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201,169 grants found
Showing 198,881 – 198,900 of 201,169 grants
The role of Bik in the replication and severity of influenza A virus
Influenza A virus (IAV) is responsible for seasonal epidemics that results in severe respiratory illness and deaths worldwide, costing billions of dollars annually in the U.S. alon...
Translating Hyperpolarized 13C Metabolic MRI to Predict Renal Tumor Aggressiveness
Project summary: This project aims to clinically translate hyperpolarized (HP) 13C pyruvate MRI as an innovative metabolic imaging approach for noninvasive prediction of renal tumo...
A system for long-term high-resolution 3D tracking of movement kinematics in freely behaving animals
PROJECT SUMMARY The aim of this proposal is to deliver an innovative and easy-to-use experimental platform for measuring and quantifying naturalistic behaviors of mammalian animal...
Coupled Protons and Electrons in Biological Systems
Project Summary/Abstract Controlling the movement of electrons and protons is critical for a wide range of biological processes, including cellular respiration, DNA biosynthesis, a...
Novel small molecule USP7 Inhibitors for p53 activation and cancer therapy
Project Summary: The long-term objective of this project is to develop a novel targeted therapy for human cancers by reactivating the tumor suppression pathways. Although p53 is fr...
The Impact of Aging on Prostate Cancer with Age-Related Disruption of Th17/Treg Axis
Project Summary/Abstract: Prostate cancer (PCa) is particularly important in elderly men because of the high incidence and prevalence of disease and mortality in this group of pati...
Hydrogen peroxide in endothelial function and dysfunction
The proposed studies will use new biosensors and novel chemogenetic approaches to identify the molecular mechanisms whereby reactive oxygen species (ROS) regulate nitric oxide (NO)...
Identifying Novel Therapeutics for High Risk Medulloblastoma Patients
ABSTRACT Among pediatric brain tumors, medulloblastoma is the most common form. While most children with medulloblastoma can be cured, ~25% of these kids will die, and those that s...
Predicting and Preventing Ventilator-Induced Lung Injury
Project Summary Acute respiratory distress syndrome (ARDS) is a rapid onset respiratory failure that is caused by factors ranging from pneumonia to sepsis. The impact of ARDS is su...
Macrophage Regulation of Immune Pathogenesis of Biliary Atresia
PROJECT SUMMARY: Candidate and Career Development: Dr. Taylor is a pediatric hepatologist and Assistant Professor of Pediatrics at Northwestern University. She has maintained a str...
Impact of Circulating Myeloid Cell Clusters on Anti-Tumor Immunity
Durable outcomes in subsets of solid cancer patients treated with immune checkpoint inhibitors (ICI) or adoptive cell transfer (ACT) immunotherapy has driven interest in gaining a...
Neuromodulation of long-term sequelae of ischemic acute kidney injury
Project Summary Acute kidney injury (AKI) is recognized as a major risk for progressive chronic kidney disease (CKD). However, the mechanism by which AKI leads to fibrogenesis and...
The Role of Follistatin Like Protein 1 in the cardiac inflammation of Kawasaki Disease
Project Summary/Abstract: Kawasaki disease (KD), a predominantly coronary vasculitis of childhood, is the most common cause of acquired heart disease of childhood in the developed...
Mechanisms regulating neural stem cell maintenance in the dentate gyrus
Project Summary Dr. Bond’s primary career goal is to run her own independent academic research group broadly investigating how principles of brain development can be used to unders...
Identifying Protein-Protein Network Interactions between COPD Susceptibility Genes
PROJECT SUMMARY Genome-wide association studies (GWAS) of complex diseases like COPD have identified many genomic regions associated with disease, but the molecular mechanisms by w...
The Role of the Microbiome and Notch Signaling in Esophageal Adenocarcinoma
PROJECT SUMMARY The incidence of esophageal adenocarcinoma (EAC) has risen 10-fold over the past half century and continues to have a dismal prognosis. Known modifiable risk factor...
Mycobacterial Lung Diseases in Virginia: sequencing and clinical determinants of relapse and outcome
PROJECT SUMMARY / ABSTRACT Nontuberculous mycobacterial lung diseases, primarily due to M. avium complex (MAC), is an increasing clinical problem nationwide and now overtakes domes...
Molecular mechanisms and functions of global chromatin control
Project Summary/Abstract The long term goal of the proposed study is to determine, at the molecular level, mechanisms and functions of chromatin regulation at a global level. Chrom...
REACH Pipeline Summer Research Experience for Minority and Underrepresented High School and Undergraduate Students
REACH is an 8-week pipeline summer course for minorities and underrepresented college and high school students interested in careers in neuroscience. Developed, together with Drs.J...
Interplay between AMPK and Hippo Signaling Regulates Ocular Antiviral Response to Zika virus infection
PROJECT SUMMARY: Zika virus (ZIKV) is a teratogenic human pathogen that causes congenital eye and brain diseases. Affected babies exhibit vision impairment and associated ocular pa...