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201,169 grants found
Showing 198,761 – 198,780 of 201,169 grants
Sensorimotor learning through adjustments of cortical dynamics
Abstract Extensive research spanning theory, psychophysics, and physiology has investigated how we rely on statistical regularities in the environment to improve our sensorimotor b...
How do CNS fibroblasts regulate the response to neuroinflammation?
ABSTRACT Fibrosis, defined by the deposition of collagen I, is a devastating pathological event that occurs in many organs including the heart, kidney, liver and lung in response t...
Biomaterials-based metabolic rescue of dendritic cells for vaccine design
Abstract The main goal of this proposal is to develop biomaterial-based technologies that can modulate the functions of DCs and T-cells in the draining lymph nodes in the presence...
Controlling Catheter-Associated Urinary Tract Infections Using Smart Catheters with Rationally Designed Active Topographies
Catheter associated urinary tract infection (CAUTI) is one of the most common healthcare-associated infections (HAIs), with a prevalence of 13 ? 15% in the United States.CAUTIs are...
Ceramide-Rich Platforms Functionalize Gemcitabine Uptake
Our data indicate that in select settings activation of acid sphingomyelinase (ASMase)/ceramide signaling in tumor endothelial cells by radiation and certain chemotherapies synergi...
Understanding and targeting bone marrow microenvironment in myelofibrosis
Project summary/Abstract Understanding and targeting abnormal tumor microenvironment is critically important for developing effective therapy. Primary myelofibrosis (PMF) is a form...
Learning principles from the pyrenoid, a phase-separated organelle
PROJECT ABSTRACT Phase separation is an emerging organizing principle for intracellular biology.Processes that are now understood to exploit phase separation include storage of gen...
Early Detection and Diagnosis of Lung Cancer with Endomicroscopy
PROJECT SUMMARY Early diagnosis of lung cancer is critical to patient survival.Unfortunately the vast majority of cases are detected once symptoms arise and the cancer has spread o...
Role of MIF and CD74 in the pathogenesis of emphysema
PROJECT SUMMARY Emphysema is a common pathologic manifestation of Chronic Obstructive Pulmonary Disease (COPD), the fourth leading cause of death in the United States. The most imp...
Understanding the function of histone H3 as an oxidoreductase enzyme
PROJECT SUMMARY This application proposes to investigate the newly discovered function of histone H3 as an oxidoreductase enzyme, catalyzing the reduction of cupric (Cu+2) ions to...
Mechanism of cardiovascular disease in premenopausal women
PROJECT SUMMARY Suboptimal nutrition is the leading risk factor for death and disability worldwide and accounts for accounts for more than 45% of cardiovascular death in the US. Di...
Comprehensive mapping of multimodal chromatin state in single cells
PROJECT SUMMARY Many non-Mendelian (polygenic) human genetic diseases involve multiple causal loci in noncoding regions of the genome, implicating mutations in regulatory elements...
Neural mechanisms of active vision in the fovea
Neural mechanisms of active vision in the fovea In many ways human vision is like a camera, with a lens that forms an image on a spatially arranged sensor (the retina). However, it...
Genetic determinants of thoracic aortic stiffness and remodeling
Project Summary / Abstract This is an application for a K24 mentoring award for patient-oriented research (POR) from Julio Chirinos, MD, PhD, Associate Professor of Medicine at the...
Understanding the Cardiac Benefits of Exercise at the Cellular and Molecular Level
Project Summary/Abstract Heart failure (HF) is a growing cause of morbidity and mortality.Despite the best available treatments, prognosis remains poor for many HF patients undersc...
Uptake and Patterns of Use of the IQOS Heated Tobacco System by US Smokers
Project Abstract On April 30, 2019, the U.S.Food and Drug Administration (FDA) issued a marketing order authorizing the IQOS ?Tobacco Heating System? (IQOS), manufactured by Philli...
Clinical Translation of Targeted and Noninvasive Ultrasonic Propofol Uncaging
PROJECT SUMMARY .There are numerous clinical needs for a technology that can modulate nervous system activity noninvasively and focally, with clinically-relevant spatial and tempor...
Non-invasive, Transgene-free, on-demand Pharmacological Modulation of Neural Activity
PROJECT SUMMARY/ABSTRACT Cell-type specific manipulation of neural circuits is required for the treatment of neurological disorders such as epilepsy and autism. Existing technologi...
Itch Ubiquitin Ligase and Germinal Center B cells
PROJECT SUMMARY/ABSTRACT The NIH estimates that up to 23.5 million Americans suffer from autoimmune disease, driven in large part by germinal center (GC)-derived pathologic autoant...
Treatment of Veterans with Heart Failure with Reduced Ejection Fraction with Probenecid
Heart failure with reduced ejection fraction (HFrEF) is a common cause for admission within the Veterans Affairs (VA) Health Care System.It is associated with severe impairment of...