Results for Health
130,725 grants found
Showing 126,281 – 126,300 of 130,725 grants for "Health"
Evaluating the Implementation of Specialist Palliative Care for Patients with Advanced Heart Failure
Project Summary Over 280,000 people die from advanced heart failure each year in the United States. This population experiences burdensome symptoms, frequent hospitalizations, and...
The role of iris biomechanics and sex differences in primary angle-closure glaucoma
Primary angle-closure glaucoma (PACG) is a significant cause of irreversible blindness worldwide, affecting c. 17M people. PACG is more prevalent among women; unfortunately, the un...
Dissecting the functional relevance of unique subpopulations of striatal dopamine receptors in opioid use disorder
PROJECT SUMMARY The opioid epidemic has skyrocketed in the United States. Despite the enormous public health impact, the basic mechanisms underlying the development of opioid use d...
AppalTRuST Project 2: Exposure to tobacco marketing for novel tobacco products and associations with future tobacco use in Appalachian young adults: tobacco regulatory science implications
ABSTRACT – Project 2 Federal tobacco regulatory policies enacted by the US Food and Drug Administration (FDA) are critical to curb the tobacco epidemic in rural Appalachia and redu...
Dissecting Behavioral and Neural Mechanisms of Hand Dexterity after Stroke for Effective Rehabilitation
PROJECT SUMMARY Following a stroke, hand dexterity does not recover fully for most patients, significantly reducing quality of life. Optimal and effective assessment and therapies...
Improving Function and Reducing Opioid Use for Patients with Chronic Low Back Pain in Rural Communities through Improved Access to Physical Therapy using Telerehabilitation
Project Summary Chronic low back pain (LBP) imposes tremendous burden on affected individuals, healthcare systems, and society. LBP has been identified as the most common cause of...
Therapeutic modulation of a proteomic HCC risk signature with statins in patients with liver cirrhosis
Hepatocellular carcinoma (HCC) is a major cirrhosis complication producing an alarming rise in mortality. The prognosis for HCC is poor due to extremely high recurrence rate even a...
Therapeutic modulation of a proteomic HCC risk signature with statins in patients with liver cirrhosis
Hepatocellular carcinoma (HCC) is a major cirrhosis complication producing an alarming rise in mortality. The prognosis for HCC is poor due to extremely high recurrence rate even a...
Multi-scale and multi-modality imaging of neuropathology in VCID
PROJECT SUMMARYMRI and histopathology are two key methods for all research into age-related cognitive impairment and dementia and they have brought key insights into disease mechan...
Multi-scale and multi-modality imaging of neuropathology in VCID
PROJECT SUMMARYMRI and histopathology are two key methods for all research into age-related cognitive impairment and dementia and they have brought key insights into disease mechan...
Pharmacogenetic Refinement of the Warfarin Dose Using Machine Learning
Warfarin is an anticoagulant that prevents venous and arterial clots but doubles the risk of major hemorrhage. Over the past decade, warfarin use has caused more medication-related...
Center for Targeted Therapeutics
SUMMARY The Center for Targeted Therapeutics (CTT) was established in 2014 at the University of South Carolina (USC), with the mission to develop the institutional research in the...
Type I IFN-dependent and independent contributions to the outcomes of early innate immune cell interactions during HIV/TB co-infection
PROJECT SUMMARY/ABSTRACT Granuloma formation is a feature of tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (Mtb) infection. Alveolar macrophages (alvMF) are cen...
Point-of-care Nucleic Acid Amplification Test for pangenomic Hepatitis C diagnosis in outpatient clinics
ABSTRACT Hepatitis C virus (HCV) infection is a widely prevalent bloodborne infection, with approximately 71 million global (2.4 million in USA) chronic infections worldwide. HCV i...
Development of a Universal Vaccine Against Leptospirosis
PROJECT SUMMARY Leptospirosis, an emerging infectious disease, is a leading zoonotic cause of morbidity and mortality worldwide, conveying the greatest burden to subsistence farmer...
Development of Integrated Precision Medicine Models in Adults with Cardiovascular Disease
PROJECT SUMMARY This application aims to use existing data within the All of Us Researcher Workbench to improve our ability to identify cardiovascular disease (CVD) patients treate...
Preventing Drug Use Onset and Progression toward Addiction during a CriticalTransition Period: Optimizing an Online Intervention for High School Seniors
PROJECT SUMMARY/ABSTRACT The overall objective of the proposed research is to optimize a readily scalable online behavioral intervention that will prevent and reduce substance use...
Investigating the bidirectional relationship between circadian rhythms and cannabinoid use
PROJECT SUMMARY/ABSTRACT Cannabis use is on an upward trajectory due to recent decriminalization and legalization. This increased use is associated with numerous health and behavio...
Optimization of a carbon monoxide (CO) sensing hemoprotein for applications as an antidote for CO poisoning and a biosensor for CO detection in living cells
PROJECT SUMMARY/ABSTRACT Carbon monoxide (CO) inhalation is a leading cause of human poisoning in the United States, resulting in about 50,000 cases and at least 1,500 deaths annua...
Limiting Dysglycemia Around Physical Activity for People with Type 1 Diabetes Using Activity-Aware Automated Insulin Delivery – the APEX Project.
In this project we aim to transform glycemic control during physical activity (PA) among persons with Type 1 diabetes (PwD) by testing three novel complementary approaches toward a...