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201,169 grants found
Showing 198,961 – 198,980 of 201,169 grants
The Role of the Microbiome and Notch Signaling in Esophageal Adenocarcinoma
PROJECT SUMMARY The incidence of esophageal adenocarcinoma (EAC) has risen 10-fold over the past half century and continues to have a dismal prognosis. Known modifiable risk factor...
Addressing Social Determinants of Health to Improve Diabetes Prevention Program Outcomes Among Underserved African Americans
PROJECT SUMMARY African Americans (AAs) are disproportionately burdened by diabetes mellitus (DM) with rates twice as high as Whites (13% vs 7.5%), and increased rates of DM-relate...
HIGH FIELD MRI AND THE LABYRINTH: VESTIBULAR STIMULATION AND NEW IMAGING TECHNIQUES
ABSTRACT Dr. Bryan Ward is an assistant professor in the department of Otolaryngology-Head & Neck Surgery at the Johns Hopkins School of Medicine, where he is dedicating his cl...
Estrogen Receptor Signaling in the Expression of Respiratory Motor Plasticity
PROJECT SUMMARY/ABSTRACT The respiratory control system displays a remarkable capacity for neuroplasticity, imparting flexibility of breathing in response to changing physiological...
Deep learning models to predict primitive streak formation in human development
Project Summary Congenital birth defects affect an estimated 3% of live births. To develop effective treatment strategies, a thorough understanding of early human development is ne...
Use of novel methods to study the biochemical mechanisms of ACTG2 mutations in visceral myopathy
Project Summary The goal of this proposal is to study the mechanisms by which mutations in gamma smooth muscle actin (ACTG2) cause visceral myopathy by building upon newly develope...
Motherhood Biographies and Midlife Women's Health
Abstract Research shows widening health disparities among midlife women since the mid-1980s. However, the mechanisms through which these health gradients operate are not fully know...
Naturalistic Eye Movements as Clinical Markers of Everyday Cognition in Older Adults
PROJECT SUMMARY/ABSTRACT Loss of independence in the ability to successfully complete activities of daily living (ADL), such as meal preparation, is a core diagnostic criterion of...
Experience-dependent Cellular Plasticity Mechanisms
Brain activity is essential for the development and plasticity of neurons and circuits, however our understanding of the mechanisms by which activity generates functional circuits...
Mechanistic study of the role of autism spectrum disorder risk genes in hippocampal CA1 population dynamics during learning and memory
PROJECT SUMMARY/ABSTRACT The hippocampus is a critical brain region for various types of learning and memory, and one powerful paradigm to investigate hippocampal function in assoc...
Kidney PCSK9 in nephrotic syndrome
Summary / Abstract (max 30 lines): Nephrotic syndrome is a major manifestation of human glomerular disease, and patients with this condition develop large amounts of protein in the...
Genome-wide structure-based analysis of protein-protein interactions and networks
Project Summary Our lab works in the general area of computational structural biology although it also includes an experimental component. We carry out theoretical and computationa...
Extrinsic regulation of primitive, myeloid-biased hematopoietic stem cells by Semaphorin 4a
ABSTRACT Despite substantial experimental evidence for the important functional role of myeloid-biased HSC (myHSC) in stress, inflammation and aging, the mechanisms which control m...
Mechanisms and evolutionary consequences of transposon strategies to counteract host silencing
PROJECT SUMMARY Harboring active transposable elements (TEs) imposes a substantial mutational burden on the host genome. To reduce this burden, most organisms have evolved sophisti...
The regulation and function of long non coding RNA in ischemic AKI: Role of GSTM3P1
Summary: Acute kidney injury (AKI) is a major renal disease that can be caused by ischemia, sepsis, urinary obstruction and nephrotoxins. It is associated with high mortality clini...
Vascular calcification and atherosclerosis
Project Summary/Abstract Cardiovascular disease (CVD) is the leading cause of death in the U.S., with the annual total cost of care estimated at $351 billion. Vascular calcificatio...
SPHINGOLIPID BIOLOGY OF MACROPHAGE IN CORONARY ATHEROSCLEROSIS DEVELOPMENT AND PROGRESSION
Inflammatory macrophages play a key role in the development and progression of the atherosclerosis, leading to myocardial infarction (MI). Sphingolipids are both membrane component...
Molecular and Cellular Pathogenesis of Kidney Disease in Sickle Cell Disorders
PROJECT SUMMARY/ABSTRACT Kidney disorders comprising acute kidney injury (AKI), chronic kidney disease (CKD) and end-stage renal disease (ESRD) account for significant morbidity an...
Mechanistic analysis and allellic genome editing of iPSC-derived dominant LCA model
PROJECT SUMMARY Leber congenital amaurosis (LCA) is a group of devastating early-onset retinal dystrophies affecting roughly 1/50,000 to 1/33,000 newborns. LCA-associated variants...
Control of Colitogenic Th17 cells by Vitamin D Receptor Signaling
PROJECT SUMMARY Vitamin D (Vit D) deficiency is estimated to affect over 1 billion people worldwide and is now considered a global health crisis. In addition to maintaining calcium...