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201,169 grants found
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Project 2: Extracellular Glycosylation and Blood Cell Production
Project 2 – Project Summary Maintaining hematopoiesis is critical for life. Generating the proper numbers of functional blood cells across all lineages requires cell-intrinsic deve...
Project 3: Role of Glycosaminoglycans in Hematopoiesis
Project 3 – Project Summary/Abstract Glycosaminoglycans (GAGs) contribute to myriad, and very often opposing, functions such as cellular proliferation as well as apoptosis, self-re...
Mitigating sexual stigma within healthcare interactions to improve engagement of MSM in HIV prevention
Long-term objective. My long-term objective is to explore, identify and evaluate acceptable, feasible and appropriate techniques and mechanisms to mitigate HIV-related stigma in he...
Development of Asymmetric Cooperative Gold Catalysis and Beyond
Cooperative catalysis or catalysis involving metal-ligand cooperation is a highly versatile approach in catalysis that have resulted in a myriad of highly efficient synthetic metho...
Regulatory mechanisms of the Hsp90 chaperone machinery
PROJECT SUMMARY The molecular chaperone Heat Shock Protein-90 (Hsp90) is essential for the folding and activity of an array of `client' proteins involved in signal transductio...
MICROBIOTA-DEPENDENT CONTROL OF CLOSTRIDIUM DIFFICILE: THE ROLE OF ACETATE AND IL-22 BINDING PROTEIN
PROJECT SUMMARY The overall goal of this application is to establish avenues through which we can harness the intestinal microbiota to enhance mucosal immune responses against Clos...
Silencing the uroguanylin-GUCY2C gut-brain axis mediates leptin resistance in obesity
PROJECT SUMMARY/ABSTRACT Obesity is a global pandemic with accelerating trends in morbidity, mortality, and medical expenditures. Treatments have been limited in efficacy or burden...
Transcriptional control of retinal neuron specification and maturation.
PROJECT SUMMARY/ABSTRACT Amacrine cells (ACs) are the principle inhibitory neurons of the inner retina, with at least 45 morphologically distinct subtypes that can be distinguished...
Abscission regulation of corticogenesis
Abstract: In order for the brain to develop with proper size and structure, neural stem cells (NSCs) at early ages must make proliferative divisions and maintain their stemness to...
Diffuse optical spectroscopies to assess cerebral hemodynamics in pediatric sickle cell disease
Project Summary Silent cerebral infarction is a serious consequence of sickle cell disease (SCD), affecting ~40% of patients by age 15. Although these injuries accumulate occultly,...
Dynamics of calcium signals control neurotransmitter release in retinal ribbon synapses
Retinal bipolar cells are the first 'projection neurons' of the vertebrate visual system and transmit all of the information needed for vision. Bipolar cells can signal c...
Beta1-selective blockade for prevention of postmenopausal bone loss: A randomized controlled trial
Osteoporosis is a disease of aging that leads to ~2 million fractures and ~$17 billion in healthcare costs annually. Although several drugs are FDA-approved for the treatment of os...
Human Factors of Aging Program
Abstract:The candidate, Mark S Redfern, PhD, is a professor at the University of Pittsburgh with a primary appointment in the Department of Bioengineering, Swanson School of Engine...
Identifying Protein-Protein Network Interactions between COPD Susceptibility Genes
PROJECT SUMMARY Genome-wide association studies (GWAS) of complex diseases like COPD have identified many genomic regions associated with disease, but the molecular mechanisms by w...
Motherhood Biographies and Midlife Women's Health
Abstract Research shows widening health disparities among midlife women since the mid-1980s. However, the mechanisms through which these health gradients operate are not fully know...
A Randomized Controlled Trial: Genetic Counseling Patient Preference Intervention via Electronic Health Record Portal vs. Conventional Genetic Counseling for Women at Elevated Risk for Breast Cancer
PROJECT SUMMARY Women at elevated risk for breast cancer should complete genetic counseling and may require more frequent screening or additional tests (e.g. breast magnetic resona...
Role of the circadian rhythm on endocannabinoid response to an acute stress
Project Summary Cardiovascular (CV) disease is the leading cause of death in the US. Night and rotating shift work, ~20% of the labor force, is associated with a greater incidence...
Investigating cognitive-motor variability to predict driving performance in stroke survivors with MCI
PROJECT SUMMARY/ABSTRACT Dr. Neha Lodha is an Assistant Professor in the Department of Health and Exercise Science at Colorado State University (CSU). Dr. Lodha's long-term ca...
Gene regulatory networks for heart development
PROJECT SUMMARY Congenital heart defects (CHDs) are the most prevalent and serious birth defects, occurring in over 1% of live births. Major subsets of congenital heart defects are...
Early Respiratory Care in Amyotrophic Lateral Sclerosis Patients at High Risk for Respiratory Failure
Project Summary/Abstract Respiratory failure commonly occurs in amyotrophic lateral sclerosis (ALS) and leads to significant morbidity and mortality. The onset of respiratory weakn...