Results for Health
130,725 grants found
Showing 126,001 – 126,020 of 130,725 grants for "Health"
Quantification of Liver Fibrosis with MRI and Deep Learning
Project Summary/Abstract Chronic liver disease (CLD) is a common cause of morbidity and mortality in the U.S. and throughout the world. In 2017, CLD had an age-adjusted death rate...
A Simulation Modeling Study to Support Personalized Breast Cancer Prevention and Early Detection in High-Risk Women
Abstract: Personalized care is complex in this unprecedented era of discovery and ‘big data’. The proposed study focuses on the real-world choices facing over 100,000 US women each...
Blood Pressure, Obesity, and Diabetes in Relation to Perinatal and Postpartum Complications
PROJECT SUMMARY/ABSTRACT Hypertensive disorders in pregnancy (HDP) are a leading cause of maternal morbidity, affecting over 350,000 pregnant U.S. women annually. HDP rates increas...
Exploring Common Biological Pathways Underlying Insulin Resistance and Alzheimer Disease using Genetic and Omic Tools
Project Summary / Abstract Insulin resistance (IR) is a major risk factor for Alzheimer’s disease (AD) but the mechanisms by which IR predisposes to AD is unknown, notably, if IR i...
A Preventive Care Approach to Mitigate the Impact of Pediatric ALL Treatment on Sleep
Project Summary Over 50% of pediatric cancer patients report problems with their sleep, characterized by insomnia disorder symptoms. This results in considerable physical and psych...
Estimating the risk for and severity of respiratory infections attributable to CFTR heterozygosity
Project Summary/Abstract 1 Cystic fibrosis is one of the most common autosomal regressive genetic disorders in the United States: 2 approximately 1 out of 32 Caucasians and 1 out o...
Regulation of DNA Replication Timing by Origin Recognition Complex (ORC) Phosphorylation
PROJECT SUMMARY Successful duplication of the genome requires the accurate replication of billions of bases. Failure to do so results in genomic instability and ultimately a host o...
Re-Connect: Personalized, Non-Monetary Smartphone-based Rewards for Smoking Cessation
Project Summary Smoking is the number one cause of preventable death in the United States (U.S.). Approximately 14% of U.S. adults are current cigarette smokers, and about 7 out of...
Adaptation and Refinement of a Clinically Applicable Phenotypic Battery to Individualize Opioid Use Disorder Treatment for Women Through the Postpartum Period
PROJECT SUMMARY Opioid overdose is a leading cause of pregnancy-associated mortality with most of these events occurring through the 12 months after delivery rather than the 9 mont...
Uncovering the role of macrophage/vascular crosstalk in tissue aging
Billions of cells die every day in our bodies as a result of normal tissue turnover and environmental stress.Macrophages are an immune cell population that play a critical role in...
Trajectories of socially regulated gene expression, methamphetamine use, and viral load among HIV-positive men who have sex with men (MSM) receiving contingency management
PROJECT ABSTRACT The K01 Mentored Research Scientist Development Award will provide Dr.Michael Li with invaluable research experience, mentored training from interdisciplinary facu...
Development of 4D Flow MRI for Risk Stratification of Variceal Bleeding in Cirrhosis
PROJECT SUMMARY: The overarching goal of our research is to improve the management and health of an estimated 1 million Americans suffering from end-stage liver disease (cirrhosis)...
Microbial and Host Factors that Promote Epithelial Disruption and S. pneumoniae Transit out of the Lung
Project Summary Streptococcus pneumoniae causes ~900,000 cases of pneumococcal pneumonia annually in the US, with a mortality rate of 5-7%, making this disease a major health and f...
Re-Connect: Personalized, Non-Monetary Smartphone-based Rewards for Smoking Cessation
Project Summary Smoking is the number one cause of preventable death in the United States (U.S.). Approximately 14% of U.S. adults are current cigarette smokers, and about 7 out of...
The Impact of Early Life Stress on Reward and Body Weight
PROJECT SUMMARY My long-term professional goal is to become a successful, independent scientist with a research program focused on obesity and the neurobiological regulation of fee...
A Simulation Modeling Study to Support Personalized Breast Cancer Prevention and Early Detection in High-Risk Women
Abstract: Personalized care is complex in this unprecedented era of discovery and ?big data?.The proposed study focuses on the real-world choices facing over 100,000 US women each...
A Preventive Care Approach to Mitigate the Impact of Pediatric ALL Treatment on Sleep
Project Summary Over 50% of pediatric cancer patients report problems with their sleep, characterized by insomnia disorder symptoms.This results in considerable physical and psycho...
ANALYSIS OF INTRAHEPATIC MACROPHAGE PROFILES FOR PREDICTING RISK OF FIBROSIS DEVELOPMENT IN PATIENTS WITH DIFFERENT TYPES OF CHRONIC LIVER DISEASE
PROJECT SUMMARY/ABSTRACT Cirrhosis and hepatocellular carcinoma are increasing health and economic burdens.Non-alcoholic fatty liver disease (NAFLD/NASH), alcohol-associated liver...
Lens β-Amyloid Biomarker for Early Detection of Preclinical Alzheimer's Disease in the Framingham Study
Recent research advances have led to detailed understanding of the pathogenesis of Alzheimer's disease (AD) and development of emerging disease-modifying therapies. Yet effect...
The Brain and Maternal Microchimerism
PROJECT SUMMARY/ABSTRACT Microchimerism (Mc) refers to harboring a small amount of cells or DNA from a genetically distinct individual.Many years after the physical union of mother...