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201,169 grants found
Showing 198,721 – 198,740 of 201,169 grants
Understanding and Targeting Tiam1 in Cancer
Project Summary: Understanding the detailed mechanisms that underlie proliferative signal transduction pathways is of critical importance for developing strategies for diagnosis an...
Dendritic Mechanisms Underlying Behaviorally-Relevant Activity in a Descending Auditory Pathway
Project Summary/Abstract Active listening is central to auditory cognition, supporting critical functions such as stream segregation, linguistic analysis and perceptual learning.To...
Transcriptional control of retinal neuron specification and maturation.
PROJECT SUMMARY/ABSTRACT Amacrine cells (ACs) are the principle inhibitory neurons of the inner retina, with at least 45 morphologically distinct subtypes that can be distinguished...
A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos
Project Summary Physical inactivity is a public health priority for older Latinos with mild cognitive impairment (MCI).MCI, considered the pre-dementia stage of Alzheimer?s disease...
Fatty acid binding-proteins and endocannabinoids in the retina; roles in glial reactivity and reprogramming of Muller glia into progenitor cells
Project Summary: There is a rapidly growing body of evidence that Müller glia can are a source of retinal progenitors to promote neural regeneration.Many studies have demonstrated...
Unraveling strain-level variation in the induction of anti-inflammatory responses in the intestine
PROJECT SUMMARY: Inflammatory bowel disease (IBD) is an increasingly prevalent disease that currently affects ~1.3% of adults in the US.IBD is characterized by chronic inflammatory...
PheMAP: Measured, Automated Profile to Facilitate High Throughput Phenotyping
Electronic health records (EHRs) are a powerful and efficient tool for biological discovery globally.However, a vital step for EHR-based research is valid, accurate, and reliable p...
Role of Protein Kinase C Mutations in Adult T-Cell Leukemia
Abstract - Role of Protein Kinase C Mutations in Adult T-Cell Leukemia Human T-cell leukemia virus type 1 (HTLV-1) is the cause of a T cell lymphoproliferative disorder, designated...
Molecular Mechanisms of Arrestin-Domain Containing Proteins in Metabolism
The arrestin superfamily is composed of two subfamilies: the classical visual/beta-arrestins that were first identified as regulators of G-protein coupled receptor signaling, and t...
Lactoferrin and lysozyme to promote nutritional, clinical, and enteric recovery: A factorial placebo-controlled randomized trial among children with diarrhea and malnutrition
PROJECT SUMMARY/ABSTRACT Diarrhea kills more than half a million children each year and is the third largest contributor to lost disability adjusted life years.While rehydration ad...
Receptor-mediated glucose sensing and skeletal muscle function
PROJECT SUMMARY Skeletal muscle is central to the development of metabolic dysfunction during type 2 diabetes (T2D) and obesity. In addition, these conditions are often accompanied...
The regulation and function of long non coding RNA in ischemic AKI: Role of GSTM3P1
Summary: Acute kidney injury (AKI) is a major renal disease that can be caused by ischemia, sepsis, urinary obstruction and nephrotoxins. It is associated with high mortality clini...
Novel strategies to understand, predict, and prevent vascular toxicity of targeted CML therapies
Molecularly targeted cancer therapies, such as Abl-targeted tyrosine kinase inhibitors (TKIs), have converting many terminal cancers, including chronic myeloid leukemia (CML), into...
Developmental origins and early detection of ADHD and dysregulatory psychopathology
PROJECT SUMMARY: The goal of this proposal is to identify early life predictors of symptoms of ADHD and associated behavioral and emotional problems.To do so children are followed...
Role of membrane-associated macrophages in health and inflammation
PROJECT SUMMARY/ ABSTRACT Mesenteritis is an inflammatory disorder of mesenteric tissues.It includes mesenteric lipodystrophy (mesenteric fat necrosis), mesenteric panniculitis (ch...
Epigenetic dysregulation in diabetic enteric neuropathy
Diabetic gastroenteropathy includes asymptomatic delayed gastric emptying, dyspepsia with or without mildly delayed gastric emptying, or gastroparesis, which is characterized by mo...
Tissue niches for ILC3 development in newborn's lung
PROJECT SUMMARY : Bacterial pneumonia kills more than one million infants around the world each year. Type 3 innate lymphoid cells (ILC3) are critical for lung mucosal defense agai...
A First-in-Class FAP-activated Protoxin to disrupt the Tumor-Stroma Parasitic Cycle fueling lethal Prostate Cancer Progression
Though initially responsive to hormonal therapy, prostate cancer (PCa) invariably progresses to an incurable metastatic castration-resistant state (mCRPC).Additionally, the proport...
Enabling Mass Spectrometry Analysis of the Sulfoproteome
Project Summary Tyrosine O-sulfation, i.e., transfer of a sulfonate group to tyrosine amino acid residues in proteins, is a widespread posttranslational modification (PTM) in eukar...
Does VECAD at Schlemm canal cell-junctions determine IOP and glaucoma risk?
High IOP is a major causal risk factor for glaucoma and is the target of all current glaucoma therapies. This project investigates pathways that control intraocular pressure. Abnor...