Browse All Grants
201,169 grants found
Showing 199,201 – 199,220 of 201,169 grants
Mechanisms of RNA polymerase II transcription regulation
SUMMARY/ABSTRACT Our research program combines detailed biochemical reconstitution experiments with powerful cell-based assays, with a goal of gaining fundamental mechanistic insig...
Genetic and molecular correlates of white matter pathology in Alzheimers disease
PROJECT SUMMARY: Although Alzheimer's disease (AD) is typically defined by the accumulation of beta- amyloid and hyperphosphorylated tau proteins, synaptic loss and neuronal d...
Genetic determinants of thoracic aortic stiffness and remodeling
Project Summary / Abstract This is an application for a K24 mentoring award for patient-oriented research (POR) from Julio Chirinos, MD, PhD, Associate Professor of Medicine at the...
Hydrogen peroxide in endothelial function and dysfunction
The proposed studies will use new biosensors and novel chemogenetic approaches to identify the molecular mechanisms whereby reactive oxygen species (ROS) regulate nitric oxide (NO)...
Digital Phenotyping To Screen For Early Childhood Internalizing Disorders
ABSTRACT Childhood anxiety and depression are common, impairing, and have the potential to disrupt development well into adulthood. Pediatricians need mental health screening tools...
Receptor-mediated glucose sensing and skeletal muscle function
PROJECT SUMMARY Skeletal muscle is central to the development of metabolic dysfunction during type 2 diabetes (T2D) and obesity. In addition, these conditions are often accompanied...
Improving the science of adherence reinforcement and safe mobility in people with diabetic foot ulcers using smart offloading
PROJECT SUMMARY/ABSTRACT We aim to reduce the limb-threatening and life-limiting burden of neuropathic diabetic foot ulcers (DFU) by advancing science in its most critical componen...
Molecular Mechanisms of Arrestin-Domain Containing Proteins in Metabolism
The arrestin superfamily is composed of two subfamilies: the classical visual/beta-arrestins that were first identified as regulators of G-protein coupled receptor signaling, and t...
Telomerase-Mediated Healing of Double-Strand Breaks in Human Cells
PROJECT SUMMARY/ABSTRACT Telomeres—which define and protect the ends of humans’ linear chromosomes—serve as a natural check on carcinogenesis. Genome stability requires cells to di...
Synaptic transmission at retinal ribbon synapses
In sensory cells of the eye and inner ear the neurotransmitter glutamate is released at active zones in a graded and continuous manner. These cells have evolved specialized structu...
Light regulated vascular development in the eye via the Hippo pathway
Light regulated vascular development in the eye via the Hippo pathway Our recent studies show that opsin-mediated light responses function as developmental timing cues for vascular...
A Human-Mimetic AI System for Automatic, Passive and Objective Dietary Assessment
A Human-Mimetic AI System for Automatic, Passive and Objective Dietary Assessment Unhealthy diet is strongly linked to risks of chronic diseases, such as cardiovascular diseases, d...
Ion permeation, lipid flipping, and membrane remodeling by TMEM16 proteins
Project Summary/Abstract Calcium activated Chloride Channels (CaCCs) and other TMEM16 family members form ion channels and/or lipid scramblases that help orchestrate a large number...
Inside-out construction of the biliary system
Project Summary The intrahepatic biliary tree functions to drain bile from hepatocytic canaliculi away from the liver. Congenital or acquired abnormalities in the formation and pat...
Epigenetic dysregulation in diabetic enteric neuropathy
Diabetic gastroenteropathy includes asymptomatic delayed gastric emptying, dyspepsia with or without mildly delayed gastric emptying, or gastroparesis, which is characterized by mo...
Mechanism and dynamics of islet GABA signaling
Gamma-aminobutyric acid (GABA) is a potent neurotransmitter produced in the islet at levels as high as in the brain.While the function of GABA in the nervous system is well-underst...
Preparing College Students who Enter from High School or Transfer from Community Colleges for STEM Careers and Graduate School
This project will contribute to the national need for well-educated scientists, mathematicians, engineers, and technicians by supporting the retention and graduation of high-achiev...
Collaborative Research: MTM 2: Using successional dynamics, biogeography, and experimental communities to examine mechanisms of plant-microbiome functional interactions
Microbial communities (microbiomes) play important roles in animals, plants, and even whole ecosystems. However, microbiomes are constantly changing through time and space. These c...
PFI-TT: Electrodeposited Flexible Superconducting Cables for Quantum Applications
The broader impact / commercial potential of this Partnerships for Innovation – Technology Translation (PFI-TT) project is to enable automated assembly and scaled manufacturing of...
CHS: Small: DeepCrowd: A Crowd-assisted Deep Learning-based Disaster Scene Assessment System with Active Human-AI Interactions
Recent advances in artificial intelligence (AI) have transformed many important domains of modern life such as transportation, finance, education, healthcare, and entertainment. Th...