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201,169 grants found
Showing 199,101 – 199,120 of 201,169 grants
Predicting and Preventing Ventilator-Induced Lung Injury
Project Summary Acute respiratory distress syndrome (ARDS) is a rapid onset respiratory failure that is caused by factors ranging from pneumonia to sepsis.The impact of ARDS is sub...
The novel role of microtubule regulators in the DNA damage response
DNA damage, particularly DNA double strand break (DSB), has detrimental effects on cell survival and genomic stability.In response to DNA damage, the cell activates several evoluti...
Computational- and experimental- driven discovery of splicing regulation and circRNA function
Project Summary/Abstract Cells and organisms, from simple to complex, carry the same genetic DNA sequence organized into genes. Multicellular eukaryotes transcribe and process gene...
Structural Biology of Dopamine Signaling
Abstract Human dopamine signaling pathway induces and facilitates dopamine neurotransmission through the mesolimbic dopaminergic pathway, which modifies reward-related behaviors an...
The Role of the Microbiome and Notch Signaling in Esophageal Adenocarcinoma
PROJECT SUMMARY The incidence of esophageal adenocarcinoma (EAC) has risen 10-fold over the past half century and continues to have a dismal prognosis.Known modifiable risk factors...
Interplay between AMPK and Hippo Signaling Regulates Ocular Antiviral Response to Zika virus infection
PROJECT SUMMARY: Zika virus (ZIKV) is a teratogenic human pathogen that causes congenital eye and brain diseases.Affected babies exhibit vision impairment and associated ocular pat...
Epigenomics of asthma risk factors and clinical subtypes in minority children
PROJECT SUMMARY Asthma is the most common chronic disorder of children, with an estimated 300 million cases worldwide and with significant increases in incidence since the early 19...
Development of biophysical approaches to investigate high-resolution structure and dynamics of membrane proteins
Abstract Functional reconstitution of membrane proteins has been the major roadblock for the application of NMR and other biophysical techniques to investigate their high-resolutio...
Dynamics, Regulation and Function of p53 in Single Cells
The dynamics of signaling systems are critical for controlling gene expression programs and cellular outcomes.The tumor suppressor protein p53 is a transcription factor orchestrati...
Soft drusen in rhesus macaques as a nonhuman primate model of early age-related macular degeneration
PROJECT SUMMARY Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly, but current treatments target advanced stages when interventions may be l...
Gene regulatory networks for heart development
PROJECT SUMMARY Congenital heart defects (CHDs) are the most prevalent and serious birth defects, occurring in over 1% of live births.Major subsets of congenital heart defects are...
Strategic Molecular Activations for the Selective Synthesis of 2-Deoxy-Beta-Glycosides, and for the Synthesis of Novel Donor-Acceptor Stenhouse Adducts
Project Summary/Abstract This proposal describes the use of fundamental chemical properties to alter the reactivity of reagents for the synthesis of biomedically important compound...
Exploring cyclic di-nucleotide signaling across the tree of life
Summary: Exploring cyclic di-nucleotide signaling across the tree of life All organisms utilize molecular regulatory mechanisms connecting external sensory systems to phenotypic ou...
Community Action to Promote Healthy Environments
PROJECT SUMMARY The overarching goals of the Community Action to Promote Healthy Environments (CAPHE) partnership, established in 2014, are to: (1) develop new knowledge on local c...
Highly Selective Catalytic Reactions of Alkenes and Alkynes Relevant to Medicinal and Process Chemistry
Project Summary/Abstract A recent critical analysis of biologically active molecules and reactions most often used for their preparation suggests that fraction of saturated carbons...
Role of mitophagy in age-related respiratory and vascular diseases
PROJECT SUMMARY/ABSTRACT The overarching theme of my research program is to understand how innate immunity enhances age- associated cardiovascular and pulmonary diseases. As a phys...
Mentoring Patient-Oriented Research to Promote ARDS Precision Medicine
Acute respiratory distress syndrome (ARDS) afflicts up to 25% of mechanically ventilated patients admitted to an intensive care unit, carries a mortality that exceeds 30%, and has...
Deciphering principles of network dynamics underlying depression symptom severity from multi-day intracranial recordings in patients with major depression
PROJECT SUMMARY/ABSTRACT Major depressive disorder (MDD) is common and causes significant disability world-wide. While typically responsive to medications and therapy, there remain...
Evolution of Cargo Transport
Transporting cellular cargo with spatial and temporal precision is critical for many processes in all cells. Different cell types and organisms use diverse machineries for long-dis...
Novel Statistical Methods for Multi-omics Data Integration in Alzheimer's Disease
Novel Statistical Methods for Multi-omics Data Integration in Alzheimer's Disease Principal Investigators: Chong Wu, Ph.D. (contact); Jonathan Bradley, Ph.D.Summary A fundamen...