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201,169 grants found
Showing 199,501 – 199,520 of 201,169 grants
Preoptic/Hypothalamic Mechanisms of Sleep-Wake Regulation
ABSTRACT Chronic sleep disturbance is a frequent and challenging problem of human aging. In the US an estimated 39.6 million people including 8.5 million Veterans are aged 65 or ol...
A role and regulation of glucose responsive lipolysis in pancreatic beta cells
T2D is a major health problem for US veterans that imposes significant physical, financial, and emotional tolls. Thus, there is a strong and urgent need for an effective and widely...
Toxicant Exposure Impacts Host-pathogen interactions within the Reproductive Tract
Project Summary Exposure to persistent environmental toxicants (such as dioxin) is a global problem, but disproportionately affects Veterans who were exposed dioxin derived from bu...
CMA: Network plasticity in acquired epileptogenesis
Project Summary/ Abstract: Temporal Lobe Epilepsy (TLE) is the most frequent type of post-traumatic epilepsy, causing significant morbidity in the veteran population. Approximatel...
Traumatic Brain Injury and Vascular Disease
Objective: Traumatic brain injury (TBI) is a common cause of morbidity and mortality in the veteran population. In the United States, there are an estimated 5.3 million people livi...
Defining Breath VOC Biomarkers to Improve Respiratory Health of Exposed Veterans
The goal of this resubmitted application is to define signature exhaled breath volatile organic compounds (VOCs) in veterans exposed to toxicants and to develop an effective portab...
Colon cancer nanotherapy targeting STRAP
Although activation of the Ras/Raf/MEK/ERK pathway is involved in cell growth, inhibition of apoptosis, induction in stem-like phenotype, and drug resistance, little is known about...
Developing novel CRISPR/CasX editors to generate a CCR5/null immune system
The characterization of CRISPR/Cas as a method to edit genes that contribute to human diseases provides new opportunities for the development of innovative therapeutic approaches....
Host factors affecting susceptibility to Candida auris.
This VA Merit research project aims to define host factors associated with mucosal infection by an emerging multi-drug resistant human fungal pathogen, Candida auris. Most human fu...
Foxp transcription factors in regulatory T cells
Regulatory T cells (Tregs) are critical for actively maintaining immune tolerance. The Foxp family of transcription factors is composed of four members; Foxp1, Foxp3 and Foxp4 are...
Beta1-selective blockade for prevention of postmenopausal bone loss: A randomized controlled trial
Osteoporosis is a disease of aging that leads to ~2 million fractures and ~$17 billion in healthcare costs annually. Although several drugs are FDA-approved for the treatment of os...
Molecular mechanisms of exocytotic vesicle fusion and release.
Fusion of membrane bound vesicles with a target membrane is of ubiquitous importance for cellular function from intracellular trafficking to exocytotic release of various mediators...
Neural Substrates of Binge Drinking
Alcohol misuse is responsible for ~88,000 deaths annually and exerts an annual cost of ~$250 billion in the US. Binge drinking, which accounts for ~75% of these costs, is defined b...
Pathologic Signaling Pathways in AML Cells
Abstract: Acute myeloid leukemia (AML) is a serious blood cancer that affects United States Veterans and other individuals. Multiple studies have demonstrated that active signaling...
Targeting the gut-brain axis to facilitate weight loss in high fat diet consumers
Current therapies for obesity treatment are effective at producing weight loss but weight loss maintenance remains a significant challenge (Franz et al., 2007; Sawamoto et al., 201...
mTOR-Mediated Desaturation of Fatty Acids in Hepatic Insulin Resistance.
Discharged members of the US Armed Services are at an increased risk of metabolic disease which is exemplified by the prevalence of type 2 diabetes mellitus (T2DM) affecting an est...
Establishing smoke-free homes with families involved in child protective services: An effectiveness-implementation trial of an integrated program
Project Abstract Child exposure to secondhand smoke (SHS) is linked to multiple forms of cancer throughout the lifespan. Young children living in low-socioeconomic status household...
Combining modeling and experiments to study the evolution of cells with altered ploidy
Project Summary Aneuploidy is a ubiquitous feature of cancer cells, and accumulation of aneuploidy is believed to often happen via tetraploidization (genome doubling) as an interme...
Modeling the dynamicimpact of rare and common genetic variation on gene expression anddisease
Understanding the genetic basis of human disease will require a deep understanding of genetic effects on gene expression. The vast majority of disease-risk loci are non-coding, so...
Allorecognition, parasitic stem cells and regeneration in a basal chordate
Abstract Our lab works at the intersection of immunology, stem cell biology and regeneration, and the grants funding this work (GM123267 and GM 123255) which we are requesting to m...