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201,169 grants found
Showing 198,681 – 198,700 of 201,169 grants
Understanding the Regulation and Biological Roles of Peptidoglycan Hydrolases in Staphylococcus aureus
PROJECT SUMMARY/ABSTRACT The leading cause of antibiotic resistance-associated death in the US is the Gram-positive pathogen Staphylococcus aureus. Many antibiotics used to treat S...
Master epigenetic regulators and retinal degenerative disease
Project summary Retinitis pigmentosa (RP) is the leading cause of inherited blindness afflicting one in every 3500 people. There are no effective treatments for RP, and no prospect...
Disparities in the Use of Oral Anticancer Agents in Kidney Cancer
We have long known that real-world black-white racial disparities have existed in the treatment and outcomes of patients with renal cell carcinoma (RCC). However, it is unclear how...
Wastewater Detection of COVID-19
When faced with a pandemic such as SARS-Coronavirus-2 (SAR-CoV-2), the virus responsible for COVID-19, timely risk assessment and action are required to prevent public health impac...
Use of novel methods to study the biochemical mechanisms of ACTG2 mutations in visceral myopathy
Project Summary The goal of this proposal is to study the mechanisms by which mutations in gamma smooth muscle actin (ACTG2) cause visceral myopathy by building upon newly develope...
Neurodevelopment after postnatal Zika virus infection in infant macaques
PROJECT SUMMARY / ABSTRACT Intense research has focused on the neurologic effects of prenatal Zika virus (ZIKV) infection; however, the consequences of postnatal infection early in...
Mechanisms modulating cell identity in regenerative mammalian epithelia
PROJECT SUMMARY: Significance: Our tissues experience frequent damage from injuries, infections and disease. Many organs in the human body can undergo self-repair to restore their...
Neural Mapping of the Social Landscape
PROJECT SUMMARY Psychiatric disorders that feature social impairment (e.g., Autism Spectrum Disorder) pose a significant health burden in the United States. Attempts to understand...
Efficacy of Mind-Body Approaches for the Treatment of Chronic Pain with Psychological Comorbidity
Chronic pain (CP), defined as persistent (>6 months), non-malignant, musculoskeletal or generalized pain, is a prevalent and costly public health problem. CP is highly prevalent...
Controlling Catheter-Associated Urinary Tract Infections Using Smart Catheters with Rationally Designed Active Topographies
Catheter associated urinary tract infection (CAUTI) is one of the most common healthcare-associated infections (HAIs), with a prevalence of 13 – 15% in the United States. CAUTIs ar...
Structure and Function of Primate Retinal Circuits
An understanding of the normal structure and function of the retina is important to appreciate changes that occur during disease, development and aging. To this end, a longstanding...
Synaptic Architecture and Mechanisms of Direction Selectivity in Primate Retina
A major research challenge for neurobiology is to understand the neural mechanisms that give rise to an extreme diversity of parallel visual pathways and ultimately the contributio...
Targeting Pathologic Spike-Ripples to Isolate and Disrupt Epileptic Dynamics
Project Summary Epilepsy is the world’s most common, serious brain disorder, affecting nearly 50 million people worldwide. For one-third of patients, seizures remain poorly control...
Regulation of the neuroinflammatory response in autoimmune uveitis
Research Abstract: Autoimmune uveitis is a serious sight-threatening condition defined by an autoreactive immune response against the retina and uveal tissues. In autoimmune uveiti...
Defining the Role of Microglia in the Synaptic Rewiring of the Hypothalamus by Early life Adversity
PROJECT SUMMARY:Early-life adversity can profoundly impact an individual’s risk for stress-related emotional disorders including depression, likely by modulating the maturation of...
Community Action to Promote Healthy Environments
PROJECT SUMMARY The overarching goals of the Community Action to Promote Healthy Environments (CAPHE) partnership, established in 2014, are to: (1) develop new knowledge on local c...
Experimental and computational analysis of mechanisms of mitochondrial-cellular ROS crosstalk in the kidney in salt-sensitive hypertension
PROJECT SUMMARY Salt-sensitive hypertension is a significant health problem worldwide and there is a need to understand the underlying molecular mechanisms to enable more effective...
Understanding and leveraging molecular diversity within the phytochrome superfamily
Understanding and leveraging molecular diversity within the phytochrome superfamily. Our proposal focuses on the phytochrome superfamily of photoreceptors. We have a longstanding i...
SCH: Advancing Language-based Analyses of Social Media to Reliably Monitor Variation in Population
This proposal seeks to address a key challenge in public health : the ongoing and fine-grained measurement of population mental health. Currently, in the largest population surveys...
Central Nervous System Plasticity in Airway Disease
PROJECT SUMMARY Exacerbations (asthma attacks) account for nearly one-third of all asthma deaths. Despite psychiatric illness as a risk factor for death from asthma, and many conne...