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201,169 grants found
Showing 199,481 – 199,500 of 201,169 grants
Pericytes differentiate into smooth muscle cells through HIF2a/SDF1 activation
ABSTRACT Pulmonary arterial hypertension (PAH) is a life-threatening disorder characterized by elevated lung pressures, right heart failure, and premature death. Current therapies...
Extracellular Vesicle Analyses to Develop Aging and Resilience Biomarkers
Abstract Extracellular vesicles (EVs) are membranous particles released from nearly all cell types into all bodily fluids evaluated to date — including serum and plasma. Depending...
Investigating the Associations Between Safety Cue Learning and Trauma Exposure in Development
Exposure to trauma throughout the lifespan, and in particular during childhood and adolescence, is prevalent, with more than two-thirds of all children in the United States having...
Developmental Regulation of Gene Expression by Long Undecoded Transcript Isoforms
PROJECT SUMMARY Dynamic gene expression programs drive essential biological processes including cellular differentiation and stress response pathways. During these processes, cells...
Behavioral and neural properties of spatial direction comprehension in aging and amestic mild cognitive impairment
Project Summary: Spatial navigation is an essential task for living a safe, independent life. Spatial navigation skills decline in normal aging and become progressively impaired in...
Human Factors of Aging Program
Abstract:The candidate, Mark S Redfern, PhD, is a professor at the University of Pittsburgh with a primary appointment in the Department of Bioengineering, Swanson School of Engine...
cryoEM Studies of Muscle
Project Summary The long term goal of this research project has been and continues to be an understanding of the molecular mechanism of muscle function. The existing project, funde...
The identification and pathophysiology of non-infarcted but injured myocardium in the post-ischemic heart
ABSTRACT - In the post-ischemic heart, relatively little is known about the injured-but-not-infarcted myocardium, which we call the intermediate zone as it is neither normal nor in...
Identification of novel phosphodiesterase (PDE)-modulating compounds and characterization of associated cytoprotective pathways in lightdamagedretina
PROJECT SUMMARY Cyclic nucleotide phosphodiesterases (PDEs) are a class of enzymes ubiquitously expressed in the human body, and they play a critical role in a broad range of physi...
Developing computational algorithms for histopathological image analysis
Project Summary Histopathology is the cornerstone of disease diagnosis and prognosis. With the advance of imaging technology, whole-slide image (WSI) scanning of tissue slides is b...
WT1 as an oncogene and therapeutic target in anaplastic Wilms tumor
PROJECT SUMMARY/ABSTRACT Wilms tumor is the most common kidney cancer in children. High-risk patient groups continue to have dismal outcomes. The greatest predictor of a poor outco...
Cholangiocyte-Derived Endothelin Signaling Mediates Biliary Injury and Liver Fibrosis
The main goal of this application is to clarify the signaling mechanisms mediating biliary senescence and angiogenesis during primary sclerosing cholangitis (PSC). It is known that...
Pharmacological Npt2a inhibition as a treatment for hyperphosphatemia in chronic kidney disease
The precise regulation of the body's phosphate homeostasis is a critical task. Treatment of hyperphosphatemia, which becomes inevitable in later stages of chronic kidney disea...
Phase 2 Study of Theophylline for the Treatment of Psuedohypoparathyroidism
Pseudohypoparathyroidism (PHP) is a rare, genetic disorder caused by impaired stimulatory G protein (Gsα) signaling through downregulation of the gene, GNAS.The resultant hormone a...
Transcriptional Control of Skeletal Muscle Atrophy
Skeletal muscle atrophy results from insufficient nutrition, aging, certain medications, and a wide range of medical illnesses including cancer, diabetes mellitus, heart or renal f...
Veterans Affairs - Translational Education and Mentoring (VA-TEAM) Center
Agencies that fund medical research are under increasing pressure to translate funded research projects to commercial entities. These commercial entities can obtain the necessary e...
Mechanism of Vascular Impairment in Neurocognitive Disorders
Vascular cognitive impairment and dementia (VCID) is the most common etiology of dementia in the elderly including veterans. Since proportion of the elderly population is progressi...
Small Molecule KLF15 Agonists for Kidney Disease
The Centers for Disease Control and Prevention estimates more than 15% of adults in the United States, over 30 million Americans have chronic kidney disease (CKD). Podocytes are ep...
Dynamics of protein kinase CK2 signaling in prostate cancer pathogenesis
Prostate cancer (PCa) is one of the major health issues for the aging Veterans population warranting investigations to further advance knowledge of the disease pathobiology and ben...
CMA: Network plasticity in acquired epileptogenesis
Temporal lobe epilepsy (TLE) is the most common form of epilepsy in adults and a major source of disability in the veteran population as it is frequently caused by war-time head in...