Results for Health
130,725 grants found
Showing 126,461 – 126,480 of 130,725 grants for "Health"
Cocaine Abstinence or Reduced Use May Retard Alterations in Brain Structure and Function, and Associated Cognitive Changes among African American Cocaine Users with HIV
ABSTRACT Despite the use of effective antiretroviral therapy (ART), HIV-related neurocognitive impairment (NCI) continues to be prevalent among people living with HIV. For more tha...
Neuroinflammatory Status as a Driver of Pathophysiology Following Repetitive Traumatic Brain Injury
Traumatic Brain Injury (TBI) is caused by a mechanical insult to the head and often results in prolonged or permanent brain dysfunction. TBI represents a major health and socioecon...
A Novel ENaC Blocker/Osmolyte Inhalation Solution for the Treatment of Muco-Obstructive Lung Diseases
ABSTRACT Muco-obstructive lung diseases, e.g., COPD, asthma, CF, and PCD, cause major health problems to many citizens of the US. Recent CT data have identified mucus plugging as a...
Supporting WHO Lymphatic Filariasis Elimination Programs: Progressing a Highly Sensitive and Specific Rapid Diagnostic Test for Brugia Species Infection to Commercialization Readiness
PROJECT SUMMARY / ABSTRACT Herein we propose a field-deployable, cost-effective, highly sensitive and specific Rapid Diagnostic Test (RDT) for the surveillance of lymphatic filaria...
Strategies for Personalizing Oxygen and support Therapies for dyspnea in Oncology
PROJECT SUMMARY Dyspnea is one of the most common and distressing symptoms associated with cancer, occurring in nearly 70% of patients with advanced cancer. Dyspnea is associated w...
Collaborative Research: The Role of Tension in the Digestion of Blood Clots
Blood clots form in response to an injury and stop the flow of blood during the wound healing process. The structural scaffold of a blood clot is a mesh of fibers, composed of a bi...
RESEARCH-PGR: Cycling to low-temperature tolerance
Unseasonal cold spells annually cause significant losses in crops, impacting global food security and constraining growing ranges. This project focuses on understanding how sorghum...
Sex Differences in T cell metabolism
Abstract Sex is an important biological variable as it has dramatic impacts on health and disease. Males have a greater risk for infection and severe outcomes, while females have i...
Optimizing an App-based Intervention for Sexual Minoritized Emerging Adults to Reduce Cannabis and Alcohol Co-use
PROJECT SUMMARY/ABSTRACT This K23 award will support Dr. Florimbio, a clinician-scientist with experience researching and treating substance use disorders, in becoming an independe...
Immune regulation of spinal cord regeneration
PROJECT SUMMARY/ABSTRACT Spinal cord injury in mammals triggers a cascade of cellular events that lead to the loss of sensory and motor function caudal to the site of injury. Follo...
Racial Differences in Biomarkers and Therapeutic Targets for Chronic Itch
Itch, or pruritus, is a commonly reported symptom with over 7 million clinician visits annually in the United States. Indeed, the Global Burden of Disease Study by the World Health...
Role of ELOVL2 in age-related visual decline
PROJECT SUMMARY/ABSTRACT Age-related macular degeneration (AMD) is a leading cause of visual disability worldwide, resulting in a significant medical and social burden. While the p...
Deciphering plant stress memory: the exploration of how DNA methylation and the rhizosphere microbiome control stress memory in plants
Plant pests and pathogens pose a major threat to the global food supply.Pesticides are currently the primary control strategy however there is clear evidence that they can negative...
Hyperpolarized MR-PET for evaluating mitochondrial function and availability in an Alzheimers Disease Model
Project Summary/Abstract Metabolic dysfunction is a prominent contributor to the development of Alzheimer’s disease (AD), evidenced by brain glucose hypometabolism observed decades...
Linking Impulsivity Domains and Subjective Response to Alcohol in Young Adults Using Lab and Daily Assessment Methods
PROJECT SUMMARY/ABSTRACT Young adult alcohol misuse is an urgent, growing public health crisis, as young adults have the highest alcohol use disorder rates of any age group with ra...
Optimization of Novel Potassium Channel Kv1.3 Blockers with Potential as Alzheimer's Disease Therapeutics
Abstract (Project Summary) Alzheimer's Disease (AD) is one of the major neurodegenerative disorders and leading cause of dementia, mostly prevalent in the aging population. Ag...
Repurposing of FDA-approved Nrf2 Activators as a Novel Inhaled Therapy for Pulmonary Fibrosis
ABSTRACT: Fibrotic disorders represent a major health problem in the U.S., with a rising incidence (particularly among the elderly). Idiopathic pulmonary fibrosis (IPF) is a relent...
Reducing disparities in chronic pain with a tailored psychosocial education intervention for an underrepresented population
PROJECT SUMMARY/ABSTRACT Health inequalities in chronic pain exists in the US, with a greater burden of chronic pain and higher rate of misdiagnosis and undertreatment reported in...
Dynamics and evolution of a halogenated auxin - a seed-derived signal for pea pod growth
In the history of life on Earth, the evolution of flowering plants (angiosperms) is arguably one of the most impactful events that has shaped the world of today. More than 95% of e...
Two-component signaling systems of Treponema denticola
PROJECT SUMMARY Periodontitis is one of the most common human health conditions and is a chronic inflammatory disease affecting the tooth-supporting structures resulting from the a...