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201,169 grants found
Showing 199,681 – 199,700 of 201,169 grants
Modeling myelodysplasia
PROJECT SUMMARY Myelodysplastic Syndromes (MDS) are a cancer of the hematopoietic stem cell (HSC) on the rise in the aging population and cancer survivors. The only curative treatm...
Role of ILC2 and eosinophils in abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) affects 0.5~3.2% of the general populations in US and worldwide. Besides adjusting lifestyle, open surgery and endovascular stent grafting remain th...
Novel Nutrient Functions and Sensing Mechanisms
Project Summary/Abstract Despite its long history, the nutrient biology field is still facing a plethora of outstanding questions closely related to human health, two of which will...
Testing a culturally targeted narrative video to reduce disparities in the use of genetic counseling and testing in Latina women at-risk of HBOC
ABSTRACT National guidelines recommend that women at increased risk for Hereditary Breast and Ovarian Cancer (HBOC) due to BRCA1/2 mutations be referred for genetic counseling and...
PheMAP: Measured, Automated Profile to Facilitate High Throughput Phenotyping
Electronic health records (EHRs) are a powerful and efficient tool for biological discovery globally. However, a vital step for EHR-based research is valid, accurate, and reliable...
Mycobacterial Lung Diseases in Virginia: sequencing and clinical determinants of relapse and outcome
PROJECT SUMMARY / ABSTRACT Nontuberculous mycobacterial lung diseases, primarily due to M. avium complex (MAC), is an increasing clinical problem nationwide and now overtakes domes...
Control of calcium flux and mitochondrial fission by the Charcot Marie Tooth disease protein Mfn2.
Project summary Charcot-Marie-Tooth disease (CMT) is a hereditary peripheral neuropathy resulting from demyelination and axon degeneration. Many cases of axon degeneration are caus...
Machine Learning Models for Identifying Neural Predictors of TMS Treatment Response in MDD
Transcranial magnetic stimulation (TMS) is an effective and easy-to-tolerate treatment for major depressive disorder (MDD). TMS is costly and time-intensive so identifying markers...
OHSU PREP - Guiding Promising Underrepresented Post-Baccalaureates to be Successful Biomedical Scholars
Project Summary Students from groups underrepresented in science often lack actively mentored, sustained research experiences during their undergraduate years. Absence of direct su...
Leveraging Mechanical Control of Relaxation to Improve Diastolic Function
7. PROJECT SUMMARY/ABSTRACT Impaired diastolic relaxation, an important component of diastolic dysfunction, is present in nearly all patients with heart failure-both with reduced a...
2/3 Genomics of Schizophrenia in the South African Xhosa
PROJECT DESCRIPTION The goal of this international collaborative project, in response to PAR-20-027, is to characterize the genetic architecture of schizophrenia in the Xhosa popul...
T cell invasion of the stem cell compartment during immune-mediated GI damage
Despite the importance of intestinal stem cells (ISCs) for epithelial maintenance in the gastrointestinal (GI) tract and the clinical significance of inflammatory intestinal disord...
Improving Access and Affordability of Adult Hearing Healthcare: Effectiveness of Community-based Interventions in West Central and South Alabama
Abstract Mounting evidence suggests that hearing loss is associated with social isolation, depression and cognitive decline. Loss of hearing has become a growing public health conc...
Chronic Lung Disease and COVID-19: Understanding Severity, Recovery and Rehabilitation Needs (LAUREL Study)
SARS-CoV-2 (SARS2) infection, which leads to COVID-19, is a global pandemic. Chronic lung disease (CLD), particularly chronic obstructive pulmonary disease (COPD), has emerged as a...
Development of an artificial intelligence-driven, imaging-based platform for pretreatment identification of extranodal extension in head and neck cancer
Project Summary. The goal of this project is to develop, optimize, and evaluate an artificial intelligence (AI)- driven, medical imaging platform that utilizes computed tomography...
How do CNS fibroblasts regulate the response to neuroinflammation?
ABSTRACT Fibrosis, defined by the deposition of collagen I, is a devastating pathological event that occurs in many organs including the heart, kidney, liver and lung in response t...
Phase 2 Study of Theophylline for the Treatment of Psuedohypoparathyroidism
Pseudohypoparathyroidism (PHP) is a rare, genetic disorder caused by impaired stimulatory G protein (Gsα) signaling through downregulation of the gene, GNAS.The resultant hormone a...
SCH: Context-aware Freezing of Gait mitigation in real-world setting
This project seeks to reduce the burden of freezing of gait (FoG), which is suffered by over 50% of people living with Parkinson’s disease (PD). FoG is a common, devastating manife...
Elucidating the role and mechanisms by which collagenase producing intestinal bacteria promote colorectal cancer recurrence and metastasis following surgery.
PROJECT SUMMARY / ABSTRACT Colorectal cancer (CRC) is a major health concern with nearly 2-million new cases of CRC diagnosed worldwide in 2019. While surgical resection of the pri...
The role of mitochondria in hematopoietic stem cell self-renewal
Abstract Hematopoietic stem cells (HSC) sustain the production of all blood and immune cells throughout life by differentiating into all blood lineages and regenerate long-lived HS...