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201,169 grants found
Showing 199,761 – 199,780 of 201,169 grants
Translating research into school-based practice via small-group, language-focused comprehension intervention
PROJECT SUMMARY The long-term goal of this research is to translate years of federally-funded basic science on comprehension processes and interventions to provide elementary-age c...
Physiology-driven seizure management post-cardiac arrest
PROJECT SUMMARY/ABSTRACT Dr. Edilberto Amorim is a neurologist with subspecialty training in critical care and epilepsy who aims to employ biomedical technology innovations in brai...
Mechanisms and evolutionary consequences of transposon strategies to counteract host silencing
PROJECT SUMMARY Harboring active transposable elements (TEs) imposes a substantial mutational burden on the host genome. To reduce this burden, most organisms have evolved sophisti...
Coupled Protons and Electrons in Biological Systems
Project Summary/Abstract Controlling the movement of electrons and protons is critical for a wide range of biological processes, including cellular respiration, DNA biosynthesis, a...
Surfactant Protein C Mouse Models: A Fit For Purpose Preclinical Platform For Advancing Discovery In And Treatment Of Idiopathic Pulmonary Fibrosis
ABSTRACT Idiopathic Pulmonary fibrosis (IPF) is a devastating interstitial lung disease (ILD) of older adults characterized by disruption of distal lung architecture that ultimatel...
Combining modeling and experiments to study the evolution of cells with altered ploidy
Project Summary Aneuploidy is a ubiquitous feature of cancer cells, and accumulation of aneuploidy is believed to often happen via tetraploidization (genome doubling) as an interme...
Molecular mechanisms and functions of global chromatin control
Project Summary/Abstract The long term goal of the proposed study is to determine, at the molecular level, mechanisms and functions of chromatin regulation at a global level. Chrom...
Analysis of conserved eukaryotic transcription elongation factors
PROJECT SUMMARY/ABSTRACT The long-term objectives of this project are to increase our understanding of eukaryotic transcription elongation, with a focus on histone chaperones. Hist...
Mechanism of chromatin accessibility, 3D chromosome organization, and their functions in gene regulation
Project Abstract The overall theme of my research program is to understand the formation mechanism of chromatin structure and its role in gene regulation. We plan to address this p...
GATA Factor Mechanisms in Erythroid Regeneration
ABSTRACT Erythropoiesis, the production of red blood cells (RBCs), is fine-tuned to meet physiological demands. During regeneration or “stress erythropoiesis” caused by anemia, a s...
A novel class of long non-coding RNA in regulation of the type I interferonresponse
Project Summary The mammalian genome is pervasively transcribed to generate a complex non-coding transcriptome. A novel class of long non-coding RNA (lncRNA) called DoGs for “Downs...
Highly Selective Catalytic Reactions of Alkenes and Alkynes Relevant to Medicinal and Process Chemistry
Project Summary/Abstract A recent critical analysis of biologically active molecules and reactions most often used for their preparation suggests that fraction of saturated carbons...
SPHINGOLIPID BIOLOGY OF MACROPHAGE IN CORONARY ATHEROSCLEROSIS DEVELOPMENT AND PROGRESSION
Inflammatory macrophages play a key role in the development and progression of the atherosclerosis, leading to myocardial infarction (MI). Sphingolipids are both membrane component...
REACH Pipeline Summer Research Experience for Minority and Underrepresented High School and Undergraduate Students
REACH is an 8-week pipeline summer course for minorities and underrepresented college and high school students interested in careers in neuroscience. Developed, together with Drs.J...
Molecular and Clinical Glycobiology of the Bone Marrow Environment
The life-long production of blood cells requires hematopoietic developmental programs guided by systemic and local signals to convey the dynamic need for these cells. How these sig...
Core A: Administrative Core
Administrative Core - Project Summary/Abstract The Administrative Core is located within the administrative offices of the Blood Research Institute (BRI), the research arm of Versi...
Core B: Glyco-genomics and Bioinformatics
Core B - Project Summary/Abstract This Program Project will investigate the mechanisms by which glycosylation and glycans may alter the function, maintenance, differentiation, and...
Core C: GAGomics and Proteomics
Core C – Project Summary/Abstract Glycosaminoglycans (GAGs) are linear O-linked polysaccharides that modify serine residues for a select number of membrane proteins (e.g., glypican...
Tractable Tandem Ion Mobility Technology using Structures for Lossless Ion Manipulations and Photodissociation
Project Summary In addition to concentration, the orientation and conformation of proteins, carbohydrates, metabolites, and nucleic acids are essential characteristics differentiat...
Project 1: Megakaryocytes as Organizers of the Hematopoietic Environment
Insufficient megakaryopoiesis and thrombopoiesis remain the main cause of persistent thrombocytopenia after hematopoietic stem and progenitor cell (HSPC) transplantation and after...