Results for Health
130,725 grants found
Showing 125,801 – 125,820 of 130,725 grants for "Health"
Strategies to Block Skin Wound Infection by Intercepting Bacterial Cell-to-Cell Signaling
PROJECT SUMMARY This R21 project will use potent chemical inhibitors of bacterial cell-to-cell signaling to develop new materials and explore innovative approaches to prevent bacte...
Renewal of The Mid-America CTSA Consortium (MACC) as a Regional Clinical Center for SIREN
The Mid-America CTSA Consortium (MACC) submits this renewal application to continue as a Regional Clinical Center (RCC) for the “Strategies to Innovate EmeRgENcy Care Clinical Tria...
G6PC Enzymology, Structure, Function and Role in the Regulation of Fasting Blood Glucose
Project Summary: Glucose-6-phosphatase catalytic subunits (G6PCs) hydrolyze glucose-6-phosphate (G6P) to glucose and inorganic phosphate. G6PC2 is predominantly expressed in pancre...
Strategies to Block Skin Wound Infection by Intercepting Bacterial Cell-to-Cell Signaling
PROJECT SUMMARY This R21 project will use potent chemical inhibitors of bacterial cell-to-cell signaling to develop new materials and explore innovative approaches to prevent bacte...
Synthetic Lethal Targeting of SETD2 in Renal Cell Carcinoma
ABSTRACT Clear cell renal cell carcinoma (ccRCC) accounts for ~75% of kidney cancers and is the 8th leading cause of cancer death in the United States. After completion of The Canc...
Eligibility criteria design for Alzheimer's trials with real-world data and explainable AI
ABSTRACT Clinical trials are often conducted under idealized and rigorously controlled conditions to ensure internal validity (maximizing potential treatment efficacy) while balanc...
Identification of Trichomonas vaginalis resistance targets to inform future drug development
PROJECT SUMMARY/ABSTRACT The purpose of this NIH F31-Diversity grant application is to provide support for the PI, Keonte Graves, for mentored research and career development activ...
Towards a Quantum-Mechanical Understanding of Redox Chemistry in Proteins
Project Summary/Abstract Metals are found in almost every protein that serves a biological function, and understanding their role in the chemical reactions that guide metabolism an...
Impact of mammalian target of rapamycin inhibitor therapy on aging-related outcomes
PROJECT SUMMARY In numerous experimental studies, mammalian target of rapamycin (mTOR) inhibitors, such as rapamycin, prolong lifespan, prevent the progression of Alzheimer's...
An interrogation of synaptic dysfunctions arising from human cognitive disease gene mutations using opto-physiological and neurochemical strategies.
More than 50 million people in the world are living with dementia today, and approximately £550 billion is spent each year on their health and social care.Alzheimer'...
Characterization of LINE-1 reverse transcriptase activity
Project Summary The objective of this research proposal is to characterize the enzymatic activities of the reverse transcriptase (RT) of the human long interspersed element 1 (LINE...
Genetic Epidemiology of GERD in COPD
PROJECT SUMMARY The purpose of this NIH F31 application is to obtain support for the PI, Ava Wilson, for mentored research and career development activities within her PhD training...
Exercise prehabilitation in colorectal cancer: establishing mechanisms of adaptation to advance optimisation and stratification.
Bowel cancers, such as colon or rectal, are a leading cause of death, especially in those over the age of 60-years. However, if caught early, these cancers also present an opportun...
Reversal of ventilatory depression by drug mixtures
ABSTRACT For the first time, over 100,000 deaths were caused by drug overdose in a 12-month period (April 2020 - April 2021) in the United States. Synthetic opioids, primarily fent...
Influence of viral and immune interventions on early events following oral SIV infection
A majority of HIV infections occur at a mucosal surface, which can include the rectal, vaginal, penile or oral mucosa. Oral HIV transmission occurs in two distinct settings, breast...
Influence of viral and immune interventions on early events following oral SIV infection
A majority of HIV infections occur at a mucosal surface, which can include the rectal, vaginal, penile or oral mucosa. Oral HIV transmission occurs in two distinct settings, breast...
Identifying the Most Effective Adjuvant(s) for Leading Group A Streptococcal Vaccine Antigens in Preclinical Mouse and Nonhuman Primate Models
SUMMARY The leading human bacterial pathogen group A Streptococcus (GAS) causes over 700,000,000 cases of superficial disease such as pharyngitis and pyoderma each year but can als...
Impact of microbiota-derived metabolites on traumatic brain injury-related neurodegeneration
Traumatic brain injury (TBI)-related neurodegeneration (TReND) is increasingly recognized as a major health concern and cause of cognitive decline. Neuroinflammation, a proposed me...
Vanderbilt Stimulating Access to Research in Residency (V-StARR)
The goal of this application is to continue the highly successful Vanderbilt - Stimulating Access to Research in Residency; V-StARR) mentored training program for residents in Medi...
Sinusoidally modulated fluorescence imaging for stress detection in plants
Crop plants are subject to multiple environmental stresses that limit their productivity by impacting photosynthetic performance. Despite years of selective breeding, crops are not...