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201,169 grants found
Showing 198,861 – 198,880 of 201,169 grants
Biomarker Signatures for Delayed Cerebral Ischemia and Outcome Following Subarachnoid Hemorrhage
Abstract Subarachnoid hemorrhage (SAH) accounts for 5% of all strokes, has a high mortality and the cost to society is similar to ischemic stroke since subjects are much younger. T...
Characterizing the effects of cis-regulatory variation on patient outcomes and treatment response in Multiple Myeloma
ABSTRACT Multiple Myeloma (MM) is a malignancy of plasma cells and the second most common hematological cancer accounting for 2% of cancer deaths. MM is associated with a poor prog...
Biomaterials-based metabolic rescue of dendritic cells for vaccine design
Abstract The main goal of this proposal is to develop biomaterial-based technologies that can modulate the functions of DCs and T-cells in the draining lymph nodes in the presence...
Elucidating Oncogenic Mechanisms Underlying Wilms Tumor Using Kidney Organoids
PROJECT SUMMARY/ABSTRACT Wilms tumor is the most common pediatric kidney cancer. Blastemal-predominant tumors are classified as high-risk and have demonstrated resistance to chemot...
CD28 Regulation of Alternative Splicing Changes in Human T cells
Project Summary Alternative splicing consists of exons that are selectively included or excluded from the mature mRNA transcript. In fact, most protein encoding genes, approximatel...
Dissociable neural mechanisms of reactive versus appetitive aggression
Project Summary Maladaptive aggression characterizes - or is comorbid with - many neuropsychiatric illnesses, and can have devastating effects on individuals, their caretakers, and...
Exploiting convergent evolution to design biomarker extraction tools for the prediction of therapeutic response in cancer
PROJECT SUMMARY/ABSTRACT The effective treatment of drug resistant tumors represents one of the greatest unmet needs in oncology research. The evolution of therapeutic resistance i...
1/3 Genomics of Schizophrenia in the South African Xhosa
PROJECT DESCRIPTION The goal of this international collaborative project, in response to PAR-20-027, is to characterize the genetic architecture of schizophrenia in the Xhosa popul...
Ceramide-Rich Platforms Functionalize Gemcitabine Uptake
Our data indicate that in select settings activation of acid sphingomyelinase (ASMase)/ceramide signaling in tumor endothelial cells by radiation and certain chemotherapies synergi...
Repurposing an FDA approved Drug, B-Raf Kinase Inhibitor Dabrafenib for Protection from Cisplatin- and Noise- induced Hearing Loss
Abstract Hearing loss caused by noise, aging and chemotherapy affects seven hundred million people worldwide, but there are no FDA-approved drugs to prevent it. This research will...
Understanding the mechanisms underlying R-loop biogenesis and resolution in mammals
Project summary During transcription, the nascent RNA can anneal with the template DNA strand behind the advancing RNA polymerase and cause the formation of alternative DNA structu...
Ultraviolet Photodissociation Mass Spectrometry for Characterization of Biological Molecules
Abstract. Understanding the functions of lipids, proteins and even larger macromolecular assemblies depends on deciphering complex structures of individual molecules as well as dec...
Enabling Mass Spectrometry Analysis of the Sulfoproteome
Project Summary Tyrosine O-sulfation, i.e., transfer of a sulfonate group to tyrosine amino acid residues in proteins, is a widespread posttranslational modification (PTM) in eukar...
Role of MIF and CD74 in the pathogenesis of emphysema
PROJECT SUMMARY Emphysema is a common pathologic manifestation of Chronic Obstructive Pulmonary Disease (COPD), the fourth leading cause of death in the United States. The most imp...
Defining the function and mechanism of regulatory ribosomal ubiquitylation
PROJECT SUMMARY Protein homeostasis (proteostasis) relies on the continual surveillance and removal of defective translation products resulting from the relatively high error rates...
A Leukemia Cell-Specific Coiled-Coil Protein for Treatment of Chronic Myeloid Leukemia
Project Summary/Abstract The long-term goals of this proposal are to explore the protein dimerization interface as an area for therapeutic intervention. Protein dimerization/oligom...
Enabling Technology to Screen and Quantify Sialylated Structures for Activity Against Viral Enzymes and Receptors
Sialylated glycans are involved in complex regulation and signaling and play a critical role in disease. In the virus life cycle, receptor binding and sialic acid cleavage to facil...
Using nicotine to reverse age-related auditory processing deficits
Age-related decline in central auditory function significantly affects quality of life in the elderly, with impaired speech perception leading to increased risk for depression, soc...
2/3 Genomics of Schizophrenia in the South African Xhosa
PROJECT DESCRIPTION The goal of this international collaborative project, in response to PAR-20-027, is to characterize the genetic architecture of schizophrenia in the Xhosa popul...
Understanding and targeting bone marrow microenvironment in myelofibrosis
Project summary/Abstract Understanding and targeting abnormal tumor microenvironment is critically important for developing effective therapy. Primary myelofibrosis (PMF) is a form...