Results for Health
130,725 grants found
Showing 125,941 – 125,960 of 130,725 grants for "Health"
Transcriptional Regulators in Aging Macrophages
As key governors of tissue integrity, macrophages are implicated in many age-related diseases.Macrophages are a plastic myeloid immune cell type found in nearly every tissue of the...
Regulation and Function of Oral Resident Memory T Cells
Project Summary/Abstract Memory T cells chronicle an individual?s infectious past and afford protection to reinfection.Historically defined in blood and subdivided based on their a...
Novel strategy combined with targeted radiation therapy unleashes potent antitumor immunity in HPV + head and neck cancer
Project Summary/Abstract The overwhelming public health burden of HPV-associated head and neck cancer (HNC) has created great demand for novel, broadly effective therapies with red...
MyGI Diet for Colorectal Cancer Prevention
PROJECT SUMMARY Despite the large body of research that has identified the impact of diet on cancer risk, little has been done to translate these findings to clinical settings. Her...
Utilizing Human Brain Organoids to Model the Differential Effects of SCN8A Mutation on Cortex and Hippocampus
Project Summary/Abstract Epilepsy is a severe and debilitating disease and a significant public health concern.Epilepsy is also a disease without a medical cure, and a disease wher...
Chronic Versus Acute Transplantation of Neural Tissues for TBI-Induced Cortical Injuries
PROJECT SUMMARY/ABSTRACT Injury to the cerebral cortex occurs frequently across the spectrum of severity in traumatic brain injury (TBI).No therapies exist to counter the neurologi...
A Rigorous Application of the RE-AIM Framework to Examine a Pediatric Obesity Intervention
PROJECT SUMMARY/ABSTRACT Pediatric obesity contributes to life-long chronic diseases and shortened life expectancy, making it a public health priority.Rural children have dispropor...
Defining mechanisms of perianal fistula inception in African and European ancestry Crohn's disease patients
PROJECT SUMMARY Crohn?s disease (CD) is characterized by progressive, transmural inflammation that can affect any region of the gastrointestinal tract.Penetrating complications, mo...
Characterization of the human antibody response to a novel neutralizing HIV-1 epitope
PROJECT SUMMARY The HIV pandemic is one of the most profound global human health challenges of our time, with 75 million people infected and 32 million dead from AIDS-related illne...
Comprehensive Outcome Assessment after Severe Acute Brain Injury: Advanced Symptoms and End-of-Life Care Needs
PROJECT SUMMARY/ABSTRACT Every 3 minutes in the United States, a person dies after suffering a severe acute vascular brain injury (SABI): an ischemic stroke, intracerebral hemorrha...
Biomechatronics Device for Diagnosis/Therapy of Anorectal Disorders
ABSTRACT Defecatory disorders such as chronic constipation (CC) and fecal incontinence (FI) affect 25% of the population and the incidence is rising. These disorders pose a major h...
Biomechatronics Device for Diagnosis/Therapy of Anorectal Disorders
ABSTRACT Defecatory disorders such as chronic constipation (CC) and fecal incontinence (FI) affect 25% of the population and the incidence is rising. These disorders pose a major h...
Comprehensive Outcome Assessment after Severe Acute Brain Injury: Advanced Symptoms and End-of-Life Care Needs
PROJECT SUMMARY/ABSTRACT Every 3 minutes in the United States, a person dies after suffering a severe acute vascular brain injury (SABI): an ischemic stroke, intracerebral hemorrha...
Comprehensive Outcome Assessment after Severe Acute Brain Injury: Advanced Symptoms and End-of-Life Care Needs
PROJECT SUMMARY/ABSTRACT Every 3 minutes in the United States, a person dies after suffering a severe acute vascular brain injury (SABI): an ischemic stroke, intracerebral hemorrha...
Comprehensive Outcome Assessment after Severe Acute Brain Injury: Advanced Symptoms and End-of-Life Care Needs
PROJECT SUMMARY/ABSTRACT Every 3 minutes in the United States, a person dies after suffering a severe acute vascular brain injury (SABI): an ischemic stroke, intracerebral hemorrha...
Pathophysiology of Diabetic Gastroparesis
PROJECT SUMMARY/ABSTRACT Diabetes mellitus is associated with multiple complications including diabetic gastroparesis. The systemic effects of diabetes modify all cells in the body...
Pathophysiology of Diabetic Gastroparesis
PROJECT SUMMARY/ABSTRACT Diabetes mellitus is associated with multiple complications including diabetic gastroparesis. The systemic effects of diabetes modify all cells in the body...
Evaluation and Optimization of a Just-in-Time Messaging Intervention to Reduce Alcohol-Facilitated Intimate Partner Violence Perpetration Among At-Risk Young Adult Men and Women
PROJECT SUMMARY Young adult men and women perpetrate intimate partner violence (IPV) at high rates. A summary of over 30-years of research concludes that alcohol is a causal factor...
Evaluation and Optimization of a Just-in-Time Messaging Intervention to Reduce Alcohol-Facilitated Intimate Partner Violence Perpetration Among At-Risk Young Adult Men and Women
PROJECT SUMMARY Young adult men and women perpetrate intimate partner violence (IPV) at high rates. A summary of over 30-years of research concludes that alcohol is a causal factor...
Tailored siRNA delivery to human endothelium to inhibit and reverse inflammatory damage following ischemia reperfusion injury in the kidney
Abstract Ischemia reperfusion injury (IRI) causes endothelial inflammation and microvascular rarefaction that leads to adverse kidney graft outcomes in organ transplant. Direct tre...