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201,169 grants found
Showing 198,781 – 198,800 of 201,169 grants
Repeated Ketamine Treatment to Accelerate Efficacy of Prolonged Exposure in PTSD
Only sertraline and paroxetine are currently FDA?approved to treat PTSD. Other psychotropics are equally limited to provide optimal respond. This efficacy gap may be particularly g...
Pharmacological Npt2a inhibition as a treatment for hyperphosphatemia in chronic kidney disease
The precise regulation of the body's phosphate homeostasis is a critical task.Treatment of hyperphosphatemia, which becomes inevitable in later stages of chronic kidney diseas...
Pathologic Signaling Pathways in AML Cells
Abstract: Acute myeloid leukemia (AML) is a serious blood cancer that affects United States Veterans and other individuals. Multiple studies have demonstrated that active signaling...
Novel causal inference methods to inform clinical decision on when to discontinue symptomatic treatment for patients with dementia
PROJECT SUMMARY/ABSTRACT Appropriate use of acetylcholinesterase (AChEIs) and memantine can meaningfully improve the health outcomes and quality of life among people with Alzheimer...
Role of intermittent activation of parathyroid hormone receptor in exercise-induced vascular calcification
PROJECT SUMMARY/ABSTRACT Vascular calcification, especially coronary artery calcification (CAC), is associated with increased risk of cardiovascular disease, whereas regular physic...
Neighborhoods, Sexual Orientation, Race/Ethnicity & Smoking Across the Adult Lifespan: A Multilevel Intersectional Assessment
Abstract/Project Summary Recent estimates indicate that 11.3 million adults in the United States identify as sexual and/or gender minorities (SGMs) and of these 2.3 million are age...
The Mid-Atlantic Neuroscience Diversity Scholars (MINDS) Program
PROJECT SUMMARY/ABSTRACT This application is a five-year plan to create a Mid-Atlantic Neuroscience Diversity Scholars (MiNDS) program to bolster the number of underrepresented min...
Superresolution Light Sheet Microscopy for imaging model organisms with 200nm resolution
Project Summary Light Sheet Microscopy has become an essential tool for investigating a wide variety of biological problems from developmental questions to mapping neural circuits....
The Pdx1-recruited Swi/Snf chromatin remodeling complex regulates endocrine cell expansion and differentiation in vivo
PROJECT SUMMARY/ABSTRACT Pancreatic ?-cells within the islets of Langerhans are required for glucose-stimulated insulin secretion and glucose homeostasis.Dysfunctional ?-cell activ...
Reconstructing positional information in the eye from scRNA-seq and relating it to signal transduction
PROJECT SUMMARY This proposal is a new application entitled Reconstructing positional information in the eye from scRNA-seq and relating it to signal transduction.The question of h...
CMA: Network plasticity in acquired epileptogenesis
Project Summary/ Abstract: Temporal Lobe Epilepsy (TLE) is the most frequent type of post-traumatic epilepsy, causing significant morbidity in the veteran population.Approximatel...
Opioid Support and Risk Reduction Online Platform
Project Summary This proposal seeks to determine the feasibility, acceptability, and preliminary efficacy of developing an online support and risk reduction platform to prevent opi...
mTOR-Mediated Desaturation of Fatty Acids in Hepatic Insulin Resistance.
Discharged members of the US Armed Services are at an increased risk of metabolic disease which is exemplified by the prevalence of type 2 diabetes mellitus (T2DM) affecting an est...
CMA: Network plasticity in acquired epileptogenesis
Temporal lobe epilepsy (TLE) is the most common form of epilepsy in adults and a major source of disability in the veteran population as it is frequently caused by war-time head in...
Preoptic/Hypothalamic Mechanisms of Sleep-Wake Regulation
ABSTRACT Chronic sleep disturbance is a frequent and challenging problem of human aging.In the US an estimated 39.6 million people including 8.5 million Veterans are aged 65 or old...
Defining Breath VOC Biomarkers to Improve Respiratory Health of Exposed Veterans
The goal of this resubmitted application is to define signature exhaled breath volatile organic compounds (VOCs) in veterans exposed to toxicants and to develop an effective portab...
Subthalamic deep brain stimulation to modulate vestibular heading perception in Parkinson’s disease.
Parkinson?s Disease (PD) is a common neurodegenerative disorder affecting human movements. PD is not just a motor disease. It also results in impaired multi-sensory processing that...
Host factors affecting susceptibility to Candida auris.
This VA Merit research project aims to define host factors associated with mucosal infection by an emerging multi-drug resistant human fungal pathogen, Candida auris.Most human fun...
Colon cancer nanotherapy targeting STRAP
Although activation of the Ras/Raf/MEK/ERK pathway is involved in cell growth, inhibition of apoptosis, induction in stem-like phenotype, and drug resistance, little is known about...
Role of skin injury-induced inflammation in wound healing
PROJECT SUMMARY Chronic skin wounds like diabetic foot ulcers (DFU) are a serious medical problem in Veterans.Up to one third of patients with diabetes develop DFU, a leading cause...