Results for Infrastructure
30,662 grants found
Showing 5,961 – 5,980 of 30,662 grants for "Infrastructure"
SIEVERT: Studying tumour EVolution during External beam Radiation Therapy
Background: Radioresistance is a significant cause of morbidity and mortality in patients diagnosed with cancer.Whilst some malignancies exhibit an intrinsic resistance to radiothe...
Establishing novel patient-like models of Ewing sarcoma to explore response to radiotherapy-drug combinations
Background: 40-50% of Ewing sarcoma patients progress on initial treatment or recur after primary treatment. Around 85% of patients have metastatic disease at recurrence and ≤15% o...
IdentifyinG Radiotherapy and ImmunE ResistanCe Mechanisms In Anal CaNcer (GRECIAN)
Background Anal squamous cell cancer (ASCC) is a rare but rapidly increasing cancer, with approximately 1500 new cases in the UK each year.The UK has led the world in transforming...
Cancer Research UK Newcastle Centre
Cancer Research UK Newcastle Centre
CRUK National Biomarker Centre
With the strategic intent to open-up the world-leading capabilities more nationally, it has been agreed that the biomarker activity in Manchester will be consolidated to form the C...
Investigating Proton and Electron Flash in novel 3D cultures
Background: There is world-wide interest in ultra-high dose rate radiotherapy (FLASH) (typically > 40 Gy/s) as it appears to offer increased normal tissue sparing, compared to c...
CRUK Edinburgh-UCL Brain Tumour Centre Of Excellence 2024
Established in 2018, the CRUK Edinburgh-UCL Brain Tumour Centre of Excellence (CoE) is beginning to change the UK brain tumour research landscape by building a critical mass of res...
Exploiting the radiobiological potential of protons and high-LET radiation
The strategic focus of the proposed Birmingham RadNet Centre (BRNC) is to explore the radiobiological impact of protons and high linear energy transfer (LET) radiation at the molec...
Harnessing radiation biology to increase cancer cure rates
Radiotherapy remains a central pillar of cancer care, contributing to 50% of all cures and improving quality-of-life in many with incurable disease.The reasons why radiotherapy doe...
CRUK Children's Brain Tumour Centre of Excellence 2024
Almost no new treatments of childhood brain tumours have been developed in over 50-years: these diseases continue to kill more children than any other cancer.Therefore, in 2018 we...
CRUK Lung Cancer Centre of Excellence 2024
In 2014 there were few high-quality funding applications for lung cancer research with stagnation in progress contributing to poor outcomes.The CRUK Lung Cancer Centre of Excellenc...
CRUK City of London Radiation Research Centre of Excellence 2024
Over the last five years, CRUK RadNet City of London (CoL) has transformed the radiation research landscape in London, bringing together researchers and clinicians with shared inte...
Overcoming hypoxia mediated resistance to radiotherapy-PARP inhibitor combinations in glioblastoma.
Background: Glioblastoma (GBM) is a cancer of unmet need; average survival is approximately 12 months. The only efficacious treatments are DNA damaging agents: radiotherapy and tem...
Functional profiling and computational models to better understand DDR processes and guide improvements in radiotherapy
Background: The propensity of deficient DNA response and repair components in cancer cells are exploited in radiotherapy treatments.Irradiation leads to damage of cellular molecule...
Cancer Research UK Cambridge Centre
Cancer Research UK Cambridge Centre
Cancer Research UK Oxford Centre
Cancer Research UK Oxford Centre
Hamlet.rt: multi-centre expansion
Background Heuristics, Algorithms and Machine Learning: Evaluation & Testing in Radiation Therapy (Hamlet.rt) is a technology-enabled prospective clinical study aiming to build...
Reducing neurotoxicity from brain irradiation with FLASH radiation and PARP inhibitors
Background: The combination of PARPi and FLASH is of particular interest as both are shown to be modulated by the available oxygen in the irradiated tissue, which increases the pos...
Investigating BH3-mimetic drugs as radiosensitising agents in solid cancers
Background- Radiotherapy (RT) is an effective and potentially curative treatment used for many solid tumours.However, some tumours display innate radio-resistance that leads to the...
Developing and validating a preclinical platform for combining radiotherapy with immunomodulation in hepatocellular carcinoma
Background: Hepatocellular carcinoma (HCC) is the 3rd largest cause of cancer deaths worldwide and is a recognised cancer of unmet need. Whilst curative options exist, only a small...