Results for Health
130,725 grants found
Showing 126,581 – 126,600 of 130,725 grants for "Health"
COVID-19, heavy drinking and alcohol use disorders: a national study of Veterans Administration patients
Coronavirus Disease 2019 (COVID-19) caused by SARS-CoV-2 is a global pandemic. While most COVID-19 cases are mild or moderate, severe cases (~15%) require hospitalization, critical...
Unraveling the Role of PD-1 in CD8+ Tissue-Resident Memory T Cell Homeostasis and Epithelial Damage in Human Colitis
Project Summary Monoclonal antibodies against co-inhibitory immune receptors PD-1 and CTLA-4 [immune checkpoint inhibitors (ICIs)] have revolutionized immuno-oncology by reversing...
A Multicenter Randomized Controlled Trial of a Patient Safety Reporting Intervention for Families to Improve Medical Error Detection and Reduce Inequities
PROJECT SUMMARY/ABSTRACT Hospitals ineffectively examine the safety of their processes by relying on voluntary incident reporting (VIR) by clinical staff who are overworked and afr...
Mechanisms of Risky Alcohol Use in Young Adults: Linking Sleep Duration and Timing to Reward- and Stress-Related Brain Function
7. PROJECT SUMMARY/ABSTRACT The long-term objectives of this proposal are: 1) to evaluate a biobehavioral model of alcohol use disorder (AUD) in young adults with recent high-risk...
A multidisciplinary approach to study ecotypes driving transmission and pathogenesis of Visceral Leishmaniasis (VL) and Post kala-azar dermal leishmaniasis (PKDL) in Eastern Africa
Abstract Over 12 million people currently suffer from leishmaniasis, and ~2 million new cases occur each year, making it a major global health problem and a WHO classified neglecte...
Mechanisms of Risky Alcohol Use in Young Adults: Linking Sleep Duration and Timing to Reward- and Stress-Related Brain Function
7. PROJECT SUMMARY/ABSTRACT The long-term objectives of this proposal are: 1) to evaluate a biobehavioral model of alcohol use disorder (AUD) in young adults with recent high-risk...
Novel therapeutic approaches to improve fracture healing while reducing pain behavior
Veterans with fractures suffer from injury-associated pain as well as post-operative surgical pain. The occurrence of a fracture contributes to acute pain and is largely manifested...
A Multicenter Randomized Controlled Trial of a Patient Safety Reporting Intervention for Families to Improve Medical Error Detection and Reduce Inequities
PROJECT SUMMARY/ABSTRACT Hospitals ineffectively examine the safety of their processes by relying on voluntary incident reporting (VIR) by clinical staff who are overworked and afr...
QBSafe: a randomized trial of a novel intervention to improve care for people living with type 2 diabetes.
PROJECT ABSTRACT: Clinical guidelines, performance measures, and clinical trials for patients with type 2 diabetes mellitus (DM2) have traditionally focused on achieving certain le...
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
Project Summary/Abstract There has been rapid escalation in adolescent-onset type 2 diabetes (T2D), particularly in females from historically disadvantaged racial/ethnic groups. Pr...
Novel non-viral reprogramming strategies to treat Discogenic back pain via engineered extracellular vesicles
Project Summary/Abstract Chronic low back pain is a debilitating disorder of significant socio-economic importance and a major gateway to opioid use. Therefore, minimally invasive...
Novel non-viral reprogramming strategies to treat Discogenic back pain via engineered extracellular vesicles
Project Summary/Abstract Chronic low back pain is a debilitating disorder of significant socio-economic importance and a major gateway to opioid use. Therefore, minimally invasive...
Mechanisms of Risky Alcohol Use in Young Adults: Linking Sleep Duration and Timing to Reward- and Stress-Related Brain Function
7. PROJECT SUMMARY/ABSTRACT The long-term objectives of this proposal are: 1) to evaluate a biobehavioral model of alcohol use disorder (AUD) in young adults with recent high-risk...
COVID-19, heavy drinking and alcohol use disorders: a national study of Veterans Administration patients
Coronavirus Disease 2019 (COVID-19) caused by SARS-CoV-2 is a global pandemic. While most COVID-19 cases are mild or moderate, severe cases (~15%) require hospitalization, critical...
Understanding Harmful Alcohol Use in Context: Utility of Dynamic Assessment of Behavioral Economic Risk Factors
PROJECT SUMMARY Excessive alcohol use and alcohol use disorder (AUD) remain prevalent in the United States, with the mortality rate associated with alcohol use increasing. Despite...
Planar Cell Polarity Control in Melanoma Metastasis
Melanoma is a highly aggressive cancer that begins in melanin-producing melanocytes in the skin. It accounts for only about 1% of skin cancers, but it is the leading cause of skin...
Immunoregulation of cellular immunity and tissue homeostasis during Chagas' disease
PROJECT SUMMARY/ABSTRACT Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America but cases are increasing in non-endemic countries, becoming a global...
A stem cell activated cryogel bioscaffold that restores islet bioenergetics while providing oxygen and nutrients at extravascular sites of transplantation
PROJECT SUMMARY Islet transplantation is a β-cell replacement therapy used to treat diabetic patients who lack the ability to secreteinsulin. The conventional site for islet transp...
Spatiotemporal control of ubiquitination by phosphoinositide-binding proteins
Project Summary/Abstract Progression through the cell cycle involves spatiotemporal coordination of cytoskeletal and membrane dynamics with controlled proteolysis events. The anaph...
Establishing Mechanisms Between Traumatic Brain Injury and Dementia Using Epidemiology, Clinical Studies, Blood-Based Biomarkers, and Neuroimaging Biomarkers
PROJECT SUMMARY / ABSTRACT Traumatic brain injury (TBI) is common and is associated with significant morbidity and mortality. The sequelae from TBI can be long-lasting, and multipl...