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201,169 grants found
Showing 198,701 – 198,720 of 201,169 grants
The role of the proximal nephron in salt-sensitive hypertension
The dramatic rise in U.S. fructose consumption mirrors the increase in the incidence of hypertension. More than 17 million Americans consume >20% of their calories as fructose a...
The Striatum and Hippocampus: "Hubs" of White Matter Connections in Parkinson's Disease Cognitive Decline
Due to an aging population and increased lifespan, dementia is an increasing clinical and public health issue.The most common and well-known cause is Alzheimer’s disease (AD), but...
Tuning CAR-T cell function
Abstract Chimeric antigen receptors (CAR) expressed by T cells recognize tumor cells via single chains antibodies and activate T cell cytotoxic machinery and costimulation. In clin...
Mechanism of cardiovascular disease in premenopausal women
PROJECT SUMMARY Suboptimal nutrition is the leading risk factor for death and disability worldwide and accounts for accounts for more than 45% of cardiovascular death in the US. Di...
Nociceptor neuron regulation of gastrointestinal barrier protection and host defense
PROJECT SUMMARY Nociceptor neurons are peripheral sensory neurons that densely innervate the gastrointestinal tract, detecting noxious/harmful stimuli to mediate protective neural...
Mechanisms of Advanced NAFLD Disparities in Hispanics: A Multi-level Analysis
PROJECT SUMMARY/ABSTRACT Nonalcoholic fatty liver disease (NAFLD) leading to nonalcoholic steatohepatitis (NASH) is a major cause of chronic liver disease that may progress to cirr...
Development of high-throughput, high-sensitivity EPR sample handling capabilities for biomedical research
Project Summary/Abstract Electron paramagnetic resonance (EPR) spectroscopy is a critically important technique in biomedical research with a unique ability to detect naturally occ...
Understanding rhythmic gene regulatory mechanisms in the mammalian circadian system
Summary Circadian rhythms are biological, physiological, and behavioral processes that enable organisms to respond to the environmental changes caused by the rotation of the Earth....
The Mid-Atlantic Neuroscience Diversity Scholars (MINDS) Program
PROJECT SUMMARY/ABSTRACT This application is a five-year plan to create a Mid-Atlantic Neuroscience Diversity Scholars (MiNDS) program to bolster the number of underrepresented min...
Mechanistic analysis and allellic genome editing of iPSC-derived dominant LCA model
PROJECT SUMMARY Leber congenital amaurosis (LCA) is a group of devastating early-onset retinal dystrophies affecting roughly 1/50,000 to 1/33,000 newborns. LCA-associated variants...
Analysis of conserved eukaryotic transcription elongation factors
PROJECT SUMMARY/ABSTRACT The long-term objectives of this project are to increase our understanding of eukaryotic transcription elongation, with a focus on histone chaperones. Hist...
Adaptive population codes for flexible visually-guided behaviors
Summary/Abstract Active vision requires encoding and remembering relevant information based on current task goals. Classic accounts posit that sensory encoding, attentional selecti...
Cell cycle dependent mechanisms triggering lumen formation in vivo
SUMMARY STATEMENT: In humans and other vertebrates, motile cilia located in an organ of asymmetry play an important role in cardiac left-right development. Evidence from model orga...
Repeated Ketamine Treatment to Accelerate Efficacy of Prolonged Exposure in PTSD
Only sertraline and paroxetine are currently FDA‐approved to treat PTSD. Other psychotropics are equally limited to provide optimal respond. This efficacy gap may be particularly g...
The Consequence of Impaired Lymphatic Drainage on Rejection in Cardiac Transplantation
PROJECT SUMMARY The leading cause of chronic cardiac transplant rejection—coronary artery vasculopathy (CAV)—remains a major factor limiting long-term survival in heart transplant...
Hydrogen peroxide in endothelial function and dysfunction
The parent R01 grant for this Administrative Supplement is supporting studies of an experimental program that uses chemogenetic approaches to define the roles of reactive oxygen sp...
Understanding the Cardiac Benefits of Exercise at the Cellular and Molecular Level
Project Summary/Abstract Alzheimer’s disease (AD) is the most common form of dementia and its prevalence is increasing as the world population ages. Interestingly, AD shares many r...
Microvascular mechanisms of growth restriction after environmental toxicant exposure
ABSTRACT The uterine circulation and placenta are specifically designed to regulate the flow of blood and transport of es- sential nutrients to the fetus. Disruption of maternal he...
EPPIC-Net Pain Research - Application for Clinical Trial and Related Activities (OT2)
This OT Award funds clinical trials within The Early Phase Pain Investigation Clinical Network (EPPIC-Net). EPPIC-NET is part of the NIH Helping to End Addiction Long-term (HEAL) I...
Synaptic Architecture and Mechanisms of Direction Selectivity in Primate Retina
A major research challenge for neurobiology is to understand the neural mechanisms that give rise to an extreme diversity of parallel visual pathways and ultimately the contributio...