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201,169 grants found
Showing 199,621 – 199,640 of 201,169 grants
lluminating the biochemistry of zinc and RNA in live cells
Project Summary Zinc (Zn2+) is the second most abundant transition metal in mammals after iron. There are over two thousand proteins encoded by the human genome that contain zinc b...
Genome-wide structure-based analysis of protein-protein interactions and networks
Project Summary Our lab works in the general area of computational structural biology although it also includes an experimental component. We carry out theoretical and computationa...
The functions of the zinc finger protein ZPR1 in R-loop metabolism and neurodegeneration.
PROJECT SUMMARY The goal of this study is to examine the functions of the zinc finger protein ZPR1 in R-loops metabolism and neurodegeneration. R-loops are formed during transcript...
The Ancestral Populations Network Phenotypic Harmonization Working Group Administrative Supplement: 2/3 Genomics of Schizophrenia in the South African Xhosa
PROJECT SUMMARY This project actualizes a primary goal of the Ancestral Populations Network (APN; PAR-20-026 and PAR-20- 027), namely to facilitate measurement and data analytic ha...
EPPIC-Net Pain Research - Application for Clinical Trial and Related Activities (OT2)
This OT Award funds clinical trials within The Early Phase Pain Investigation Clinical Network (EPPIC-Net). EPPIC-NET is part of the NIH Helping to End Addiction Long-term (HEAL) I...
Mitigating sexual stigma within healthcare interactions to improve engagement of MSM in HIV prevention
Long-term objective. My long-term objective is to explore, identify and evaluate acceptable, feasible and appropriate techniques and mechanisms to mitigate HIV-related stigma in he...
Lamba Admin Supp cryo-storage
PROJECT SUMMARY Leber congenital amaurosis (LCA) is a group of devastating early-onset retinal dystrophies affecting roughly 1/50,000 to 1/33,000 newborns. LCA-associated variants...
Dissecting the mechanistic role of multinucleation in breast and trophoblast cancers
Project Summary/Abstract A key driver of cancer is the global deregulation of transcription networks in the cell. Transcriptional output is dependent on chromatin structure and top...
Investigating cognitive-motor variability to predict driving performance in stroke survivors with MCI
PROJECT SUMMARY/ABSTRACT Dr. Neha Lodha is an Assistant Professor in the Department of Health and Exercise Science at Colorado State University (CSU). Dr. Lodha's long-term ca...
Dendritic Mechanisms Underlying Behaviorally-Relevant Activity in a Descending Auditory Pathway
Project Summary/Abstract Active listening is central to auditory cognition, supporting critical functions such as stream segregation, linguistic analysis and perceptual learning. T...
How do CNS fibroblasts regulate the response to neuroinflammation?
ABSTRACT Fibrosis, defined by the deposition of collagen I, is a devastating pathological event that occurs in many organs including the heart, kidney, liver and lung in response t...
Transcriptional control of retinal neuron specification and maturation.
PROJECT SUMMARY/ABSTRACT Amacrine cells (ACs) are the principle inhibitory neurons of the inner retina, with at least 45 morphologically distinct subtypes that can be distinguished...
Diagnosing and predicting risk in children with SARS-CoV-2- related illness
In the wake of COVID-19 pandemic, Multisystem Inflammatory Syndrome in Children (MIS-C) has evolved as a new threat to children exposed to SARS-CoV-2. The emergence of MIS-C is so...
A data science approach to identify and manage Multisystem Inflammatory Syndrome in Children (MIS-C) associated with SARS-CoV-2 infection and Kawasaki disease in pediatric patients
Summary – Since the SARS-CoV-2 pandemic began, the emergence of an associated novel multisystem inflammatory syndrome in children (MIS-C) has been reported. Interestingly, patients...
AICORE-kids: Artificial Intelligence COVID-19 Risk AssEssment for kids
This work is directed at characterizing pediatric COVID-19 and stratifying incoming patients by projected (future) disease severity. Such stratification has several implications: i...
Diagnosis of MIS-C in febrile children
PROJECT SUMMARY The recent emergence of SARS-CoV-2 and resultant pandemic of COVID-19 disease has overwhelmed global health systems and led to over 200,000 American deaths to date....
Severity Predictors Integrating salivary Transcriptomics and proteomics with Multi neural network Intelligence in SARS-CoV2 infection in Children (SPITS MISC)
Abstract Children have been disproportionately less impacted by the Corona Virus Disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Corona Virus 2 (SAR-CoV-2)...
Identifying biomarker signatures of prognostic value for Multisystem Inflammatory Syndrome in Children (MIS-C)
PROJECT SUMMARY / ABSTRACT In adults, SARS-CoV-2 infection exhibits a wide range of clinical outcomes, from asymptomatic and mild disease to severe viral pneumonia, respiratory dis...
Discovery and clinical validation of host biomarkers of disease severity and multi-system inflammatory syndrome in children (MIS-C) with Covid-19
ABSTRACT Novel approaches for early and accurate diagnosis of COVID-19 associated syndromes and evaluation of clinical severity and outcomes of COVID-19 disease in children are urg...
COVID-19 Network of Networks Expanding Clinical and Translational approaches to Predict Severe Illness in Children (CONNECT to Predict SIck Children)
The SARS-CoV-2 pandemic has manifested in children with a wide spectrum of clinical presentations ranging from asymptomatic infection to devastating acute respiratory symptoms, app...