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201,169 grants found
Showing 199,001 – 199,020 of 201,169 grants
Development of an artificial intelligence-driven, imaging-based platform for pretreatment identification of extranodal extension in head and neck cancer
Project Summary. The goal of this project is to develop, optimize, and evaluate an artificial intelligence (AI)- driven, medical imaging platform that utilizes computed tomography...
Experience-dependent Cellular Plasticity Mechanisms
Brain activity is essential for the development and plasticity of neurons and circuits, however our understanding of the mechanisms by which activity generates functional circuits...
Optimization of Lead BKIs for Cryptosporidiosis Therapy
ABSTRACT: Optimization of Lead BKIs for Cryptosporidiosis Therapy The broad, long-term objective of this research is to develop a therapeutic for treatment of Cryptosporidium infec...
Direct chemical control of the hematopoietic master transcription factor PU.1
PROJECT SUMMARY/ABSTRACT: Direct control of the hematopoietic master transcription factor PU.1 Hematopoiesis, the process by which all lineages of blood cells are derived, is under...
ERβ repurposes EZH2 to suppress oncogenic NFκB signaling in TNBC
PROJECT SUMMARY/ABSTRACT Breast cancer remains the most commonly diagnosed cancer in women and is the second leading cause of cancer-related deaths among women. Triple Negative Bre...
Neural Mapping of the Social Landscape
PROJECT SUMMARY Psychiatric disorders that feature social impairment (e.g., Autism Spectrum Disorder) pose a significant health burden in the United States. Attempts to understand...
Boston Latino Aging Study (BLAST): Understanding Alzheimer's risk and biomarkers in older Latinos
Latinos are the fastest growing subpopulation of older adults in the U.S.A. and have a greater prevalence of Alzheimer’s disease (AD) than non-Latino whites (1). Despite this, our...
Probing cytosolic nucleic acid sensing pathways in cancer
ABSTRACT The ability of mammalian cells to elicit inflammation is central to many processes including embryogenesis, wound healing, tissue regeneration, and cancer metastasis. A ma...
Astrocyte Calcium Signaling in Neuropathic Pain
PROJECT SUMMARY Chronic pain is a hallmark of many disease conditions, including nerve and spinal cord injury. Current mainstays of pain management include analgesics and anestheti...
Discovery of myeloid immune features predictive of response to cancer immunotherapy in prostate cancer
PROJECT SUMMARY/ABSTRACT Cancer immunotherapy has been a revolutionary antitumor treatment and is approved to treat a plethora of cancer types. However, in solid tumors the respons...
Function of Kdm4dl-mediated heterochromatin removal in the preimplantation mouse embryo
PROJECT ABSTRACT This project will investigate the function of a currently unstudied histone demethylase, Kdm4dl, in the mouse preimplantation embryo. Many others have shown the de...
Uptake and Patterns of Use of the IQOS Heated Tobacco System by US Smokers
Project Abstract On April 30, 2019, the U.S. Food and Drug Administration (FDA) issued a marketing order authorizing the IQOS “Tobacco Heating System” (IQOS), manufactured by Phill...
Abscission regulation of corticogenesis
Abstract: In order for the brain to develop with proper size and structure, neural stem cells (NSCs) at early ages must make proliferative divisions and maintain their stemness to...
Elucidation of a Eukaryotic Chemorepulsion Mechanism
The directed movement of eukaryotic cells away from a source of a chemorepellent appears to play a major role in development and the resolution of inflammation, but very little is...
Aspirin to prevent cardiac dysfunction in preeclampsia
ABSTRACT Preeclampsia (PE) is a disease of late pregnancy characterized by hypertension and organ damage, which not only increases peripartum morbidity but is associated with the p...
Leveraging implementation and behavioral science to reduce harmful overuse of diagnostic testing in critically ill children
Project Abstract Overtreatment – health care in which the benefit does not outweigh risks – accounts for up to $200 billion annually in the United States, and is associated with wo...
Red Blood Cells shuttle beta amyloid between brain and heart: implications for the pathogenesis and the progression of Alzheimer's and Cardiomyopathy
Abstract Alzheimer disease (AD) is the most frequent form of dementia causing a significant reduction of quality of life of affected patients. In the brains of AD patients, β-amylo...
Tissue niches for ILC3 development in newborn's lung
PROJECT SUMMARY : Bacterial pneumonia kills more than one million infants around the world each year. Type 3 innate lymphoid cells (ILC3) are critical for lung mucosal defense agai...
Novel gastrocnemius muscle characteristics in peripheral artery disease patients associated with impaired functional performance
Lower extremity peripheral artery disease (PAD) significantly affects aging populations and results in functional impairment. Although the clinical importance of finding efficaciou...
Linear energy transfer (LET) dependencies for understanding pancreatic tumor control and relevant molecular endpoints in support of RBE-based heavy-ion radiotherapy
This proposal brings together a unique interdisciplinary team with complementary expertise in high-LET radiobiology, pancreatic cancer research, and high-LET physics. It leverages...