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201,169 grants found
Showing 199,441 – 199,460 of 201,169 grants
CCL2 and CCR2 as metastatic drivers and therapeutic targets in medulloblastoma
PROJECT SUMMARY Brain tumors are the most common solid tumor and the leading cause of cancer-related death in children. Medulloblastoma (MB) is the most common malignant pediatric...
How do CNS fibroblasts regulate the response to neuroinflammation?
ABSTRACT Fibrosis, defined by the deposition of collagen I, is a devastating pathological event that occurs in many organs including the heart, kidney, liver and lung in response t...
Impact of brain estrogens on cognition and brain aging in a non-human primate
SUMMARY Aromatase inhibitors (AIs) are drugs that inhibit estrogen synthesis and that are prescribed to prevent the recurrence of estrogen responsive breast cancers. However, AIs,...
The role and regulation of p53 in obesity-induced liver cancer
Project Summary/Abstract Obesity is a prevalent global health problem, and it increases the overall risks of many types of chronic diseases and cancers. Nonalcoholic steatohepatiti...
Transcriptional control of retinal neuron specification and maturation.
PROJECT SUMMARY/ABSTRACT Amacrine cells (ACs) are the principle inhibitory neurons of the inner retina, with at least 45 morphologically distinct subtypes that can be distinguished...
Dynamics of calcium signals control neurotransmitter release in retinal ribbon synapses
Retinal bipolar cells are the first 'projection neurons' of the vertebrate visual system and transmit all of the information needed for vision. Bipolar cells can signal c...
Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermia
Project Summary/Abstract Proper temperature and oxygen levels enable essential life activities. Low temperature (hypothermia) and reduced level of oxygen (hypoxia) pervasively infl...
Highly Selective Catalytic Reactions of Alkenes and Alkynes Relevant to Medicinal and Process Chemistry
Project Summary/Abstract Discovery of fundamentally new catalytic reactions, especially enantioselective ones, showing high turnover frequencies (i.e., substrate/ catalyst/unit tim...
Action of Lipolytic Enzymes
PROJECT SUMMARY/ABSTRACT The overall goal of this grant in recent years has been to describe in molecular detail the mechanism of action of physiologically important human forms of...
TAK1 Signaling Pathways
Abstract Innate immune signaling pathways are activated in response to exposure to microorganisms, and generally are effective in preventing pathogen invasion through inducing infl...
hiPS cells derived skeletal muscle progenitors and their extracellular vesicles for treatment of sarcopenia
PROJECT SUMMARY Aging of skeletal muscle results in sarcopenia. It is believed that sarcopenia is in part due to a decreased capacity of stem cells, namely satellite cells, to repa...
Elucidating the molecular mechanisms underlying ligand-dependent REV-ERB activity in Th17 cells
Project Summary/Abstract Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis are characterized by an inappropriate immune response to commensal gut...
Synthesis and Chemical Biology of Bioactive Natural Products
Project Summary/Abstract This proposal describes our program focused on the development of novel chemical reactions for complex molecule synthesis, innovative strategies for molecu...
PedGeneRx - Admin Supplement to Base Editing and Prime Editing for Sickle Cell Disease R01
ABSTRACT: There is a substantial unmet need for the development of new treatments for patients with monogenic disorders such as sickle cell disease (SCD) and gene therapy technolog...
Mechanism of Chromatin Accessibility, 3D Chromosome Organization, and Their Functions in Gene Regulation
Project Summary One of the major focus of the parental grant, R35 GM139654, is to study the mechanism and function of pioneer factors (PFs). Pioneer factors (PFs) can invade nucleo...
Lamba_Admin_Supp_Re_Entry_Mar2022
PROJECT SUMMARY Leber congenital amaurosis (LCA) is a group of devastating early-onset retinal dystrophies affecting roughly 1/50,000 to 1/33,000 newborns. LCA-associated variants...
Translating Hyperpolarized 13C Metabolic MRI to Predict Renal Tumor Aggressiveness
Project summary: This project aims to clinically translate hyperpolarized (HP) 13C pyruvate MRI as an innovative metabolic imaging approach for noninvasive prediction of renal tumo...
Chemotherapy-driven evolution of the vascular secretome and its role in therapeutic resistance
PROJECT SUMMARY Our continued inability to develop selective therapies that prevent the emergence of disseminated breast tumor cells into lethal metastases necessitates new approac...
Ligand discovery for delineating cholesterol homeostasis in the brain
Alzheimer’s disease (AD) is a long-term neurodegenerative disorder that ranks sixth in the leading cause of all deaths in the United States and features amyloid β protein depositio...
An easy-to-use software for 3D behavioral tracking from multi-view cameras
Project Summary The overarching goal of this administrative supplement is to increase the adoption and utilization an exciting new technology for 3D pose tracking, DANNCE, that we...