Results for Health
130,725 grants found
Showing 125,781 – 125,800 of 130,725 grants for "Health"
Augmenting cancer checkpoint immunotherapies via microbially-derived metabolites
PROJECT SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICIs) have significantly improved long-term survival across diverse cancer types including melanoma, non-small cell lung canc...
Biomarkers of disease severity and progression in Parkinson's
Background: Parkinson’s disease (PD) is the second most common neurodegenerative disorder, and it is even more prevalent in veterans, due to military-specific exposures that increa...
Augmenting cancer checkpoint immunotherapies via microbially-derived metabolites
PROJECT SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICIs) have significantly improved long-term survival across diverse cancer types including melanoma, non-small cell lung canc...
Impact of microbiota-derived metabolites on traumatic brain injury-related neurodegeneration
Traumatic brain injury (TBI)-related neurodegeneration (TReND) is increasingly recognized as a major health concern and cause of cognitive decline. Neuroinflammation, a proposed me...
Deciphering Mechanisms of Astrocyte-BBB Interaction in Normal and Ischemic Stroke
SUMMARY AND ABSTRACT Astrocytes are the most diverse glial cell type and maintain essential interactions with endothelial cells to form the blood-brain barrier (BBB). The BBB plays...
NSF-DFG Confine: Plasma-Catalysis in Confined Spaces for Cold Start NOx Abatement in Automotive Exhaust
This project seeks to transform traditional chemical processing to ensure a sustainable future. Catalysis, which facilitates desired chemical reactions, has played a key role in de...
CAREER: Wetting and dynamics on soft and swollen polymeric surfaces
Soft and swollen polymers are critical for many areas of science and technology, from biological and synthetic tissues to flexible devices and non-stick coatings. These materials c...
IRES Track I: Collaborative Research: Interdisciplinary Research in Korea on Applied Smart Systems (IRiKA) for Undergraduate Students
Interdisciplinary Research in Korea on Applied smart systems (IRiKA) for Undergraduate Students will provide a cohort of five US undergraduate students per year with the opportunit...
Sialic acid mediated interbacterial adhesion among oral bacteria
PROJECT SUMMARY/ABSTRACT Glycan-mediated interbacterial coadhesion is a critical part of multispecies biofilm formation in the human mouth. Certain strains of oral streptococci exp...
Orexin Signaling in the Mouse Cochlea
The research undertaken for this proposal is significant because it represents the first investigation of the role of Orexin signaling in the cochlea and as such, will result in no...
Elucidating genetic mechanisms of Clostridioides difficile pathogenesis and patient immune manipulation
Project Summary In their 2019 Antibiotic Resistance Threats Report, the Centers for Disease Control and Prevention listed Clostridioides (formerly Clostridium) difficile as an urge...
2023 Glial Biology: Functional Interactions Among Glia and Neurons Gordon Research Conference and Gordon Research Seminar
ABSTRACT The Gordon Research Conference on Glial Biology entitled Glial networking: Cell biology, physiology and plasticity will host its 10th meeting in 2023 in Ventura, Californi...
Elucidating genetic mechanisms of Clostridioides difficile pathogenesis and patient immune manipulation
Project Summary In their 2019 Antibiotic Resistance Threats Report, the Centers for Disease Control and Prevention listed Clostridioides (formerly Clostridium) difficile as an urge...
Orexin Signaling in the Mouse Cochlea
The research undertaken for this proposal is significant because it represents the first investigation of the role of Orexin signaling in the cochlea and as such, will result in no...
Identification of Trichomonas vaginalis resistance targets to inform future drug development
PROJECT SUMMARY/ABSTRACT The purpose of this NIH F31-Diversity grant application is to provide support for the PI, Keonte Graves, for mentored research and career development activ...
Comprehensive investigation of SP7 during the osteoblast-to-osteocyte transition
Project Summary/Abstract Many pathologic or disease conditions can now be ascribed to disrupted osteocyte functions. However, a limited number of osteocyte-enriched genes have been...
G6PC Enzymology, Structure, Function and Role in the Regulation of Fasting Blood Glucose
Project Summary: Glucose-6-phosphatase catalytic subunits (G6PCs) hydrolyze glucose-6-phosphate (G6P) to glucose and inorganic phosphate. G6PC2 is predominantly expressed in pancre...
Towards a Quantum-Mechanical Understanding of Redox Chemistry in Proteins
Project Summary/Abstract Metals are found in almost every protein that serves a biological function, and understanding their role in the chemical reactions that guide metabolism an...
Synthetic Lethal Targeting of SETD2 in Renal Cell Carcinoma
ABSTRACT Clear cell renal cell carcinoma (ccRCC) accounts for ~75% of kidney cancers and is the 8th leading cause of cancer death in the United States. After completion of The Canc...
Eligibility criteria design for Alzheimer's trials with real-world data and explainable AI
ABSTRACT Clinical trials are often conducted under idealized and rigorously controlled conditions to ensure internal validity (maximizing potential treatment efficacy) while balanc...