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201,169 grants found
Showing 199,521 – 199,540 of 201,169 grants
Developing nonmuscle myosin II inhibitors for the treatment of glioblastoma
PROJECT SUMMARY An area of significant unmet need is the treatment of glioblastoma (GBM), an aggressive, fast-growing and lethal brain cancer that represents 15% of all brain tumor...
Developmental underpinnings of substantia nigra vulnerability
Abstract: DA neuron degeneration, resulting in deficient DA signaling, underpins the debilitating motor symptoms of Parkinson’s disease (PD). Among DA neurons, those located in ven...
Defining the genetic landscape of nanophthalmos and the role of MYRF
Defining the genetic landscape of nanophthalmos and the role of MYRF ABSTRACT: Nanophthalmos is part of a spectrum of disorders characterized by a small eye and resultant high hype...
The role of type 1 dendritic cells in CD4 and CD8 T cell anti-tumor immunity
PROJECT SUMMARY Cancer immunotherapies have revolutionized the treatment of malignancies, but these therapeutics still face enormous challenges and limited efficacy in many patient...
Studies of the structural and functional basis of neuroblastoma drug resistance
PROJECT SUMMARY/ABSTRACT Neuroblastoma is the most common extracranial tumor of young children, and the five-year overall survival of children with high-risk disease is less than 5...
Fluid shear stress mechanotransduction at endothelial cell-cell junctions
Project Summary This project aims to understand in molecular detail how fluid shear stress acting on endothelial cells triggers mechanical activation of signaling pathways at cell-...
Determining the role of macrophages in the developing cardiac conduction system
PROJECT SUMMARY/ABSTRACT Macrophages are well-characterized as sentinel immune cells that coordinate cellular responses to injury and infection. However, emerging evidence demonstr...
Deep learning models to predict primitive streak formation in human development
Project Summary Congenital birth defects affect an estimated 3% of live births. To develop effective treatment strategies, a thorough understanding of early human development is ne...
Brachytherapy to achieve in situ cancer vaccination
Project Summary/Abstract We aim to improve the cure rates for metastatic cancers. To achieve this we propose a combined modality approach to stimulate and diversify an endogenous a...
Accelerating collaborative, cumulative, and open intervention science with an e-intervention authoring platform
Background. Research has identified a wide range of evidence-based interventions for key behavioral health risks such as poor diet, smoking, unhealthy alcohol use, or a sedentary l...
Telomerase-Mediated Healing of Double-Strand Breaks in Human Cells
PROJECT SUMMARY/ABSTRACT Telomeres—which define and protect the ends of humans’ linear chromosomes—serve as a natural check on carcinogenesis. Genome stability requires cells to di...
RNA Nanosystem for Posterior Eye Drug Delivery
RNA nanotechnology provides molecules that have the simplicity in design with the characteristics of DNA and can be used in therapies. However, a major problem in RNA nanotechnolog...
DNA-based Immune Phenotyping in HNSCC for Biomarkers of Response to Immunotherapy
PROJECT SUMMARY/ABSTRACT Head and Neck Squamous Cell Carcinomas (HNSCCs) are devastating upper airway tumors that are associated with an immunosuppressive network impacting the tum...
Regulation of Development by LRP4 at Drosophila Peripheral Synapses
Project Summary The nervous system is a vastly complex network which develops through intricate and tightly regulated processes. One critical aspect of neurodevelopment is the form...
Gene regulatory networks for heart development
PROJECT SUMMARY Congenital heart defects (CHDs) are the most prevalent and serious birth defects, occurring in over 1% of live births. Major subsets of congenital heart defects are...
Computational- and experimental- driven discovery of splicing regulation and circRNA function
Project Summary/Abstract Cells and organisms, from simple to complex, carry the same genetic DNA sequence organized into genes. Multicellular eukaryotes transcribe and process gene...
Iowa StARR Scholars Program
PROJECT SUMMARY The Iowa StARR Scholars Program is designed to help address the continuing need for physician-scientists in the fields of internal medicine and pediatrics. The Univ...
Investigating cognitive-motor variability to predict driving performance in stroke survivors with MCI
PROJECT SUMMARY/ABSTRACT Dr. Neha Lodha is an Assistant Professor in the Department of Health and Exercise Science at Colorado State University (CSU). Dr. Lodha's long-term ca...
Strategic Molecular Activations for the Selective Synthesis of 2-Deoxy-Beta-Glycosides, and for the Synthesis of Novel Donor-Acceptor Stenhouse Adducts
Project Summary/Abstract This proposal describes the use of fundamental chemical properties to alter the reactivity of reagents for the synthesis of biomedically important compound...
Modeling Immune Cell Recruitment and its Impact on Triple Negative Breast Cancer Recurrence in the Irradiated Microenvironment
PROJECT SUMMARY Approximately half of triple negative breast cancer (TNBC) patients receive breast conserving therapy, which includes irradiating the primary tumor site. Although t...