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201,169 grants found
Showing 199,721 – 199,740 of 201,169 grants
Protein Kinase Novel 2 (PKN2) in heart
PROJECT SUMMARY The Protein Kinase Novel (PKNs) family of kinases, also known as Protein Kinase C-related kinases, belong to the PKC superfamily. A single nucleotide polymorphism a...
Development of a Tailored Intervention to Increase Veteran Enrollment in Cardiac Rehabilitation
Background: This Veterans Affairs (VA) Health Services Research & Development Career Development Award resubmission is a five-year plan that will enable the candidate, a staff...
Cellular and molecular mechanisms underlying DDX3X syndrome
Abstract Mutations in DDX3X are strongly associated with autism spectrum disorder (ASD), and may account for 1-3% of unexplained developmental delay (DD) in females, making this on...
Neurodevelopment after postnatal Zika virus infection in infant macaques
PROJECT SUMMARY / ABSTRACT Intense research has focused on the neurologic effects of prenatal Zika virus (ZIKV) infection; however, the consequences of postnatal infection early in...
Synaptic Architecture and Mechanisms of Direction Selectivity in Primate Retina
A major research challenge for neurobiology is to understand the neural mechanisms that give rise to an extreme diversity of parallel visual pathways and ultimately the contributio...
Understanding the function of histone H3 as an oxidoreductase enzyme
PROJECT SUMMARY This application proposes to investigate the newly discovered function of histone H3 as an oxidoreductase enzyme, catalyzing the reduction of cupric (Cu+2) ions to...
Molecular and Cellular Pathogenesis of Kidney Disease in Sickle Cell Disorders
PROJECT SUMMARY/ABSTRACT Kidney disorders comprising acute kidney injury (AKI), chronic kidney disease (CKD) and end-stage renal disease (ESRD) account for significant morbidity an...
Impact of Circulating Myeloid Cell Clusters on Anti-Tumor Immunity
Durable outcomes in subsets of solid cancer patients treated with immune checkpoint inhibitors (ICI) or adoptive cell transfer (ACT) immunotherapy has driven interest in gaining a...
Elucidation of a Eukaryotic Chemorepulsion Mechanism
The directed movement of eukaryotic cells away from a source of a chemorepellent appears to play a major role in development and the resolution of inflammation, but very little is...
Kidney PCSK9 in nephrotic syndrome
Summary / Abstract (max 30 lines): Nephrotic syndrome is a major manifestation of human glomerular disease, and patients with this condition develop large amounts of protein in the...
Genome-wide structure-based analysis of protein-protein interactions and networks
Project Summary Our lab works in the general area of computational structural biology although it also includes an experimental component. We carry out theoretical and computationa...
Optimization of Lead BKIs for Cryptosporidiosis Therapy
ABSTRACT: Optimization of Lead BKIs for Cryptosporidiosis Therapy The broad, long-term objective of this research is to develop a therapeutic for treatment of Cryptosporidium infec...
Temporal and Metabolic Regulation of Restimulation-Induced Cell Death (RICD) in Human T Cells
PROJECT SUMMARY/ABSTRACT PI: Snow, Andrew L. The healthy immune system depends upon a balance of proliferation and death of white blood cells, including B and T lymphocytes, to con...
Connecting AMD SNPs to Functions Using Allele-specific Interactions
PROJECT SUMMARY. Age-related Macular Degeneration (AMD) is a retinal neurodegenerative disease that is a major cause of vision loss among the elderly worldwide. Although anti-VEGF...
Does VECAD at Schlemm canal cell-junctions determine IOP and glaucoma risk?
High IOP is a major causal risk factor for glaucoma and is the target of all current glaucoma therapies. This project investigates pathways that control intraocular pressure. Abnor...
Tissue niches for ILC3 development in newborn's lung
PROJECT SUMMARY : Bacterial pneumonia kills more than one million infants around the world each year. Type 3 innate lymphoid cells (ILC3) are critical for lung mucosal defense agai...
Oxylipin Signaling in Congenital Heart Disease
Project summary Congenital heart defects (CHD) constitute the most common type of congenital defect in humans, however the causes for CHD in most cases are unknown. Lipoxygenase-de...
Adaptive population codes for flexible visually-guided behaviors
Summary/Abstract Active vision requires encoding and remembering relevant information based on current task goals. Classic accounts posit that sensory encoding, attentional selecti...
Behavioral and neural properties of spatial direction comprehension in aging and amestic mild cognitive impairment
Project Summary: Spatial navigation is an essential task for living a safe, independent life. Spatial navigation skills decline in normal aging and become progressively impaired in...
Activity-Dependent Mechanisms of Memory Consolidation
PROJECT SUMMARY Vision is an active sense, with eye movements powerfully shaping the acquisition of visual information about the world. This project investigates how motor learning...