Results for Health
130,725 grants found
Showing 125,841 – 125,860 of 130,725 grants for "Health"
Metabolic Control of Proliferation and Differentiation in Oligodendrocytes
Project Summary Myelin is critical for proper brain function and its dysfunction, damage or inappropriate formation has been reported in a wide range of neurological and psychiatri...
Utilizing Human Brain Organoids to Model the Differential Effects of SCN8A Mutation on Cortex and Hippocampus
Project Summary/Abstract Epilepsy is a severe and debilitating disease and a significant public health concern. Epilepsy is also a disease without a medical cure, and a disease whe...
Racial Differences in Prostate Cancer Molecular Subtyping
ABSTRACT Black men have one of the highest risks of aggressive prostate cancer (PC) in the world. Even in an equal access setting, we found disparities persist, arguing for a biolo...
ROS mechanisms in BAV aortopathy
PROJECT SUMMARY Ascending aortic aneurysmal disease is a major worldwide health problem.Bicuspid aortic valve (BAV)- associated aortopathy represents the largest subset of affected...
Natural killer cells in pulmonary ischemia-reperfusion injury
This is an application for a BLRD CDA-2 award for Dr. Daniel Calabrese, a staff physician at the SFVA and an Assistant Professor in the Division of Pulmonary and Critical Care at t...
Genetics & Genomics Training Program
This application is a request for support for the Predoctoral Training Program in Genetics & Genomics at Baylor College of Medicine. This Program started in 1987 and has been f...
Novel strategy combined with targeted radiation therapy unleashes potentantitumor immunity in HPV + head and neck cancer
Project Summary/Abstract The overwhelming public health burden of HPV-associated head and neck cancer (HNC) has created great demand for novel, broadly effective therapies with red...
Chronic Versus Acute Transplantation of Neural Tissues for TBI-Induced Cortical Injuries
PROJECT SUMMARY/ABSTRACT Injury to the cerebral cortex occurs frequently across the spectrum of severity in traumatic brain injury (TBI). No therapies exist to counter the neurolog...
Establishing a Novel Instrumental Model for Elucidating Mitochondrial DNA-Associated Dysfunction and Pathogenicity
Project Summary/Abstract The Shao group at Iowa State University aims to leverage their expertise in genetic tool development to assemble a comprehensive mitochondrial genetic tool...
Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants
Project Summary/Abstract There is growing societal and scientific interest in using genomic sequencing (GS) as screening to identify genetic predispositions for disease early in li...
MyGI Diet for Colorectal Cancer Prevention
PROJECT SUMMARY Despite the large body of research that has identified the impact of diet on cancer risk, little has been done to translate these findings to clinical settings. Her...
Racial Differences in Biomarkers and Therapeutic Targets for Chronic Itch
Itch, or pruritus, is a commonly reported symptom with over 7 million clinician visits annually in the United States. Indeed, the Global Burden of Disease Study by the World Health...
A novel role for E2fs: E2f7 and E2f8 control motile ciliogenesis
ABSTRACT Multiciliated cells (MCCs) occur in airways, ependyma and oviduct and are crucial for respiration, neurogenesis and fertility. MCCs nucleate up to 300 motile cilia at thei...
PRROPS: Pathways of Risk and Resilience for Overlapping Pain and Sensitization
Chronic pain affects >100 million American adults with estimated costs of up to $1 trillion annually.Older adults are at increased risk of having multiple painful conditions and...
Vascular Effects on Astrocyte Functions in Young and Aging Brains
The brain is an incredibly energy-demanding organ, consuming ~20% of the total blood supply despite constituting only approximately 2% of body weight. Thus, the brain requires a co...
A novel role for E2fs: E2f7 and E2f8 control motile ciliogenesis
ABSTRACT Multiciliated cells (MCCs) occur in airways, ependyma and oviduct and are crucial for respiration, neurogenesis and fertility. MCCs nucleate up to 300 motile cilia at thei...
University of Rochester Vaccine and Treatment Evaluation Unit(VTEU)-DMID 21-0012
The Vaccine and Treatment Evaluation Units (VTEUs) are a critical resource for the NIAID Infectious Diseases Clinical Research Consortium to conduct clinical research and trials to...
Polyamines drive glioblastoma progression
PROJECT SUMMARY Glioblastoma (GBM) is the most prevalent primary malignant brain tumor and is highly lethal with a median survival of approximately 20 months. GBM is incurable desp...
Feasibility of Objective Measures and Outpatient Washout in Disease-Modifying Trials for Parkinson's Disease
PROJECT SUMMARY AND CAREER DEVELOPMENT ABSTRACT There is no therapy that slows the progression of any symptom of Parkinson’s disease (PD), a progressive, age-related neurodegenerat...
Xenon MRI in Pulmonary Hypertension
ABSTRACT The diagnosis and follow-up of patients with pulmonary arterial hypertension (PAH) continues to be challenging, with a lack of unambiguous biomarkers that reflect the cour...