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201,169 grants found
Showing 199,641 – 199,660 of 201,169 grants
Diagnosing and predicting risk in children with SARS-CoV-2- related illness
Multisystem Inflammatory Syndrome in Children (MIS-C) caused significant morbidity and mortality in children during the COVID-19 pandemic, but we know little about the molecular pa...
Neurodevelopment after postnatal Zika virus infection in infant macaques
PROJECT SUMMARY / ABSTRACT Intense research has focused on the neurologic effects of prenatal Zika virus (ZIKV) infection; however, the consequences of postnatal infection early in...
Experimental and computational analysis of mechanisms of mitochondrial-cellular ROS crosstalk in the kidney in salt-sensitive hypertension
PROJECT SUMMARY Salt-sensitive hypertension is a significant health problem worldwide and there is a need to understand the underlying molecular mechanisms to enable more effective...
Emotion Regulation Flexibility and Suicide Risk
PROJECT SUMMARY/ABSTRACT Suicide is the second leading cause of death for adolescents and young adults, with rates of suicide deaths rising in the past two decades. Research examin...
Mechanism of cardiovascular disease in premenopausal women
PROJECT SUMMARY Suboptimal nutrition is the leading risk factor for death and disability worldwide and accounts for accounts for more than 45% of cardiovascular death in the US. Di...
Experimental and modeling investigations into microcircuit, cellular and subcellular determinants of hippocampal ensemble recruitment to contextual representations
Although neuroscience has recently provided a great deal of information about how neurons represent and encode behaviorally relevant information at the population level, the fundam...
Targeting Pathologic Spike-Ripples to Isolate and Disrupt Epileptic Dynamics
Project Summary Epilepsy is the world’s most common, serious brain disorder, affecting nearly 50 million people worldwide. For one-third of patients, seizures remain poorly control...
Role of MIF and CD74 in the pathogenesis of emphysema
PROJECT SUMMARY Emphysema is a common pathologic manifestation of Chronic Obstructive Pulmonary Disease (COPD), the fourth leading cause of death in the United States. The most imp...
Leveraging implementation and behavioral science to reduce harmful overuse of diagnostic testing in critically ill children
Project Abstract Overtreatment – health care in which the benefit does not outweigh risks – accounts for up to $200 billion annually in the United States, and is associated with wo...
Spatial repellents to reduce the outdoor transmission of malaria
ABSTRACT Despite the recognized and urgent need for public health interventions that interrupt outdoor malaria transmission, no such proven interventions are available. Transfluthr...
Mechanisms and Modulation of Opsin 3 Mediated Airway Smooth Muscle Relaxation
Project Summary/ Abstract Light-mediated relaxation of smooth muscle has been recently demonstrated. Non-visual opsins expressed on smooth muscle have been implicated as the key me...
The isolated impacts of alcohol policies on birth outcomes
Project Summary Identifying policies to reduce fetal exposure to alcohol during pregnancy is a high public health priority. More than 85% of US states have pregnancy-specific alcoh...
Impact of alcohol exposure on unjamming the airway epithelium
PROJECT ABSTRACT Alcohol use disorder affects over 14 million adults and causes 88,000 deaths each year in the United States.Chronic alcohol use significantly increases people?s ri...
Visualizing and elucidating the FGF-dependent mechanisms of urethral morphogenesis
PROJECT SUMMARY Hypospadias is a birth defect wherein the urethral opening is displaced from the distal end of the penis and instead terminates on the ventral side of the penis, or...
Ultraviolet Photodissociation Mass Spectrometry for Characterization of Biological Molecules
Abstract. Understanding the functions of lipids, proteins and even larger macromolecular assemblies depends on deciphering complex structures of individual molecules as well as dec...
Managing Cardiac Toxicities of Cancer Therapy
Project Summary This R35 application proposes to capitalize on previous work produced by the PI over the past 11-years and to further serve as a strong foundation for interrogating...
Development of biophysical approaches to investigate high-resolution structure and dynamics of membrane proteins
Abstract Functional reconstitution of membrane proteins has been the major roadblock for the application of NMR and other biophysical techniques to investigate their high-resolutio...
Early Detection and Diagnosis of Lung Cancer with Endomicroscopy
PROJECT SUMMARY Early diagnosis of lung cancer is critical to patient survival. Unfortunately the vast majority of cases are detected once symptoms arise and the cancer has spread...
Effectiveness of an Empirically Supported Family Intervention: Mental Health Outcomes, Mechanisms of Effect, and Organizational Factors
Project Summary/Abstract Cost-effective, brief programs to support family communication and improve mental health in youth are a pressing need; yet few evidence-based programs exis...
Tracking the dynamics of how schemas scaffold recall
Project SummaryThe locations where our life experiences unfold are remarkably potent and enduring cues to memory. For instance, stepping back into a familiar café can reignite the...