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201,169 grants found
Showing 198,841 – 198,860 of 201,169 grants
Defining the genetic landscape of nanophthalmos and the role of MYRF
Defining the genetic landscape of nanophthalmos and the role of MYRF ABSTRACT: Nanophthalmos is part of a spectrum of disorders characterized by a small eye and resultant high hype...
ROS Targeted Therapy for Lethal Prostate Cancer
PROJECT SUMMARY Prostate cancer (PC) is the second leading cause of cancer mortality in American men.Current therapeutics only show marginal efficacy and are often associated with...
Inhibition of CaMKK2 sensitizes rectal cancers to radiation therapy
Abstract In the United States, colon cancer and rectal cancer are the third most common cancer diagnosed in both men and women.The standard of care for stage II-III rectal cancer i...
Mitochondrial-targeted antioxidant supplementation for improving age-related vascular dysfunction in humans
Project Summary The vast majority of cardiovascular diseases (CVD) occur in men and women ≥60-years of age. Changes in the demographics of aging in the U.S. predict progressive inc...
Motherhood Biographies and Midlife Women's Health
Abstract Research shows widening health disparities among midlife women since the mid-1980s. However, the mechanisms through which these health gradients operate are not fully know...
GATA Factor Mechanisms in Erythroid Regeneration
ABSTRACT Erythropoiesis, the production of red blood cells (RBCs), is fine-tuned to meet physiological demands. During regeneration or “stress erythropoiesis” caused by anemia, a s...
Determing the genetic basis of responses to biomechanical strain in an in vitro model of osteoarthritis
Osteoarthritis (OA), a degenerative joint disorder characterized by articular cartilage damage and alterations to the structure of subchondral bone, is the most common joint diseas...
Connecting AMD SNPs to Functions Using Allele-specific Interactions
PROJECT SUMMARY. Age-related Macular Degeneration (AMD) is a retinal neurodegenerative disease that is a major cause of vision loss among the elderly worldwide. Although anti-VEGF...
Next generation deep tissue quantitative optical imaging
PROJECT SUMMARY Nearly 20-years of clinical research has shown that near-infrared optical imaging based upon frequency domain diffuse optical spectroscopy (FD-DOS) can be a powerfu...
Machine Learning Models for Identifying Neural Predictors of TMS Treatment Response in MDD
Transcranial magnetic stimulation (TMS) is an effective and easy-to-tolerate treatment for major depressive disorder (MDD). TMS is costly and time-intensive so identifying markers...
Novel population-genetic methods for localizing targets of natural selection in diverse human genomes
PROJECT SUMMARY. The PI's research program in population genetics focuses on the coalescent-based inference of population his- tories from whole genomes, and the determination...
Cellular and molecular mechanisms underlying DDX3X syndrome
Abstract Mutations in DDX3X are strongly associated with autism spectrum disorder (ASD), and may account for 1-3% of unexplained developmental delay (DD) in females, making this on...
Sensorimotor learning through adjustments of cortical dynamics
Abstract Extensive research spanning theory, psychophysics, and physiology has investigated how we rely on statistical regularities in the environment to improve our sensorimotor b...
Genetic and molecular correlates of white matter pathology in Alzheimers disease
PROJECT SUMMARY: Although Alzheimer's disease (AD) is typically defined by the accumulation of beta- amyloid and hyperphosphorylated tau proteins, synaptic loss and neuronal d...
MICROBIOTA-DEPENDENT CONTROL OF CLOSTRIDIUM DIFFICILE: THE ROLE OF ACETATE AND IL-22 BINDING PROTEIN
PROJECT SUMMARY The overall goal of this application is to establish avenues through which we can harness the intestinal microbiota to enhance mucosal immune responses against Clos...
Rapid evolution of pigmentation in D. melanogaster: from cis regulation to phenotype
PROJECT SUMMARY Rapid evolutionary adaptation is a foundational process in biology and at the core of many issues facing humanity including cancer, bacterial and viral diseases, ev...
Genetic determinants of thoracic aortic stiffness and remodeling
Project Summary / Abstract This is an application for a K24 mentoring award for patient-oriented research (POR) from Julio Chirinos, MD, PhD, Associate Professor of Medicine at the...
Interplay Between Nuclear Organization and Function
PROJECT SUMMARY/ABSTRACT Goals: Peri-Centromeric Heterochromatin (PCH) is required for genome stability/DNA repair, chromosome pairing, nuclear architecture, and transposon and gen...
Characterization of biased airway smooth muscle TAS2R agonists for treating asthma
Asthma remains a major public health issue worldwide, affecting all ages and ethnicities, with 50% of patients experiencing inadequate control of the disease. Constricted airways f...
Structural Biology of Dopamine Signaling
Abstract Human dopamine signaling pathway induces and facilitates dopamine neurotransmission through the mesolimbic dopaminergic pathway, which modifies reward-related behaviors an...