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201,169 grants found
Showing 199,061 – 199,080 of 201,169 grants
IL-1Beta-Induced Retinal Iron Accumulation in Age-Related Macular Degeneration
PROJECT SUMMARY Age-related macular degeneration (AMD) is the most common cause of irreversible blindness in the United States. AMD is characterized by the death of photoreceptors...
The isolated impacts of alcohol policies on birth outcomes
Project Summary Identifying policies to reduce fetal exposure to alcohol during pregnancy is a high public health priority. More than 85% of US states have pregnancy-specific alcoh...
lluminating the biochemistry of zinc and RNA in live cells
Project Summary Zinc (Zn2+) is the second most abundant transition metal in mammals after iron. There are over two thousand proteins encoded by the human genome that contain zinc b...
Synthesis and Chemical Biology of Bioactive Natural Products
Project Summary/Abstract This proposal describes our program focused on the development of novel chemical reactions for complex molecule synthesis, innovative strategies for molecu...
Develop pan-specific antibody against mutant glycyl-tRNA synthetase for treating CMT2D
Abstract Charcot-Marie-Tooth (CMT) disease type 2D is caused by dominant mutations in GARS, encoding glycyl-tRNA synthetase (GlyRS). CMT is a clinically and genetically heterogeneo...
Innovation Corps Administrative Supplement for Magnetic Bronchoscope for Improved Pulmonary Access
One of every 16 Americans will be diagnosed with lung cancer in their lifetime. Each year in the United States there are nearly 250,000 new diagnoses and 150,000 deaths with an est...
New Statistical Methods for Modelling Cancer Outcomes
PROJECT SUMMARY/ABSTRACT Lung cancer is one of the most common causes of mortality worldwide. Radiomic features have been shown to provide prognostic values in predicting lung canc...
Molecular mechanisms of excitatory postsynaptic diversity
Unique patterns of synaptic connectivity between neurons, and the differential strength of those synapses, are fundamental to the information processing capability of the brain. Sy...
Novel Immunoregulatory Therapeutics for Systemic Lupus Erythematosus
Novel Immunoregulatory Drugs for Systemic Lupus Erythematosus BioTherapeutics, Inc (BTI) is an emerging biotech company that synergistically combines the power of advanced computat...
Regulating transcription of the key neural lineage driver ASCL1
The bHLH transcription factor ASCL1 (HASH1/MASH1) is essential for neuronal differentiation and sub-type specification of multiple neuronal cell-types throughout the brain, spinal...
Exploring cyclic di-nucleotide signaling across the tree of life
Scope of Work This administrative supplement will support Dr. Nkrumah Grant for a postdoctoral position in the Waters laboratory at Michigan State University. Dr. Grant will perfor...
Optimizing Colorectal Cancer Screening among Patients with Diabetes in Safety-Net Primary Care Settings: Targeting Implementation Approaches
ABSTRACT Patients with diabetes mellitus have an estimated 27% elevated risk of developing colorectal cancer (CRC) and are disproportionately Non-Hispanic blacks (NHBs) and Hispani...
Eradication of Escaped Variant Tumor Cells for Cancer Immunotherapy
Project Summary Recently, we discovered that adoptive transfer of CD39KO tumor-specific (mixed CD4+ and CD8+) T cells, resulted in long-term survival of mice bearing large establis...
Structural Biology of Dopamine Signaling
Abstract Human dopamine signaling pathway induces and facilitates dopamine neurotransmission through the mesolimbic dopaminergic pathway, which modifies reward-related behaviors an...
Identifying primary targets of bumped kinase inhibitor derived compounds to improve utility as therapy for castration resistant prostate cancer
Project Summary/Abstract Castration-resistant prostate cancer (CRPC) that inevitably escapes primary therapies most often retains dependency on androgen receptor (AR).We are reposi...
Electrocatalysis for the synthesis of chiral and PET imaging pharmaceuticals
Project Summary/Abstract Chiral drugs and radiolabelled compounds are two general classes of highly sought molecules for the detection, treatment, and prevention of disease. Chiral...
Neurally targeted group intervention to reduce early childhood anxiety
Clinically significant anxiety affects 20% of preschoolers and can become chronic, leading to depression, substance abuse, school-drop out and even suicide. To reduce anxiety and p...
Tulane StARR Program
Program Summary This is a new application for the Tulane StARR Program with a long-term goal to increase the number and diversity of highly trained, independent, interdisciplinary...
Harnessing acid-sensing ion channel toxins for therapeutic purposes
PROJECT SUMMARY/ABSTRACT Generalized anxiety and panic disorder are debilitating disorders resulting in severe social and economic impact for patients.Antidepressants and benzodiaz...
2/3 Genomics of Schizophrenia in the South African Xhosa
PROJECT DESCRIPTION The goal of this international collaborative project, in response to PAR-20-027, is to characterize the genetic architecture of schizophrenia in the Xhosa popul...