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201,169 grants found
Showing 199,121 – 199,140 of 201,169 grants
Developing novel CRISPR/CasX editors to generate a CCR5/null immune system
The characterization of CRISPR/Cas as a method to edit genes that contribute to human diseases provides new opportunities for the development of innovative therapeutic approaches....
Mechanisms regulating neural stem cell maintenance in the dentate gyrus
Project Summary Dr.Bond?s primary career goal is to run her own independent academic research group broadly investigating how principles of brain development can be used to underst...
Understanding Oral Anticoagulation Use and Success Among Patients with Psychiatric Multimorbidity in Atrial Fibrillation
Project Summary My long-term career goal is to become an independent pharmacist researcher with expertise in psychiatric multimorbidity research in cardiovascular disease.Through m...
WT1 as an oncogene and therapeutic target in anaplastic Wilms tumor
PROJECT SUMMARY/ABSTRACT Wilms tumor is the most common kidney cancer in children. High-risk patient groups continue to have dismal outcomes. The greatest predictor of a poor outco...
The Impact of Aging on Prostate Cancer with Age-Related Disruption of Th17/Treg Axis
Project Summary/Abstract: Prostate cancer (PCa) is particularly important in elderly men because of the high incidence and prevalence of disease and mortality in this group of pati...
Historic Violence and Contemporary Racial Disparities in Birth Outcomes
Abstract Racism and racist structures shape the social environment for all Americans, although the durable imprint of place on health and health disparities remains underexamined.R...
Alzheimer's Disease: New Trial Designs for Emerging Challenges
Project Summary/Abstract Alzheimer?s disease (AD) is characterized by heterogeneity in sex, race, APOE ?4 status, and tau. APOE ?4 status has been used to stratify AD patients in c...
Employing functionalized fragment libraries to identify therapeutic agents for neurofibromatosis type 2
Neurofibromatosis type 2 (NF2) is a dominantly inherited autosomal disease with the most common manifestation being development of bilateral schwannomas of the 8th cranial nerve (V...
Ligand discovery for delineating cholesterol homeostasis in the brain
Alzheimer?s disease (AD) is a long-term neurodegenerative disorder that ranks sixth in the leading cause of all deaths in the United States and features amyloid ? protein depositio...
Using Genetic Diversity to Manage Neurological Disease
Project Summary/Abstract Understanding and treating genome abnormalities that lead to rare genetic neurodegenerative diseases such as Niemann-Pick C1 globally managing cholesterol...
Glycosylation Analysis by Sheath-Flow SERS
Project Abstract Protein glycosylation plays important roles in various human diseases, including cancer, inflammatory, and neurodegenerative diseases. Glycoproteins, therefore, ar...
Inside-out construction of the biliary system
Project Summary The intrahepatic biliary tree functions to drain bile from hepatocytic canaliculi away from the liver.Congenital or acquired abnormalities in the formation and pate...
SARM1 functional polymorphisms and their contribution to ALS risk
Motor axon loss is a cardinal symptom of amyotrophic lateral sclerosis (ALS).Axon loss can be driven by a genetically encoded program in which the axon survival factors NMNAT2 and...
Leveraging Mechanical Control of Relaxation to Improve Diastolic Function
7.PROJECT SUMMARY/ABSTRACT Impaired diastolic relaxation, an important component of diastolic dysfunction, is present in nearly all patients with heart failure-both with reduced an...
Understanding the mechanisms underlying R-loop biogenesis and resolution in mammals
Project summary During transcription, the nascent RNA can anneal with the template DNA strand behind the advancing RNA polymerase and cause the formation of alternative DNA structu...
Identifying mechanisms that detect and eliminate aneuploid cells
Age-related macular degeneration, glaucoma and cataract are major causes of vision loss and all three diseases are age-related.Each is associated with the accumulation of senescent...
Repurposing an FDA approved Drug, B-Raf Kinase Inhibitor Dabrafenib for Protection from Cisplatin- and Noise- induced Hearing Loss
Abstract Hearing loss caused by noise, aging and chemotherapy affects seven hundred million people worldwide, but there are no FDA-approved drugs to prevent it.This research will t...
Pericytes differentiate into smooth muscle cells through HIF2a/SDF1 activation
ABSTRACT Pulmonary arterial hypertension (PAH) is a life-threatening disorder characterized by elevated lung pressures, right heart failure, and premature death.Current therapies f...
Develop pan-specific antibody against mutant glycyl-tRNA synthetase for treating CMT2D
Abstract Charcot-Marie-Tooth (CMT) disease type 2D is caused by dominant mutations in GARS, encoding glycyl-tRNA synthetase (GlyRS).CMT is a clinically and genetically heterogeneou...
TempO-Seq assay and cell panel for assessing impact of genetic diversity on compound bioactivity and toxicity risk
Summary: This Phase I project will demonstrate the feasibility for assessing the impact of genetic diversity on exposure and inferences to the corresponding risk of toxicity across...