Results for Health
130,725 grants found
Showing 126,501 – 126,520 of 130,725 grants for "Health"
Caregiving, Complex Family and Kinship Ties, and Alzheimer's Disease and Related Dementias (ADRD)
Families and unpaid caregivers provide the majority of assistance to older Americans living with limitations in the U.S. Those living with Alzheimer’s Disease and Related Dementias...
Identification of endophenotypes associated with Alzheimer’s disease progression in Hispanic population
Abstract Dementia is caused by a constellation of age-associated neurodegenerative diseases collectively termed Alzheimer’s disease and related dementias (ADRD). ADRDs impair indiv...
The impact of body composition on peri-operative and patient-centered outcomes in lung transplantation.
PROJECT ABSTRACT Lung transplantation aims to extend survival, relieve disability, and improve health-related quality of life (HRQL). Although many do well, perioperative complicat...
Platelet-mediated mechanisms of placental and systemic hypercoagulability in preeclampsia
PROJECT SUMMARY/ABSTRACT Preeclampsia (PE) remains a significant clinical and public health burden affecting 3-5% of all pregnancies worldwide, and is a leading cause of maternal a...
Development of Broad-Spectrum Cyclic Amphiphilic Peptides against Multidrug-Resistant Bacteria
ABSTRACTThe emergence of antibacterial resistance to common frontline antibiotics, such as methicillin, vancomycin, cephalosporins,and carbapenem, have created a global public heal...
Single arm trial of menstrual cups among economically vulnerable women to reduce Bacterial vaginosis and STIs through reduced harmful sexual and menstrual practices
In western Kenya, HIV prevalence is 16% among women in the general population, and 29% among the most economically constrained women. The HIV/STI epidemic overlaps with broader rep...
DNA ligase activities during base excision repair coordination
PROJECT SUMMARY Base excision repair (BER) is a critical mechanism for preventing the mutagenic and lethal consequences of DNA damage. BER is a multi-step pathway that requires a t...
Effects of NAD restoration on neurovascular coupling in community dwelling older adults
Age-related cognitive decline has emerged as one of the major public health challenges of our time. It is well known that normal cognitive function requires an adequate blood suppl...
Novel targeted therapy for treating Ovarian Cancer
PROJECT SUMMARY: Ovarian cancer (OCa) is the deadliest of all gynecologic cancers in the United States. Patients with OCa initially respond to standard combinations of surgical and...
IntBIO: Collaborative Research: Integrated mechanisms of environment-host-virome interactions
In nature, encounters between humans and wildlife correlate with greater viral burdens in wildlife and therefore with higher risk of new viral pathogens spilling over into human po...
PIPP Phase I: Predicting and Preventing Epidemic to Pandemic Transitions
The COVID-19 pandemic and its effects, both in terms of the millions of lives lost and the trillions in estimated costs, are a recent example of the devastation pandemics can cause...
The Role of Creb5 in Maintaining Synovial Joint Homeostasis
Project Summary/Abstract. The broad, long-term goal of this project is to develop a comprehensive understanding of the regulatory network that regulates the differentiation and mai...
The Role of Creb5 in Maintaining Synovial Joint Homeostasis
Project Summary/Abstract. The broad, long-term goal of this project is to develop a comprehensive understanding of the regulatory network that regulates the differentiation and mai...
Elucidating the mechanisms and consequences of MDSC-regulated immunity in TB
PROJECT SUMMARY: Myeloid derived suppressor cells (MDSCs) are immature myeloid cells with potent inhibitory properties for macrophages and T cells. The link between MDSCs and tuber...
Evaluation of novel tuberculosis LAM assays among people living with HIV and sepsis
PROJECT SUMMARY/ABSTRACT Mycobacterium tuberculosis is a leading cause of sepsis and the leading killer among people living with HIV (PLWH) in sub-Saharan Africa. The diagnosis of...
Implementation of emergency department screening to impact rising syphilis rates in vulnerable populations
PROJECT SUMMARY Syphilis rates in the U.S. have been increasing steadily since 2001, with more than 130,000 new cases reported in 2019. Left untreated, syphilis can lead to neurolo...
Using novel pre-harvest, resistance-conferring treatments to prevent foodborne pathogenic outbreaks in produce
Abstract - Ascribe Bioscience is developing a novel technology to prevent foodborne outbreaks and recalls caused by the consumption of fresh or minimally processed fruits and veget...
Evaluation of novel tuberculosis LAM assays among people living with HIV and sepsis
PROJECT SUMMARY/ABSTRACT Mycobacterium tuberculosis is a leading cause of sepsis and the leading killer among people living with HIV (PLWH) in sub-Saharan Africa. The diagnosis of...
Study of arenavirus assembly
The devastating impact on public health, global economy and social stability incurred by the COVID-19 pandemic in the last two years has highlighted the importance of basic researc...
Studies on bacteriophages in respiratory diseases
PROJECT SUMMARY Dr. Bollyky is a mid-career investigator who has developed a successful, translational research program focused on bacteriophages – viruses that infect bacteria - a...