Results for Health
130,725 grants found
Showing 126,161 – 126,180 of 130,725 grants for "Health"
The role of iris biomechanics and sex differences in primary angle-closure glaucoma
Primary angle-closure glaucoma (PACG) is a significant cause of irreversible blindness worldwide, affecting c. 17M people. PACG is more prevalent among women; unfortunately, the un...
Milk fat globule-EGF factor 8 and hepatocyte apoptosis-induced liver wound healing response
Liver injury-associated diseases remain a major public health problem in the U.S. and VA healthcare system. Evidence shows that liver injury can persist if either etiologic agents...
The role of gasdermins in microglial activation and neurodegeneration in ALS/FTD
7. Project Summary/Abstract The goal of this proposal is to elucidate a role for microglial gasdermin-D in the severity of neurodegeneration in models of amyotrophic lateral sclero...
The role of VSNL1 in human heart rate regulation
PROJECT SUMMARY In the heart, pacemakers or sinoatrial node cells (SAN) initiate and maintain a rhythmic beating pattern that can respond to external stimuli, including neurotransm...
Structural factors Impacting community Violence (STRIVE): The Role of Minimum Wage, COVID-19, and Discrimination
ABSTRACT: Violent deaths are responsible for the most person-years of life lost among people 18 to 50-years old in the United States. Further, violence inflicts a disproportionate...
Sleep and circadian rhythm phenotypes and mechanisms associated with opioid use disorder treatment outcomes
Opioid use disorder (OUD) is a rapidly escalating public health crisis with recent evidence suggesting that close to 70% of drug overdoses involved opioids in the last year. Althou...
Validation of a Virtual Still Face Procedure and Deep Learning Algorithms to Assess Infant Emotion Regulation and Infant-Caregiver Interactions in the Wild
“This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis. The NIH HEAL Initia...
Dissecting the functional relevance of unique subpopulations of striatal dopamine receptors in opioid use disorder
PROJECT SUMMARY The opioid epidemic has skyrocketed in the United States. Despite the enormous public health impact, the basic mechanisms underlying the development of opioid use d...
Development of novel polysomnography-based digital biomarkers to predict Alzheimer’s disease and Parkinson’s disease in real world settings
PROJECT SUMMARY/ ABSTRACT One of the greatest unmet challenges in the management of neurodegenerative diseases is the early diagnosis of Alzheimer's disease and related dement...
Evaluation of a peer recovery support program adapted to target retention in clinic-based medication for opioid use disorder treatment
PROJECT ABSTRACT Drug overdoses are at record levels in the US, driven primarily by the ongoing opioid use disorder (OUD) epidemic. Medications for opioid use disorder (MOUD) have...
Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting- A Randomized Clinical Trial
PROJECT SUMMARY/ABSTRACT Coronary heart disease (CHD) is a common health issue, requiring over 230,500 patients to undergo coronary artery bypass grafting (CABG) each year in the U...
Engineering nanosponges to sequester bacterial exotoxins for protection against severe infection
Bacterial infections represent a significant challenge to clinicians and contribute substantially to healthcare costs worldwide. This challenge has been exacerbated by the rise in...
Drivers of Healthy Start uptake across England and Liverpool
Recent data in the UK reveal a concerning increase in food insecurity, affecting 25% of households with children in September 2022, up from 10% in January 2021. This surge has disp...
Macrophage NR4A nuclear receptors in tuberculosis pathogenesis
PROJECT SUMMARY Alveolar macrophages (AMs) are a critical cell population in the homeostasis of the lung, needing to clear pathogens and debris from the alveoli without compromisin...
Multi-organ culture and pumping systems for ex vivo models of immunity in hybrid tissue-chips
Multi-organ culture and pumping systems for ex vivo models of immunity in hybrid tissue-chips A better understanding of cellular and molecular communication between the lymph node...
CAREER: Probing Specificity and Competition in the Lipid Droplet Proteome
Lipid droplets (LD) are the cellular hubs of energy storage and lipid distribution. As such they play a central role in a wide range of health issues from obesity and diabetes to a...
Integrating patient-reported outcomes and T-cell receptor sequencing to predict immune-related adverse events
Abstract. This proposal is disease agnostic and patient centered, focusing on symptoms associated with side effects of immune checkpoint inhibitors (ICPis). Although ICPis are effe...
ADR England Community Catalyst: Children at risk of poor outcomes
National and local organisations produce a wealth of valuable data, which can be used to understand how we can reduce the number of children at risk of poor social, health and educ...
Estimation of risk associated with zoonotic tuberculosis in South India
PROJECT SUMMARY Tuberculosis (TB) in humans results from infection with members of the Mycobacterium tuberculosis complex (MTBC). The disease is endemic in many parts of the world....
Effects of Sex on the Elastogenesis of Vascular Elastic Fibers
PROJECT SUMMARY – Effects of Sex on the Elastogenesis of Vascular Elastic Fibers Elastic fibers and laminae are responsible for compliance and elastic recoil in many tissues, inclu...