLH). However, nearly early ev...
The design and evaluation of strategies to implement HIV prevention interventions for pregnant women in community pharmacy settings
PROJECT SUMMARY: Pregnant women in high HIV-burden settings such as western Kenya are at increased risk of acquiring HIV infection during pregnancy. The World Health Organization (...
Humanization of ACE2 and Associated Priming Proteases in New Mouse Models for Downstream Disease and Therapy Investigations of COVID-19
With the initial wave of zoonotic transmission firmly established in the human population worldwide, severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) poses an e...
Accounting for Hidden Bias in Vaccine Studies: A Negative Control Framework
Project Summary / Abstract The proposed research aims to develop novel causal inference methods to resolve unmeasured confounding bias known to plague vaccine effectiveness and saf...
Role of membrane-associated macrophages in health and inflammation
PROJECT SUMMARY/ ABSTRACT Mesenteritis is an inflammatory disorder of mesenteric tissues. It includes mesenteric lipodystrophy (mesenteric fat necrosis), mesenteric panniculitis (c...
Epigenomics of asthma risk factors and clinical subtypes in minority children
PROJECT SUMMARY Asthma is the most common chronic disorder of children, with an estimated 300 million cases worldwide and with significant increases in incidence since the early 19...
Development of high-throughput, high-sensitivity EPR sample handling capabilities for biomedical research
Project Summary/Abstract Electron paramagnetic resonance (EPR) spectroscopy is a critically important technique in biomedical research with a unique ability to detect naturally occ...
Guideline-directed management and therapy (GDMT) for the prevention of postpartum cardiac dysfunction in preeclamptic African American women
Project Summary/Abstract African American women are 60% more likely to have postpartum hypertension and are nearly three times more likely to die from preeclampsia than white women...
Delineating epigenetic coordination of regenerative cell plasticity
Delineating epigenetic coordination of regenerative tissue plasticity Abstract: Tissue damage and repair represent fundamental problems in human health for which few pharmacologica...
Repurposing Endonuclease V for the detection and engineering of adenosine-to-inosine editing
Project Summary/Abstract RNA editing is a widespread strategy employed by cells to post-transcriptionally alter protein sequence and gene expression levels. Adenosine-to-inosine (A...
Discovery and development of artificial nucleic acid ligands to probe cellular interactions
Discovery and development of artificial nucleic acid ligands to probe cellular interactions The regulation followed by measurement of cellular events, such as intercellular communi...
Lateral habenula circuit dysregulation in mild traumatic brain injury
Summary Traumatic brain injury (TBI) contributes to almost 30% of all injury-related deaths in the United States, but the majority of TBI injuries are mild (mTBI). Anxiety, depress...
Microvascular mechanisms of growth restriction after environmental toxicant exposure
ABSTRACT The uterine circulation and placenta are specifically designed to regulate the flow of blood and transport of es- sential nutrients to the fetus. Disruption of maternal he...
Computational Investigations of the Mechanisms Behind Microtubule Catastrophe
PROJECT SUMMARY Microtubules (MTs) constitute the largest components of the eukaryotic cytoskeleton and facilitate a plethora of diverse functions including intracellular transport...
Synergistic Material-Microbe Interface towards Faster, Deeper, and Air-tolerant Reductive Dehalogenation
Project Summary/Abstract Challenges exist in bioremediation of halogenated contaminants, including low donor utilization efficiency and slow dehalogenation, low dehalogenation acti...
Traditional healer-initiated HIV counseling and testing in rural South Africa
Project Summary In South Africa, HIV testing has been undermined by HIV stigma, distrust in the allopathic health system, a preference for traditional medicine, and distance to the...