Results for Health
130,725 grants found
Showing 126,401 – 126,420 of 130,725 grants for "Health"
Core 1 Administrative Core
Summary/Abstract Administrative Core #1 Resistance to our major antibiotics has been identified by the CDC as a major threat to the health and safety of the American public. Two of...
Assessment of a recently developed boron-based HIF inhibitor as a prospective therapy for renal cell carcinoma (RCC)
Inactivation of the VHL tumor suppressor protein (pVHL) is frequently observed in clear cell Renal Cell Carcinoma (RCC). The mutated pVHL does not bind and degrade the regulatory α...
Glycemic control and frailty risk in older people at risk for type 2 diabetes: Impact of local heat therapy
Project Summary/Abstract Frailty-related medical expenses cost approximately $18 billion annually in the USA. Progressive losses in skeletal muscle (SKM) mass and function, often o...
Improving Strength Training in Older Adults
PROJECT SUMMARY/ABSTRACT Maintaining muscle mass and strength in older adults is critical for preventing mobility disability, falls, and long-term independence. Although ‘high inte...
A Selective Serotonin Reuptake Inhibitor for Asthma Patients with Frequent Exacerbations
Project Summary/Abstract Asthma prevalence has increased in recent years with 8.4% of adults diagnosed with asthma. Asthma can be a lifelong disease. These rates increase with age,...
Disruption of Endosomal Microautophagy by Pathological Tau Protein
PROJECT SUMMARY/ABSTRACT One of the pathological features of Alzheimer’s disease (AD) is the dysfunction of protein degradation pathways including macro- and chaperone mediated aut...
Investigating the roles of nuclear RNA modifications in gene regulation
RNA modification serves as a major posttranscriptional mechanism to regulate gene expression. Recent advances in high-throughput sequencing have exponentially expanded the breadth...
Discovery and optimization of ApoE4 correctors for the treatment of Alzheimer's Disease
PROJECT SUMMARY Alzheimer's disease (AD) is a major public health crisis with no effective treatments. Apolipoprotein E (ApoE) has three major polymorphic alleles, denoted Apo...
Uncovering the molecular underpinnings of C15, a potent orthopoxvirus virulence factor
PROJECT SUMMARY The orthopoxvirus (OPXV) genus is home to many severe mammalian pathogens, including variola (VARV) and Mpox (MPXV). Though VARV was eradicated in 1980, OPXVs remai...
Defining Mechanisms of SARS-CoV-2 Entry Inhibitors in the Respiratory Epithelium
Project Summary/Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic and severely impacted public health. SARS-CoV-2 primarily infects...
Harnessing Machine Learning & Object Detection for Automated Evaluation of Student-folded Protein Models
Project Summary Harnessing Machine Learning & Object Detection for Automated Evaluation of Student-folded Protein Models This project will impact public health through improved...
Development of an In-Home Sensory Training Therapy to Mitigate Falls Risk Among the Elderly
Falls are a major cause of death and morbidity for older adults in the US each year, and injuries from falls leave many older adults with a greater risk of physical and cognitive d...
Accelerated Rosette Trajectories- Based 5D MR Spectroscopic Imaging AND MR Imaging of Myelin Fraction in Perinatally HIV-Infected Adults
PROJECT SUMMARY Better understanding is needed regarding the mechanism of HIV pathogenesis to the developing brain in individuals receiving longstanding antiretroviral therapy (ART...
Understanding prion-mediated transcriptional modifications and cellular phenotypes: insights into the role of Swi1 prion and prion-like behaviors of BAF proteins
The term "prion" was originally coined to describe the agent responsible for neurodegenerative diseases associated with the prion protein, PrP. This concept has now broad...
Dietary Predictors of New-Onset Diabetes following Acute Pancreatitis in the DREAM Study.
Project Summary/Abstract: This is an application for a K01 award for Djibril M. Ba, PhD, MPH, an assistant professor at the Penn State College of Medicine in the Department of Publ...
Quantification of microstructures in the entorhinal-hippocampus pathway as a sensitive biomarker for neurodegeneration during the preclinical stage of Alzheimer's disease
Project Summary/Abstract Alzheimer's disease (AD) is a global issue that must be solved urgently because of its significant impact on public health and economics, as well as t...
CROSSTALK BETWEEN GUT MICROBIOTA AND HEPATOCELLULAR CARCINOMA INDUCED BY METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE
Metabolic dysfunction-associated steatotic liver disease (MASLD) is considered a world-wide public health problem caused by metabolic syndrome. It is estimated that 30% of the worl...
Modular Toolbox of Protein and Lipid Hybrid Biomaterials for siRNA Delivery
ABSTRACT/PROJECT DESCRIPTION: Technologies for gene delivery are desperately needed to address a wide array of pathological processes in the various tissues of the body. In particu...
Modulation of Ca2+ -activated K+ channels by CFTR Correctors
Cystic fibrosis (CF) results from mutations in the CFTR Cl- channel resulting in diminished transepithelial Cl- secretion. The most common CFTR mutation, F508del, results in a chan...
Intensive Longitudinal Associations between Stress, Mindfulness, and Alcohol Use in Highly Stressed Mothers
Project Summary/Abstract Alcohol use is common in the United States and more frequent use is associated with individual and societal consequences. The use of ecological momentary a...