Results for Health
130,725 grants found
Showing 126,561 – 126,580 of 130,725 grants for "Health"
The Relationship Between Brain Macrophages and Cognitive Dysfunction in Systemic Lupus Erythematosus
Northwestern University PROJECT SUMMARY Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving genetic and environmental factors culminating in multiple detri...
How beta-catenin expands Foxp3+RORgammat+ Pro-inflammatoryT-regulatory cells - Renewal
ABSTRACT The plasticity and functional diversity of regulatory T cells (Tregs) is essential for the maintenance of healthy immunity but it is also exploited in disease. We have des...
The Role of eIF4G1 and eIF4G2 in Translational Control of Adipogenesis and Obesity
PROJECT SUMMARY Obesity, a disease caused by elevated fat mass, has increased in prevalence over the past few decades. Over 30% of the population suffers from obesity, and over tim...
A novel psychological-behavioral intervention to promote physical activity in type 2 diabetes.
Among the 30 million Americans with type 2 diabetes (T2D), physical activity is prospectively associated with better glycemic control, reduced cardiovascular risk, and lower rates...
Continuous ADL monitoring using computer vision to maintain independence and improve HRQoL in older adults at risk for AD/ADRD
To help older adults age independently at home, effectively monitoring and detecting changes in ADLs are critical for preventing adverse events and maintaining health-related quali...
Nonlipogenic ABCA1 inducers for ADRD
Alzheimer's disease and related dementia (ADRD) constitutes a growing health crisis. Equally, chronic metabolic diseases such as type 2 diabetes (T2D) are increasing, because...
Quantifying and Understanding Glaucoma Eye Drop Medication Instillation and Adherence
PROJECT ABSTRACT Despite the availability of effective treatments, glaucoma remains the leading cause of irreversible blindness among African American adults and the second leading...
A Randomized Clinical Trial to Evaluate Solutions for the Management of Virologic Failure for Individuals on TLD in Sub-Saharan Africa
PROJECT SUMMARY Significance: Tenofovir, lamivudine, and dolutegravir (TLD) has become the predominant first-line antiretroviral therapy (ART) regimen in sub-Saharan Africa (SSA)....
Molecular Neurogenetics of the Brainstem Neuronal Source of Cardioprotective Vagal Outflow
We aim to identify, predict and control the central brainstem neurons that integrate interoceptive inputs to produce and determine the activity of the vagus nerve in regulating the...
Cancer Genomics and Genomic Data Science for East Africa
PROJECT SUMMARY/ABSTRACT The 20-years since publication of the draft human genome sequence in 2001 have been a truly transformational era in the field of cancer research marked by...
The role of myosin II in tendon repair under glucose control
Tendon injury and disorders provide a severe negative impact on the economic cost and the ability to meet the patients' occupational, recreational, and health activities. Desp...
StEP OUT
PROJECT SUMMARY/ABSTRACT This Mentored Patient-Oriented Research Career Development Award (K23) proposal will address an urgent need to advance the science of child obesity prevent...
Effect of pericyte stimulation on traumatic brain injury pathophysiology
Brain vascular pericytes are an essential component of the neurovascular unit and perform a number of diverse functions in regulating brain homeostasis. A common feature of many ne...
Examining how the novel S64F MAFA variant produces glucose intolerance or hypoglycemia in a sex-dependent manner
PROJECT ABSTRACT As of 2018, 30.3 million Americans have been diagnosed with diabetes (10% of the U.S. population with a male sex bias). Its close associations with many chronic di...
Uncovering the roles of phages in the ecology of Porphyromonas gingivalis in periodontal disease
PROJECT SUMMARY/ABSTRACT The broad goal of the proposed work is to address the lack of knowledge about the roles of bacterial viruses (phages) in shaping the ecology of oral microb...
Investigation and application of hydrocarbon-degrading enzymes using cryo-electron microscopy and directed evolution
PROJECT SUMMARY Glycyl radical enzymes (GREs) are a growing superfamily that catalyzes an impressive array of chemical transformations critical to both human health and the environ...
A Randomized Clinical Trial to Evaluate Solutions for the Management of Virologic Failure for Individuals on TLD in Sub-Saharan Africa
PROJECT SUMMARY Significance: Tenofovir, lamivudine, and dolutegravir (TLD) has become the predominant first-line antiretroviral therapy (ART) regimen in sub-Saharan Africa (SSA)....
Staphylococcus aureus SPREAD (S. aureus Study of Prevalence Resistance and Environmental Dissemination)
PROJECT SUMMARY Staphylococcus aureus is a bacterial species that causes infections of the skin, lungs, blood and internal organs. These infections can have their onset in the comm...
Investigating the molecular details of assembly, disassembly and trafficking of GPCR-arrestin complexes
Project Summary: Mis-regulation of G protein-coupled receptor (GPCR) trafficking and signaling is implicated in causing several diseases and the development of drug tolerance, havi...
CyberCorps Scholarship for Service (Renewal) - Preparing Scholars for a Career in the Government’s Cybersecurity Workforce
Cybersecurity is increasingly important to society, whether for national defense or for the protection of citizens as they take advantage of today's digital world to maintain...