Results for Health
130,725 grants found
Showing 126,381 – 126,400 of 130,725 grants for "Health"
The role of the microbiome in hepatic encephalopathy pathogenesis and treatment
Project Summary/Abstract Hepatic encephalopathy (HE) is a complication of cirrhosis characterized by cognitive, psychological, and motor dysfunction that is associated with decreas...
A Clinical Trial Readiness Study of Patient Reported Outcome Measures in Thrombotic Thrombocytopenic Purpura (TTP)
PROJECT SUMMARY/ABSTRACT With a prevalence of 10 cases per million, immune thrombotic thrombocytopenic purpura (iTTP) is classified as a rare disease. Yet, it has significant human...
Epilepsy in Alzheimer's disease and related dementias
PROJECT SUMMARY/ABSTRACT Candidate and Goals: Dr. Ifrah Zawar is an Assistant Professor of Neurology at the University of Virginia (UVA) with clinical expertise in neurology and ep...
Using Virtual Reality to help develop discrepancy and elicit change talk in brief motivational interventions for heavy drinking young adults
Project Summary/Abstract Alcohol use is the leading risk factor for premature death among young adults globally. Brief motivational interventions (BMIs) can help young adults reduc...
CARES: A Caregiver-Facing Digital Symptom Assessment Tool for Marginalized Older Adults with Serious Illness
PROJECT SUMMARY This K76 proposal describes the five-year career development plan of Dr. Sarah Nouri, an Assistant Professor in the Division of Palliative Medicine at the Universit...
Developing strategies for using DNA data to assist family reunifications across child development stages
PROJECT SUMMARY Family separations due to disasters, armed conflict, and migration affect millions, are expected to increase, and damage children’s health across the lifecourse. Gi...
Tau-RNA crosstalk: Alternative Poly-Adenylation (APA) Regulation in Alzheimer's Disease
Alzheimer's disease (AD) is a devastating degenerative brain disorder and the most prevalent form of dementia, affecting millions worldwide. Given its significant impact on pu...
Development of Measures to Screen for Financial Hardship in Alzheimer's Disease and Dementia
PROJECT ABSTRACT/SUMMARY Alzheimer's Disease and related dementias (AD/ADRD) are common and debilitating conditions. Financial hardship, a multidimensional construct of financ...
Utilizing senolytics to enhance the response to exercise in cachectic mice
Project Summary. Skeletal muscle mass and function are key determinants of an individual’s healthspan and are tightly correlated with both physical and metabolic health. In cancer...
Cognitive, structural and functional impact of new onset type 1 diabetes on the brain of young children: Understanding risks and protective factors
An increasing body of data show the brain is a target of diabetes complications. We and others have investigated the impact of type 1 diabetes (T1D) in the developing brain in chil...
Defining multifunctional roles for proteins in development and disease
Project Summary This proposal for the NIGMS R35 Early-Stage Investigator award seeks to support my laboratory’s overall mission of determining multifunctional roles for proteins in...
Home-based Digital Technologies: A Translational Approach to Support Aging-in-Place for Rural African-Americans with Alzheimer’s Disease and their Care Partners
PROJECT SUMMARY Candidate and Career Development Plan: This REDI Mentored Entrepreneurial Career Development Award (K01) will support Otis (Shaun) Owens, Ph.D. to establish an inde...
Genetic circuitry governing skin colonization of Candida auris
Abstract Candida auris is an emerging fungal pathogen causing invasive infections worldwide with a high mortality rate. Unlike other fungal pathogens, it is frequently hospital-acq...
Targeted Radionuclide Therapy to Enhance the Efficacy of CAR T Cells Against Neuroblastoma
PROJECT SUMMARY/ABSTRACT Quaovi Sodji, MD, PhD is a Tenure track Assistant Professor in the Department of Human Oncology at the University of Wisconsin School of Medicine and Publi...
Hormone-Free Prebiotic Muco-Adhesive Gels To Treat Vaginal Atrophy in Post-Menopausal Women
PROJECT ABSTRACT/SUMMARY Vaginal Atrophy (VA), a component of Genitourinary Syndrome of Menopause, is a chronic and progressive condition that affects approximately 50% of post-men...
A Triad Approach Towards Improved Diagnostics for Maternal and Congenital Syphilis
Project Summary Syphilis is a sexually and vertically transmitted disease caused by Treponema pallidum subspecies pallidum (TPA). While adult syphilis is often asymptomatic and sel...
Pharmacokinetics and Pharmacodynamics of Mechanistically Aware Phage Cocktails
ABSTRACT: With only one mechanistically novel antibiotic developed in the past decade with activity versus resistant Gram-negatives, extensively-drug resistant Pseudomonas aerugino...
Ketone supplementation as an intervention to alleviate alcohol withdrawal and improve brain energetics in Alcohol Use Disorder
PROJECT SUMMARY/ABSTRACT Alcohol Use Disorder (AUD) is a chronic, relapsing brain disorder that accounts for 5% of deaths globally. There is an urgent need to test interventions th...
Excellence in Research: Building Adaptive Communities via Interdisciplinary Research and Training
Frequent extreme weather events or natural disasters are posing significant threats to lives and livelihoods. Previous research suggests that the historically underserved, minority...
Translational development of new agents alone and in combination to combat Gram-negative pathogens important in Ventilator- Associated Bacterial Pneumonia: Leveraging the Gram-negative toolbox that is
Project Summary/Abstract: Resistance to our major antibiotics has been identified by the CDC as a major threat to the health and safety of the American public. Two of the highest t...