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201,169 grants found
Showing 199,561 – 199,580 of 201,169 grants
Novel Immunoregulatory Therapeutics for Systemic Lupus Erythematosus
Novel Immunoregulatory Drugs for Systemic Lupus Erythematosus BioTherapeutics, Inc (BTI) is an emerging biotech company that synergistically combines the power of advanced computat...
Extrinsic regulation of primitive, myeloid-biased hematopoietic stem cells by Semaphorin 4a
ABSTRACT Despite substantial experimental evidence for the important functional role of myeloid-biased HSC (myHSC) in stress, inflammation and aging, the mechanisms which control m...
A Precision Medicine Approach To Study Targetable Pathways in Vascular Dementia
Dr. Elahi is an early career physician-scientist with specialty training in neurodegenerative disease and experience in biomarker development, who seeks to develop her career at th...
Assessment of EEG Responses to Spinal Cord Stimulation Waveforms in Chronic Pain Patients
Chronic pain is a significant problem and it has been estimated to affect about 50 million adult Americans.It accounts for more than 600 billion dollars in health care expenditures...
hiPS cells derived skeletal muscle progenitors and their extracellular vesicles for treatment of sarcopenia
PROJECT SUMMARY Aging of skeletal muscle results in sarcopenia. It is believed that sarcopenia is in part due to a decreased capacity of stem cells, namely satellite cells, to repa...
X-ray/optical tomographic guidance and assessment for pre-clinical radiation Research
PROJECT SUMMARY/ABSTRACT Over the past 10-years, our group has made multi-disciplinary efforts to bridge the technological gap between radiation methods for human treatment and pre...
Delineating epigenetic coordination of regenerative cell plasticity
Delineating epigenetic coordination of regenerative tissue plasticity Abstract: Tissue damage and repair represent fundamental problems in human health for which few pharmacologica...
Novel therapeutic approach for severe ARDS with a potent pharmacologic allosteric hemoglobin modifier
Acute respiratory distress syndrome (ARDS) is a life-threatening condition featuring acute onset of non- cardiogenic respiratory failure and hypoxemia. Consequently, patients with...
Rapid identification and selection of functional antigen-specific monoclonalantibodies by FcGR-enabled screening on CellRaft Arrays in the CellRaft AIRSystem
Project Summary The production of antibodies using hybridoma or primary B-cells with in vitro screening technologies represents one of the most industrialized processes in contempo...
The neural foundations of regulation in infancy and the role of individual and environmental factors over time
Project Summary/Abstract The neural mechanisms of regulation support socioemotional competence 63,74 and may operate as resilience factors in the face of developmental risk for psy...
Employing functionalized fragment libraries to identify therapeutic agents for neurofibromatosis type 2
Neurofibromatosis type 2 (NF2) is a dominantly inherited autosomal disease with the most common manifestation being development of bilateral schwannomas of the 8th cranial nerve (V...
Using Genetic Diversity to Manage Neurological Disease
Project Summary/Abstract: This one-year Administrative Supplement request in response to NOT-AG-22-025/PA-20-272 is a proposal to use our state-of-the-art Gaussian Process (GP) mac...
Retinal Mitochondrial Metabolism in Alzheimer's Disease
PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD) is the leading cause of dementia. Effective treatment and tests for early diagnosis are still not available. AD patients often hav...
Dynamics of calcium signals control neurotransmitter release in retinal ribbon synapses.
Project Abstract Dementias, including those associated with Alzheimer's disease (AD), are major neurodegenerative disorders that cause visual problems due to pathologic change...
Mitochondrial calcium overload and necrosis in tauopathies caused by inhibition of Mfn2 and NCLX
Abstract Tau aggregates (also known as neurofibrillary tangles or NFTs) are hallmarks of the neurodegenerative diseases collectively known as tauopathies. These diseases are a broa...
Exploring cyclic di-nucleotide signaling across the tree of life
Summary: Exploring cyclic di-nucleotide signaling across the tree of life All organisms utilize molecular regulatory mechanisms connecting external sensory systems to phenotypic ou...
Optimizing sleep spindle measurements as translational assays of memory consolidation
This research proposal addresses a key challenge to drug development: the paucity of biomarkers that reveal whether interventions affect implicated brain circuitry at early stages,...
Mechanistic analysis and allellic genome editing of iPSC-derived dominant LCA model
PROJECT SUMMARY Leber congenital amaurosis (LCA) is a group of devastating early-onset retinal dystrophies affecting roughly 1/50,000 to 1/33,000 newborns. LCA-associated variants...
Synthesis and Characterization of Nitrogen and Sulfur Donor-Acceptor Stenhouse Adducts
Project Summary/Abstract This proposal describes the use of fundamental chemical properties to alter the reactivity of reagents for the synthesis of biomedically important compound...
Understanding the mechanisms underlying R-loop biogenesis and resolution in mammals
Project summary During transcription, the nascent RNA can anneal with the template DNA strand behind the advancing RNA polymerase and cause the formation of alternative DNA structu...