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201,169 grants found
Showing 198,921 – 198,940 of 201,169 grants
Novel strategies to understand, predict, and prevent vascular toxicity of targeted CML therapies
Molecularly targeted cancer therapies, such as Abl-targeted tyrosine kinase inhibitors (TKIs), have converting many terminal cancers, including chronic myeloid leukemia (CML), into...
Inside-out construction of the biliary system
Project Summary The intrahepatic biliary tree functions to drain bile from hepatocytic canaliculi away from the liver. Congenital or acquired abnormalities in the formation and pat...
Synthesis and Chemical Biology of Bioactive Natural Products
Project Summary/Abstract This proposal describes our program focused on the development of novel chemical reactions for complex molecule synthesis, innovative strategies for molecu...
A Human-Mimetic AI System for Automatic, Passive and Objective Dietary Assessment
A Human-Mimetic AI System for Automatic, Passive and Objective Dietary Assessment Unhealthy diet is strongly linked to risks of chronic diseases, such as cardiovascular diseases, d...
Digital Phenotyping To Screen For Early Childhood Internalizing Disorders
ABSTRACT Childhood anxiety and depression are common, impairing, and have the potential to disrupt development well into adulthood. Pediatricians need mental health screening tools...
Therapeutic Targeting Mitochondrial C1 Metabolism
ABSTRACT Metabolic reprogramming is an important hallmark of cancer. Of the altered metabolic pathways associated with malignancy, one-carbon (C1) metabolism is particularly notabl...
Accounting for Hidden Bias in Vaccine Studies: A Negative Control Framework
Project Summary / Abstract The proposed research aims to develop novel causal inference methods to resolve unmeasured confounding bias known to plague vaccine effectiveness and saf...
Functional Significance of Ferritin Light Chain in Sepsis-associated Kidney Injury
Sepsis accounts for nearly 50% of acute kidney injury (AKI) in the intensive care unit and significantly impacts mortality. However, therapy for sepsis-associated AKI (SA-AKI) has...
Epigenetic dysregulation in diabetic enteric neuropathy
Diabetic gastroenteropathy includes asymptomatic delayed gastric emptying, dyspepsia with or without mildly delayed gastric emptying, or gastroparesis, which is characterized by mo...
Investigating novel host factors promoting human papillomavirus infection
Project Summary/Abstract: Human papillomavirus (HPV) infects nearly 80 million U.S. adults, and is the primary cause of cervical, anogenital, and oropharyngeal cancers. Unfortunate...
Learning principles from the pyrenoid, a phase-separated organelle
PROJECT ABSTRACT Phase separation is an emerging organizing principle for intracellular biology. Processes that are now understood to exploit phase separation include storage of ge...
Mechanisms of retinal degeneration in neuroinflammatory demyelinating diseases
An important question in the field of multiple sclerosis (MS) is whether myelin/axonal damage in the white matter facilitates neuronal cell body loss in the gray matter, or results...
Large-Scale Mapping of Striatal Dynamics during Perceptual Decision Making
Project Summary/Abstract Large-Scale Mapping of Striatal Dynamics during Perceptual Decision Making The accumulation of evidence over time is a critical aspect of many types of dec...
Fatty acid binding-proteins and endocannabinoids in the retina; roles in glial reactivity and reprogramming of Muller glia into progenitor cells
Project Summary: There is a rapidly growing body of evidence that Müller glia can are a source of retinal progenitors to promote neural regeneration. Many studies have demonstrated...
Regulatory mechanisms of the Hsp90 chaperone machinery
PROJECT SUMMARY The molecular chaperone Heat Shock Protein-90 (Hsp90) is essential for the folding and activity of an array of `client' proteins involved in signal transductio...
Molecular functions of human zinc transporter-8 in pancreatic beta cells
The long-term goal of our research is to understand how the molecular and cellular functions of zinc transporter-8 (ZnT8) modulate pathophysiologic responses of human pancreatic be...
Rhythmogenic states of the respiratory network reveal differential opioid sensitivity
PROJECT SUMMARY Opioid induced respiratory depression (OIRD) is the major cause of death associated with opioid use and drugs of abuse. Although the mortality risk increases in a d...
Synaptic transmission at retinal ribbon synapses
In sensory cells of the eye and inner ear the neurotransmitter glutamate is released at active zones in a graded and continuous manner. These cells have evolved specialized structu...
Chemotherapy-driven evolution of the vascular secretome and its role in therapeutic resistance
PROJECT SUMMARY Our continued inability to develop selective therapies that prevent the emergence of disseminated breast tumor cells into lethal metastases necessitates new approac...
Role of the circadian rhythm on endocannabinoid response to an acute stress
Project Summary Cardiovascular (CV) disease is the leading cause of death in the US. Night and rotating shift work, ~20% of the labor force, is associated with a greater incidence...