Results for Health
130,725 grants found
Showing 126,441 – 126,460 of 130,725 grants for "Health"
Non-toxic CNS drug delivery across the BBB in Alzheimer's and other dementias
Project Summary Alzheimer’s disease (AD) is the principal cause of dementia worldwide with its incidence anticipated to double every 20-years as the population ages. It represents...
Development of Novel Small molecule modulators of synaptic plasticity for the treatment of AD-induced cognitive decline
PROJECT SUMMARY Pharmacological treatment to slow or stop the progression or prevent Alzheimer’s Disease (AD) represents an unmet medical need. Clinical evidence shows that the cor...
Technology-based Sleep Self-Management Intervention for Adults with Subarachnoid Hemorrhage
PROJECT SUMMARY/ABSTRACT Subarachnoid hemorrhage (SAH) accounts for 27% of all stroke-related years of potential life lost before 65-years of age. Sleep disturbance (insufficient s...
Pre-clinical testing of a novel gene therapy for pediatric neurodegenerative disease
PROJECT SUMMARY A significant number of pediatric neuromuscular and neurodegenerative conditions are caused by recessive gene mutations resulting in loss of both maternal and pater...
Guanfacine for women with AUD: A multisite study using a telehealth approach
ABSTRACT There is currently a dearth of FDA-approved medications developed specifically for women with alcohol use disorder (AUD). This represents a major public health concern for...
Social Networks for Optimizing Communication Ability in Adult Cochlear Implant Users
Project Summary: One in three adults over the age of 65-years has hearing loss, which has significant negative communicative, cognitive, and social consequences. Although cochlear...
Addressing Food Insecurity in Transplant and Cellular Therapy Patients with Healthcare-Community Partnerships
ABSTRACT Food insecurity (FI), defined as a lack of consistent access to enough food for every person in a household to live an active, healthy life due to insufficient money or ot...
Increasing Access to Hearing Healthcare: An Assessment of Pharmacy Technician Educational Training for the Provision of Over-the-Counter Hearing Aids in Rural Alabama and Mississippi Pharmacies
Project Summary/Abstract Hearing loss is a major public health concern due to its negative association with emotional well-being, cognition, and physical ailments, such as diabetes...
Cardiovascular magnetic resonance assessment of subclinicalcardiovascular abnormalities before and after the initiation of antiretroviral therapy in HIV-infected South Africans
PROJECT SUMMARY Despite modern anti-retroviral treatment (ART), cardiovascular disease (CVD) remains a risk factor for mortality in people living with HIV (PLWH). CVD in PLWH is he...
Advancing the commercialization readiness of nanoparticle-based immunotherapy for cancer treatment
Treatment of non-small cell lung cancer (NSCLC) requires a combination of many highly toxic drugs and radiation therapy, yet the 5-year survival rate remains about 18%. Immune chec...
Digital Interventions to Study and Influence the Alcohol-Atrial Fibrillation Connection
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Alcohol is the most commonly consumed drug in th...
Pragmatic Clinic-Based Trial of a Mindfulness Based Intervention for Mood Concerns in Youth with Type 1 Diabetes
PROJECT SUMMARY / ABSTRACT Type 1 diabetes (T1D) is one of the most common chronic illnesses of childhood. The involved treatment regi- men, including daily insulin administration/...
Development of a Tailored Alcohol Screening, Brief Intervention, and Referral to Treatment Protocol for Older Adults with Chronic Pain
PROJECT SUMMARY/ABSTRACT Hazardous alcohol use is highly prevalent among the millions of older adults who have chronic pain. This is alarming, given that hazardous drinking can exa...
A Motivation-Based Adolescent Vaping Typology to Inform Cessation Interventions
PROJECT SUMMARY/ABSTRACT Since the introduction of e-cigarettes in the U.S. in 2007, there has been a dramatic increase in the prevalence of e-cigarette use among adolescents. Thes...
Project 1: Implementing Risk-based Tools that Incorporate Tumor Biology to Optimize Screening and Prevention
In 2016, we initiated the first large-scale clinical trial to personalize screening based on individual risk, which varies significantly among women. The WISDOM Study is a multi-ce...
A clinical decision support tool to understand the survival benefit of kidney transplantation in candidates with a history of cancer
PROJECT SUMMARY / ABSTRACT: Survival with end-stage kidney disease (ESKD) has improved in the last decade alongside the trend of an aging population with greater risks, including c...
EAGER: Using pupil size as tool for detecting mental imagery
How many windows are in your house or apartment? In answering this question most people visualize their dwelling as they imagine walking around to count the windows. Surprisingly,...
Functional Genomics of Human Brain Development Cluster
Neurodevelopmental conditions like autism, attention deficit hyperactivity disorder (ADHD), epilepsy, and intellectual disability affect millions of children worldwide. These condi...
Phospho- and natural-variant regulation of heterotrimeric G protein signaling
Project Summary/Abstract Numerous cellular signaling pathways of critical importance to organism health rely on heterotrimeric G protein signaling. Heterotrimeric G proteins are co...
Midwest Developmental Center for AIDS Research (D-CFAR)
Project Summary Overall The Midwest D-CFAR seeks to advance impactful HIV research and thereby catalyze greater effectiveness in the HIV response in our region and beyond. More tha...